פרופ' יהונתן חייטין רובינשטיין

סגל אקדמי בכיר בפיזיולוגיה ופרמקולוגיה
פיזיולוגיה ופרמקולוגיה סגל אקדמי בכיר
ניווט מהיר:
פרופ' יהונתן חייטין רובינשטיין
טלפון פנימי: 03-6409261
טלפון נוסף: 03-6409894
פקס: 03-6409894
!Welcome to the Haitin lab
משרד: רפואה-סאקלר, 532

מידע כללי

Deciphering the Molecular Mechanisms of Ion Channels and Prenyltransferases Modulation

Ion channels are intricate membrane-embedded molecular machines, which enable cells to communicate with their surroundings by allowing and maintaining crucial ionic flow across the plasma membrane. Diverse activation and regulatory mechanisms render these specialized proteins perfectly engineered for communicating a wide array of incoming signals into precisely orchestrated electrical-cellular responses.

At the Haitin lab, part of the Sackler School of Medicine, we focus on understanding how ion channels structures are funneled into their specialized activities. Specifically, we are interested in the emerging roles of ion channels in shaping the immune response, and in their contribution to facilitated cellular proliferation observed in cancerous transformation. To do so, we use a wide array of cutting-edge approaches, which include structural biology techniques, electrophysiology, fluorescence spectroscopy and high-throughput cancer-related mutant functional screens.

As ion channels are of immense importance for human health, with emerging pivotal roles in cancer biology, our comprehensive efforts to unveil utmost basic mechanisms underlying ion channels activity should provide novel insights into their regulation and may prove beneficial for future development of novel therapeutic strategies.

Funding:

  • 2018-2019       Shtacher Award for Biomedical Research in Pharmacology
  • 2017-2018       Instruct R&D Award
  • 2016-2019       Israel Cancer Research Fund (ICRF), Research Career Development Award
  • 2016-2020       Israel Science Foundation, Personal Grant
  • 2016-2017       German-Israeli Foundation for Scientific Research and Development (GIF), Young Scientists Program Grant
  • 2016-2018       Recanati Foundation for Biomedical Research Grant
  • 2015-2020       Member, The I-CORE on Integrated Structural Cell Biology

Publications

Selected publications

  1. Manori B.#, Vaknin A.#, Vaňková P., Nitzan A., Zaidel-Bar R., Man P., Giladi M.* & Haitin Y.* (2024) Chloride intracellular channel (CLIC) proteins function as fusogens. Nat commun, 15, 2085.
  2. Giladi M., Lisnyansky Bar-El M., Vankova P., Ferofontov A., Melvin E., Alkaderi S., Kavan D., Redko B., Haimov E., Wiener R., Man P. & Haitin Y. (2022) Structural basis for long-chain isoprenoids synthesis by cis-prenyltransferases. Sci Adv, 8, eabn1171.
  3. Lisnyansky Bar-El M., Vankova P., Yeheskel A., Engel H., Man P., Haitin Y.* & Giladi M.* (2020) Structural basis of heterotetrameric assembly and disease mutations in the human cis-prenyltransferase complex. Nat Commun. 11, 5273.
  4. Ferofontov A., Vankova P., Man P., Giladi M. & Haitin Y. (2020) Conserved cysteine dioxidation enhances membrane interaction of human Cl- intracellular channel 5. FASEB J. 34, 9925-9940.
  5. Ferofontov A., Strulovich R., Marom M., Giladi M. & Haitin Y. (2018). Inherent flexibly of CLIC6 revealed by crystallographic and solution studies. Sci Rep. 8, 6882.
  6. Haitin Y., Carlson A.E., Zagotta W.N. (2013). Structural mechanism for regulation of KCNH channels by the eag domain. Nature, 501:444-448.

A full list of publications can be reached via ORCID 0000-0002-1648-6792 or https://www.ncbi.nlm.nih.gov/myncbi/yoni.haitin.1/bibliography/public/.

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