Tal Pupko - Publications:

62. Gelfman, S., Burstein, D., Penn, O., Schwartz, S., Pupko, T., and Ast, G. 2012. Changes in exon-intron structure during vertebrate evolution affect the splicing pattern of exons. Genome Res. 22(1):35-50. [pdf] [abs]

61. Privman, E, Penn, O. and Pupko, T. 2012. Improving the performance of positive selection inference by filtering unreliable alignment regions. Mol. Biol. Evol. 29(1):1-5. [pdf] [abs]

60. Burstein, D., Gould, S.B., Zimorski, V., Klosges, T., Kiosse, F., Major, P., Martin, W., Pupko, T., Dagan, T. 2012. A machine-learning approach to identify hydrogenosomal proteins in Trichomonas vaginalis. Eukaryotic Cell 11:217-228 [pdf] [abs]


59. Turner, D., Amit, S., Chalom, S., Penn, O., Pupko T., Katchman, E., Matus, N., Tellio, H., Katzir, M., Avidor, B. 2012. Emergence of an HIV-1 cluster harboring the major protease L90M mutation among treatment-naive patients in Tel-Aviv, Israel. HIV Medicine. accepted .

58. Cohen, O. and Pupko, T. 2011. Inference of gain and loss events from phyletic patterns using stochastic mapping and maximum parsimony – a simulation study. Genome Biol Evol 3 1265-1275. [pdf] [abs]


57. Rubinstein, N.D., Zeevi, D., Oren, Y., Segal, G., and Pupko, T. 2011. The operonic location of auto-transcriptional repressors is highly conserved in bacteria. Mol. Biol. Evol. 28(12):3309-3318. [pdf] [abs]

56. Rubinstein, N.D., Mayrose, I., Doron-Faigenboim, A., and Pupko, T. 2011. Evolutionary models accounting for layers of selection in protein coding genes and their impact on the inference of positive selection . Mol. Biol. Evol. 28(12):3297-3308. [pdf] [abs]

55. Barzel, A., Privman, E., Peeri, M., Naor, A., Shachar, E., Burstein, D., Lazary, R., Gophna, U., Pupko, T., and Kupiec, M. 2011. Native homing endonucleases can target conserved genes in humans and in animal models. Nucleic Acids Research. 39(15):6646-6659. [pdf] [abs]

54. Cohen, O., and Pupko, T. 2011. The complexity hypothesis revisited: connectivity rather than function constitutes a barrier to horizontal gene transfer. Mol. Biol. Evol. 28(4):1481-1489. [pdf] [abs]

53. Pupko, T. 2011. Evolution after gene dupliction. Book review. Trends in Evolutionary Biology 3:e1. [pdf]

52. Keren, H., Donyo, M., Zeevi, D., Maayan, C., Pupko, T., and Ast, G. 2010. Phosphatidylserine increases IKBKAP levels in familial dysautonomia cells. PLoS ONE 5(12):e15884. [pdf] [abs]

51. Cohen, O., Ashkenazy, H., Belinky, F., Huchon, D., and Pupko, T. 2010. GLOOME: gain loss mapping engine. Bioinformatics 26(22):2914–2915. [pdf] [abs]

50. Penn, O., Privman, E., Ashkenazy, H., Landan, G., Graur, D., and Pupko, T. 2010. GUIDANCE: a web server for assessing alignment confidence scores. Nucleic Acids Research. 38(Web Server issue):W23-W28. [pdf] [abs]

49. Ashkenazy, H., Erez, E.,Martz, E., Pupko, T., and Ben-Tal, N. 2010. ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids. Nucleic Acids Research. 38(Web Server issue):W529-W533. [pdf] [abs]

48. Loe-Mie1, Y., Lepagnol-Bestel, A.D., Maussion, G., Doron-Faigenboim, A., Imbeaud, S., Delacroix, H., Aggerbeck, L., Pupko, T., Gorwood, P., Simonneau, M., and Moalic, J.M. 2010. SMARCA2 and other genome-wide supported schizophrenia-associated genes: regulation by REST/NRSF, network organization and primate-specific evolution. Human Molecular Genetics 19(14):2841-2857. [pdf] [abs]

47. Penn, O., Privman, E., Landan, G., Graur, D., and Pupko, T. 2010. An alignment confidence score capturing robustness to guide-tree uncertainty. Mol. Biol. Evol. 27(8):1759-1767. [pdf] [abs]

46. Cohen, O., and Pupko T. 2010. Inference and characterization of horizontally transferred gene families using stochastic mapping. Mol. Biol. Evol. 27(3):703-713. [pdf] [abs]

45. Stern, A., Mayrose, I., Penn, O., Shaul, S., Gophna, U., and Pupko, T. 2010. An evolutionary analysis of lateral gene transfer in thymidylate synthase enzymes. Systematic Biology. 59(2):212-225. [pdf] [abs]

44. Rubinstein, N.D., Mayrose I, Martz E, and Pupko T. 2009. Epitopia: a web-server for predicting B-cell epitopes. BMC Bioinformatics. 10:287. [pdf] [abs]

43. Burstein, D., Zusman, T., Degtyar, E., Viner, R., Segal, G., and Pupko, T. 2009. Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog 5(7):e1000508. [pdf] [abs]

42. Blanga-Kanfi, S., Miranda, H., Penn, O., Pupko, T., DeBry, R.W., and Huchon, D. 2009. Rodent phylogeny revised: Analysis of six nuclear genes from all major rodent clades. BMC Evolutionary Biology 9:71 [pdf] [abs]

41. Rubinstein, N.D., Mayrose, I., and Pupko, T. 2009. A machine-learning approach for predicting B-cell epitopes. Mol. Immunol. 46(5):840-847. [pdf] [abs]

40. Penn, O., Stern, A., Rubinstein, N.D., Dutheil, J., Bacharach, E., Galtier, N., and Pupko, T. 2008. Evolutionary modeling of rate shifts reveals specificity determinants in HIV-1 subtypes. PLoS Comput Biol. 4(11):e1000214. [pdf] [abs]

39. Sela, N., Stern, A., Makalowski, W., Pupko. T., and Ast, G. 2008. Transduplication resulted in the incorporation of two protein-coding sequences into the Turmoil-1 transposable element of C. elegans. Biology Direct. 3:41. [pdf] [abs]

38. Cohen, O., Rubinstein, N.D., Stern, A., Gophna, U., and Pupko, T. 2008. A likelihood framework to analyse phyletic patterns. Philos Trans R Soc Lond B Biol Sci. 363:3903-3911. [pdf] [abs]

37. Rubinstein, N.D., Mayrose, I., Halperin, D., Yekutieli, D., Gershoni, J.M., and Pupko, T. 2008. Computational characterization of B-cell epitopes. Mol. Immunol. 45:3477-3489. [pdf] [abs]

36. Schwartz, S., Silva, J., Burstein, D., Pupko, T., Eyras, E., and Ast, G. 2008. Large scale comparative analysis of splicing signals and their corresponding splicing factors in eukaryotes. Genome Res. 18(1):88-103. [pdf] [abs]

35. Mayrose, I., Penn, O., Erez, E., Rubinstein, N.D., Shlomi, T., Tarnovitski Freund, N., Bublil, E., Rupin, E., Sharan, R., Gershoni, J.M., Martz, E., and Pupko, T. 2007. Pepitope: epitope mapping from affinity-selected peptides. Bioinformatics 23(23):3244-3246. [pdf] [abs]

34. Lev-Maor, G., Goren, A., Sela, A., Kim, E., Keren, H., Doron-Faigenboim, A., Leibman-Barak, S., Pupko, T., and Ast, G. 2007. The "alternative" choice of constitutive exons through evolution. PLoS Genet. 3(11):e203. [pdf] [abs]

33. Mayrose, I., Doron-Faigenboim, A., Bacharach, E., and Pupko, T. 2007. Towards realistic codon models: among site variability and dependency of synonymous and nonsynonymous rates. Bioinformatics. 23:i319-i327. [pdf] [abs]

32. Stern, A., Doron-Faigenboim, A., Bacharach, E., and Pupko, T. 2007. Selecton 2007: advanced models for detecting positive and purifying selection using a Bayesian inference approach. Nucleic Acids Research. 35:W506-W511. [pdf] [abs]

31. Bublil, E.M., Freund, N.T., Mayrose, I., Penn, O., Roitburd-Berman, A., Rubinstein, N.D., Pupko, T., and Gershoni, J.M. 2007. Stepwise prediction of conformational discontinuous B-cell epitopes using the Mapitope algorithm. Proteins 68(1):293-304. [pdf] [abs]

30. Doron-Faigenboim, A., and Pupko, T. 2007. A combined empirical and mechanistic codon model. Mol. Biol. Evol. 24(2):388-397. [pdf] [abs]

29. Mayrose, I., Shlomi, T., Rubinstein, N., Gershoni, J.M., Ruppin, E., Sharan, R., and Pupko, T. 2007. Epitope mapping using combinatorial phage-display libraries: A graph-based algorithm. Nucleic Acids Research. 35(1):69-78. [pdf] [abs]

28. Ninio, M., Privman, E., Pupko, T., and Friedman, N. 2007. Phylogeny reconstruction: increasing the accuracy of pairwise distance estimation using Bayesian inference of evolutionary rates. Bioinformatics. 23:e136-e141. [pdf] [abs]

27. Stern, A., Privman, E., Rasis, M., Lavi, S., and Pupko, T. 2007. Evolution of the metazoan protein phosphatase 2C superfamily. J. Mol. Evol. 64(1):61-70. [pdf] [abs]

26. Goren, A., Ram, O., Amit, M., Keren, H., Lev-Maor, G., Vig, I., Pupko, T., and Ast, G. 2006. Comparative analysis identifies exonic splicing regulatory sequences - the complex definition of enhancers and silencers. Mol. Cell 22(6):769-781. [pdf] [abs]

25. Shaul, S., Nussinov, R., and Pupko, T. 2006. Paths of lateral gene transfer of lysyl-aminoacyl-tRNA synthetases with a unique evolutionary transition stage of prokaryotes coding for class I and II varieties by the same organisms. BMC Evol. Biol. 6:12. [pdf] [abs]

24. Stern, A., and Pupko, T. 2006. An evolutionary space-time model with varying among-site dependencies. Mol. Biol. Evol. 23(2):392-400. [pdf] [abs]

23. Mayrose, I., Friedman, N., and Pupko, T. 2005. A Gamma mixture model better accounts for among site rate heterogeneity. Bioinformatics. 21:Suppl 2:ii151-ii158. [pdf] [abs]

22. Nimrod, G., Glaser, F., Steinberg, D., Ben-Tal, N., and Pupko, T. 2005. In silico identification of functional regions in proteins. Bioinformatics. 21 Suppl 1:i328-i337. [pdf] [abs]

21. Landau, M., Mayrose, I., Rosenberg, Y., Glaser, F., Martz, E., Pupko, T., and Ben-Tal, N. 2005. ConSurf 2005: The projection of evolutionary conservation scores of residues on protein structures. Nucleic Acid Research. 33:W299-W302. [pdf] [abs]

20. Dutheil, J., Pupko, T., Jean-Marie, A., and Galtier, N. 2005. A model-based approach for detecting co-evolving positions in a molecule. Mol. Biol. Evol. 22(9):1919-1928. [pdf] [abs]

19. Mayrose, I., Mitchell, A., and Pupko, T. 2005. Site-specific evolutionary rate inference: taking phylogenetic uncertainty into account. J. Mol. Evol. 60(3):345-353. [pdf] [abs]

18. Doron-Faigenboim, A., Stern, A., Mayrose, I., Bacharach, E., and Pupko, T. 2005. Selecton: a server for detecting evolutionary forces at a single amino-acid site. Bioinformatics. 21(9):2101-2103. [pdf] [abs]

17. Glaser, F., Rosenberg, Y., Kessel, A., Pupko, T., and Ben-Tal, N. 2005. The ConSurf-HSSP database: the mapping of evolutionary conservation among homologs onto PDB Structures. Proteins. 58(3):610-617. [pdf] [abs]

16. Mayrose, I., Graur, D., Ben-Tal, N., and Pupko, T. 2004. Comparison of site-specific rate-inference methods: Bayesian methods are superior. Mol. Biol. Evol. 21(9):1781-1791. [pdf] [abs]

15. Melamed, D., Mark-Danieli, M., Kenan-Eichler, M., Kraus, O., Castiel, A., Laham, N., Pupko, T., Glaser, F., Ben-Tal, N., and Bacharach, E. 2004. The conserved carboxy-terminus of the human immunodeficiency virus type 1 Gag protein is important for virion assembly and release. J Virol. 78(18): 9675-9688. [pdf] [abs]

14. Berezin, C., Glaser, F., Rosenberg, J., Paz, I., Pupko, T., Fariselli, P., Casadio, R., and Ben-Tal, N. 2004. ConSeq: The identification of functionally and structurally important residues in protein sequences. Bioinformatics 20(8):1322-1324. [pdf] [abs]

13. Pe'er, I., Pupko, T., Shamir, R., and Sharan, R. 2004. Incomplete directed perfect phylogeny. SIAM J. on Computing. 33(3):590-607. [pdf] [abs]

12. Pupko, T., Sharan, R., Hasegawa, M., Shamir, R., and Graur, D. 2003. Detecting excess radical replacements in phylogenetic trees. Gene. 13(319):127-135. [pdf] [abs]

11. Glaser, F., Pupko, T., Paz, I., Bechor, D., Martz, E., and Ben-Tal, N. 2003. ConSurf: A server for the identification of functional regions in proteins by surface-mapping of phylogenetic information. Bioinformatics 19(1):163-164. [pdf] [abs]

10. Pupko, T., Huchon, D., Cao, Y., Okada, N., and Hasegawa, M. 2002. Combining multiple datasets in a likelihood analysis: which models are best. Mol. Biol. Evol. 19(12):2294-2307. [pdf] [abs]

9. Pupko, T., Bell, R.E., Mayrose, I., Glaser, F., and Ben-Tal, N. 2002. Rate4Site: an algorithmic tool for the identification of functional regions on proteins by surface mapping of evolutionary determinants within their homologues. Bioinformatics 18 Suppl:S71-S77. [pdf] [abs]

8. Pupko, T., and Galtier, N. 2002. A covarion-based method for detecting molecular adaptation: application to the evolution of primate mitochondrial genomes. Proc R Soc Lond B Biol Sci. 269(1498):1313-1316. [pdf] [abs]

7. Pupko, T., Pe'er, I., Graur, D., Hasegawa, M., and Friedman,s N. 2002. A branch-and-bound algorithm for the inference of ancestral amino-acid sequences when the replacement rate varies among sites: application to the evolution of five gene families. Bioinformatics 18(8):1116-1123. [pdf] [abs]

6. Friedman, N., Ninio, M., Pe'er, I., and Pupko, T. 2002. A structural EM algorithm for phylogenetic inference. J. Comput. Biol. 9(2):331-353. [pdf] [abs]

5. Pupko, T., and Graur, D. 2002. Fast computation of maximum likelihood trees by numerical approximation of amino-acid replacement probabilities. Computational Statistics and Data Analysis 40:285-291. [pdf] [abs]

4. Pupko, T., Sharan, R., Hasegawa, M., Shamir, R., and Graur, D. 2001. A chemical-distance-based test for positive Darwinian selection. Lecture Notes in Computer Science 2149:142-155.

3. Graur, D., and Pupko, T. 2001. The Permian bacterium that isn't. Mol. Biol. Evol. 18(6):1143-1146. [pdf]

2. Pupko, T., Pe'er, I., Shamir, R., and Graur, D. 2000. A fast algorithm for joint reconstruction of ancestral amino-acid sequences. Mol. Biol. Evol. 17(6):890-896. [pdf] [abs]

1. Pupko, T., and Graur, D. 1999. Evolution of microsatellites in the yeast Saccharomyces cerevisiaei: role of length and number of repeated units. J. Mol. Evol. 48:313-316. [pdf] [abs]

Book chapter:

1. Pupko, T., Doron-Faigenboim, A., Liberles, DA., and Cannarozzi, GM. 2007. Probabilistic models and their impact on the accuracy of reconstructed ancestral protein sequences. In Liberles DA (Editor). Ancestral sequence reconstruction. Oxford University Press.

2. Pupko, T., and Mayrose, I. 2010. Probabilistic methods and rate heterogeneity. In Lodhi., H., and Muggleton, S (Editors). Element of computational systems biology. Wiley Book Series on Bioinformatics.

Refereed Proceedings:

1. Pupko, T., Sharan, R., Hasegawa, M., Shamir, R., and Graur, D. 2001. A chemical-distance-based test for positive Darwinian selection. Proceeding of the 1st Workshop on Algorithms in BioInformatics BRICS, University of Aarhus, Denmark, August 28-31, 2001.

2. Friedman, N., Ninio, M., Pe'er, I., and Pupko, T. 2001. A Structural EM Algorithm for Phylogenetic Inference. Proceedings of the Fifth Annual International Conference on Computational Biology. Ed. Lengauer, T., Sankoff, D., Istrail, S., Pevzner, P., and Waterman, M. pp. 132-140. [pdf]

Abstracts:

1. Pupko, T., Sharan. R., Shamir, R., and Graur. D. 2001. A Test for Positive Darwinian Selection. Currents in Computational Molecular Biology. Ed. El-Mabrouk N., Lengauer, T., and Sankoff, D. pp. 213-214. Les Publications CRM, Montreal, Canada. [pdf]

2. Friedman, N., Pe'er, I., and Pupko, T. 2001. Branch-and-Bound Reconstruction of Ancestral Sequences. Currents in Computational Molecular Biology. Ed. El-Mabrouk N., Lengauer, T., and Sankoff, D. pp. 201-202. Les Publications CRM, Montreal, Canada. [pdf]

3. Pupko, T. and Pe'er I. 2000. Maximum likelihood reconstruction of ancestral amino-acid sequences. Currents in Computational Molecular Biology. Ed. Miyano, S., Shamir, R, and Takagi, T. pp. 184-185. Universal Academy Press, Tokyo, Japan. [pdf]