ד"ר מיכל הלפרין שטרנפלד

Dr. Michal Halperin-Sternfeld, D.M.D., M.Sc., Ph.D., Specialist in Periodontology

Gray Faculty of Medical & Health Sciences, The Goldschleger School of Dental Medicine, Tel Aviv University.

Senior Lecturer in Periodontology & Dental Implantology, the Department of Periodontology & Dental Implantology and the Department of Oral Biology

Head of The Laboratory of Bone Immunomodulation in Health & Disease, the Department of Oral Biology & The Jan Koum Center for Nanoscience and Nanotechnology

Post Graduate Program Director, the Department of Periodontology & Dental Implantology

• Completed her D.M.D studies at Tel Aviv University in 2009.

• A specialist in Periodontology & Dental Implants since 2016 after completing her residency in the Department of Periodontology & Implant Dentistry at Rambam Health Care Campus, Haifa, Israel.

• Holds both a Master’s degree (M.Sc.) and a Doctoral degree (Ph.D.) in Medical Sciences.
  Ph.D Research title: Peptide-Based Hydrogel Scaffolds for Bone Regeneration                                                  

• Completed fellowships and visiting scholar positions at Harvard, Columbia, the University of Michigan, and Northwestern University.

• Post graduate program director and Senior Lecturer at the Department of Periodontology & Dental Implantology, The Goldschleger School of Dental Medicine, Gray Faculty of Medical & Health Sciences, Tel Aviv University.

• ​Head of The Laboratory of Bone immunomodulation in Health & Disease, The Department of Oral Biology, The Goldschleger School of Dental Medicine, Gray Faculty of Medical & Health Sciences, Tel Aviv University.

• A member of The International Association for Dental Research (IADR), The Israeli Society of Periodontology and Osseointegration, The European Federation of Periodontology (EFP) and a frequent speaker at international dental and biomaterials conferences.

1. Immunomodulatory Fibrous Hyaluronic Acid–Fmoc–Diphenylalanine Hydrogel Induces Bone Regeneration
   M Halperin-Sternfeld, A Pokhojaev, M Ghosh, D Rachmiel, R Kannan, ..., Journal of Clinical Periodontology 50(2), 200–219 (2023)

2. Improving the Mechanical Rigidity of Hyaluronic Acid by Integration of a Supramolecular Peptide Matrix
   M Aviv, M Halperin-Sternfeld, I Grigoriants, L Buzhansky, ..., ACS Applied Materials & Interfaces 10(49), 41883–41891 (2018)

3. Molecular and Histological Characterization of a Novel Hydrogel-Based Strategy for Inducing Experimental Glaucoma in Mice.Obied, B., Richard, S., Kramarz Dadon, J., Sela, T. C., Geffen, N., Halperin-Sternfeld, M., Adler-Abramovich, L., Goldenberg-Cohen, N., & Zahavi, A. International journal of molecular sciences, 26(20), 9860. (2025)

4. 3D-Printed Titanium Implants with Bioactive Peptide–Polysaccharide Scaffolds for Personalized Bone Reconstruction
   N Rattner, V Perlis, E Golden, A Pokhojaev, R Sarig, I Binderman, M Halperin-Sternfeld, ... bioRxiv, 2025

5. The Immunobiological and Dense Collagen Fibrous Connective Tissue Barriers: The Gate to Periodontal and Peri-Implant Health and Longevity, I Binderman, M Halperin-Sternfeld, A Miselli, IntechOpen, 2025.

6. In Vitro Evaluation of a Semi-Autologous Fibrin Sealant for Surgical Applications
   U Elbaz, O Berliner, S Tabo, S Yeshayahu, R Kesner, D Cohen-Gerassi, M Halperin-Sternfeld, ..., Macromolecular Bioscience 25(4), 2400165 (2025)

7. Enzyme-Responsive Nanoparticles for Dexamethasone Targeted Delivery to Treat Inflammation in Diabetes
   N Schiffmann, Y Liang, CE Nemcovsky, M Almogy, M Halperin-Sternfeld, ...,Advanced Healthcare Materials 12(28), 2301053 (2023)

8. Thixotropic Red Microalgae Sulfated Polysaccharide–Peptide Composite Hydrogels as Scaffolds for Tissue Engineering
   M Halperin-Sternfeld, GN Liberman, R Kannan, F Netti, PX Ma, ..., Biomedicines 10(6), 1388 (2023)

9. Stabilizing Gelatin-Based Bioinks Under Physiological Conditions by Incorporation of Ethylene-Glycol-Conjugated Fmoc-FF Peptides
   F Netti, M Aviv, Y Dan, S Rudnick-Glick, M Halperin-Sternfeld, ..., Nanoscale 14(23), 8525–8533 (2022)

10. Hyaluronic Acid and a Short Peptide Improve the Performance of a PCL Electrospun Fibrous Scaffold for Bone Tissue Engineering Applications
    D Rachmiel, I Anconina, S Rudnick-Glick, M Halperin-Sternfeld, ..., International Journal of Molecular Sciences 22(5), 2425 (2021)

11. Sonochemical Functionalization of Cotton and Non-Woven Fabrics with Bio-Inspired Self-Assembled Nanostructures
    L Khadeja, I Grigoriants, M Halperin-Sternfeld, A Yona, ... Israel Journal of Chemistry 60(12), 1190–1196 (2020)

12. Surface Modification by Nano-Structures Reduces Viable Bacterial Biofilm in Aerobic and Anaerobic Environments
    S Ya’ari, M Halperin-Sternfeld, B Rosin, L Adler-Abramovich, International Journal of Molecular Sciences 21(19), 7370 (2020)

13. Structural Transformation and Morphology of Dipeptide Supramolecular Assemblies by Liquid-Phase TEM
    K Gnanasekaran, M Halperin-Sternfeld, D Cohen, O Berger, ..., Microscopy and Microanalysis 26(S2), 1442–1443 (2020)

14. Biomaterials Selection – Cellular Interactions During Regenerative and Remodeling Phases
    I Binderman, M Halperin-Sternfeld, E Netanely, S Pohl, RA Horowitz, ..., In: Bone Augmentation by Anatomical Region, 43–60 (2020)

15. Biological Communications Between Implants and Periodontal Tissues
    I Binderman, M Halperin-Sternfeld, Current Oral Health Reports 6(4), 264–268 (2020)

16. Bio-Mimicking of Extracellular Matrix
    M Ghosh, M Halperin-Sternfeld, L Adler-Abramovich, In: Biological and Bio-Inspired Nanomaterials (2019)

17. Injectable Alginate–Peptide Composite Hydrogel as a Scaffold for Bone Tissue Regeneration
    M Ghosh, M Halperin-Sternfeld, I Grinberg, L Adler-Abramovich, Nanomaterials 9(4), 497 (2019)

18. UV Light–Responsive Peptide-Based Supramolecular Hydrogel for Controlled Drug Delivery
    ME Roth-Konforti, M Comune, M Halperin-Sternfeld, I Grigoriants, ... Macromolecular Rapid Communications 39(24), 1800588 (2019)

19. Lateral Guided Bone Regeneration Using a Novel Synthetic Bioresorbable Membrane: A Prospective Randomized Controlled Trial
    M Halperin-Sternfeld, H Zigdon-Giladi, L Shapira, A Wilensky, Journal of Molecular and Clinical Medicine 1(3), 169–176 (2018)

20. Dimensional Changes of the Alveolar Ridge in the Posterior Maxilla and Sinus Pneumatization Following Tooth Extraction
    I Levi, M Halperin-Sternfeld, H Zigdon-Giladi, EE Machtei, J Horwitz, Journal of Molecular and Clinical Medicine 1(2), 93–98 (2018)

21. Arginine-Presenting Peptide Hydrogels Decorated With Hydroxyapatite as Biomimetic Scaffolds for Bone Regeneration
    M Ghosh, M Halperin-Sternfeld, I Grigoriants, J Lee, KT Nam, ..., Biomacromolecules 18(11), 3541–3550 (2018)

22. Advantages of Self-Assembled Supramolecular Polymers Toward Biological Applications
    M Halperin-Sternfeld, M Ghosh, L Adler-Abramovich, In: Supramolecular Chemistry of Biomimetic Systems, 9–35 (2017)

23. Dimensional Changes of the Maxillary Sinus Following Tooth Extraction with and without Socket Preservation
    I Levi, M Halperin-Sternfeld, J Horwitz, H Zigdon-Giladi, EE Machtei, Clinical Implant Dentistry and Related Research 19(5), 952–958 (2017)

24. Molecular Co-Assembly as a Strategy for Synergistic Improvement of the Mechanical Properties of Hydrogels
    M Halperin-Sternfeld, M Ghosh, R Sevostianov, I Grigoriants, ...Chemical Communications 53(69), 9586–9589 (2017)

25. The Pathogenesis of Implant-Related Reactive Lesions: A Clinical, Histologic, and Polarized Light Microscopy Study
    M Halperin-Sternfeld, E Sabo, S Akrish, Journal of Periodontology 87(5), 502–510 (2017)

26. The Association Between Dental Proximal Restorations and Periodontal Disease: A Retrospective 10–18 Years Longitudinal Study
    M Halperin-Sternfeld, M Saminsky, EE Machtei, J Horwitz, Quintessence International 47(3) (2016)

27. The Association Between Shallow Vestibular Depth and Peri-Implant Parameters: A Retrospective 6 Years Longitudinal Study
    M Halperin-Sternfeld, H Zigdon-Giladi, EE Machtei, Journal of Clinical Periodontology 43(3), 305–310 (2016)

28. Patient Movement During Extraoral Radiographic Scanning
    M Halperin-Sternfeld, EE Machtei, C Balkow, J Horwitz, Oral Radiology 32(1), 40–47 (2016)

29. Survival Rate of Teeth in a Periodontal Office – Up to 18 Years Follow-Up
    M Saminsky, M Halperin-Sternfeld, E Machtei, J Horwitz, Journal of Clinical Periodontology 42 (2016)

30. The Association Between Proximal Restorations and Periodontal Status: A Retrospective 10-Year Longitudinal Study
    M Halperin-Sternfeld, M Saminsky, E Machtei, J Horwitz, Journal of Clinical Periodontology 42 (2015)

31. Variables Affecting Tooth Survival and Changes in Probing Depth: A Long-Term Follow-Up of Periodontitis Patients
    M Saminsky, M Halperin-Sternfeld, EE Machtei, J Horwitz, Journal of Clinical Periodontology 42(6), 513–519 (2015)

32. Diagnostic Accuracy of Cone Beam CT for Dimensional Linear Measurements in the Mandible
    M Halperin-Sternfeld, EE Machtei, J Horwitz, International Journal of Oral and Maxillofacial Implants 29(3) (2014)

33. Tooth Preservation or Implant Placement: A Systematic Review of Long-Term Survival Rates
    L Levin, M Halperin-Sternfeld, Journal of the American Dental Association 144(10), 1119–1133 (2013)

34. Do We Really Know How to Evaluate Tooth Prognosis? A Systematic Review and Suggested Approach
    M Halperin-Sternfeld, L Levin, Quintessence International 44(5) (2013)

The Halperin-Sternfeld Lab investigates the fundamental biological processes that govern bone regeneration, with a focus on how immune regulation and redox balance shape bone healing in health and disease. We study the interactions between macrophages, mesenchymal stem cells, and the bone-marrow microenvironment, examining how oxidative stress, mitochondrial dysfunction, and inflammaging impair normal bone formation and disrupt the resolution of inflammation. By integrating osteoimmunology, redox biology, and advanced in vivo models of bone repair, our laboratory aims to elucidate the mechanisms underlying bone regeneration and develop strategies to restore bone healing in health, aging and in periodontal diseases.