פרופ' מרדכי [מוטי] גרליץ

2002-2006            Kreitman PhD Fellow - Predoctoral trainee in microbiology and immunology, Ben-gurion university, Israel

2008-2011            CCFA Fellow - Postdoctoral trainee in cell death, inflammation.

2011-2014            Senior Research Officer, Inflammation Division, Walter and Eliza Hall Institute of Medical Research, 3052, VIC, Australia.

2011-2014            Honorary appointment, Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia.

2014-pres             Senior lecturer (Lab head), Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv University.

מטרת המעבדה שלנו היא חקר מנגנונים אשר מבקרים את התהליך הדלקתי כתוצאה מפעילות תאי מערכת החיסון בזמן רגיעה ומחלה. עיקר ההתמקדות הוא על שני תהליכי מוות מתוכנן שמובילים למצב דלקתי, מוות תאי שתלוי באינזים Caspase1 ונקרא פירופטוזיס, Pyroptosis, ומוות נוסף שתלוי בקינאז RIPK3 ולא תלוי בפעילות של Caspases ונקרא נקרורופטוזיס, Necroptosis.

בפרוייקטים אלו אנו נעזרים במקוון שיטות הכוללות עבודה עם תרביות תאים,  עכברים טרנסגניים ייחודיים, ביולוגיה מולקולרית, ביוכימיה,  פרוטאומיקה, במטרה להוביל  לפריצת דרך בתחום של מוות תאי ומחלות מדבקות ע"י חשיפת רבדים חדשים ברגולציה של תהליכים הלו ותפקידם במהלך תגובת מערכת החיסון להדבקות וירליות וחיידקיות.

Complete list of published work at My Bibliography:

http://www.ncbi.nlm.nih.gov/pubmed/?term=Gerlic+M

1. Murphy AJ, Kraakman MJ, Kammoun HL, Dragoljevic D, Lee MK, Lawlor KE, Wentworth JM, Vasanthakumar A, Gerlic M, Whitehead LW, DiRago L, Cengia L, Lane RM, Metcalf D, Vince JE, Harrison LC, Kallies A, Kile BT, Croker BA, Febbraio MA, Masters SL. IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome. Cell Metab, January 2016. PMID: 26603191
2. Uboldi AD, McCoy JM, Blume M, Gerlic M, Ferguson DJ, Dagley LF, Beahan CT, Stapleton DI, Gooley PR, Bacic A, Masters SL, Webb AI, McConville MJ, Tonkin CJ. Regulation of Starch Stores by a Ca(2+)-Dependent Protein Kinase Is Essential for Viable Cyst Development in Toxoplasma gondii. Cell Host Microbe. December 2015. PMID: 26651943
3. Blume M, Nitzsche R, Sternberg U, Gerlic M, Masters SL, Gupta N, McConville MJ. The gluconeogenic enzyme fructose bisphosphatase regulates glucose catabolism in Toxoplasma gondii and is essential for replication and virulence, CELL-HOST-MICROBE-D-14-00707R2, Cell host & Microbe, August 2015. PMID: 26269956
4. Lawlor KE, Khan N, Mildenhall A, Gerlic M, Croker BA, D’Cruz AA, Hall C, Spall SK, Anderton H, Masters SL, Rashidi M, Wicks IP, Alexander WS, Mitsuuchi Y, Benetatos CA, Condon SM, Wong WWL, Silke J, Vaux DL, Vince JE. RIPK3 promotes cell death, NLRP3 inflammasome and interleukin-1 activation in the absence of MLKL, Nature Communication, February 2015. PMID: 25693118
5. O’Donnell JA, Kennedy CL, Pellegrini M, Nowell CJ, Cengia L, Masters SL, Hartland EL, Roberts AW, Gerlic M, Croker BA. Fas controls neutrophil lifespan during viral and bacterial infection. Journal of Leukocyte Biology, December 2014. PMID: 25473101
6. Rickard JA*, O’Donnell JA*, Evans JM*, Lalaoui N, Poh AR, Rogers T, Vince JE, Lawlor KE, Ninnis RL, Anderton H, Hall C, Spall SK, Phesse TJ, Abud HE, Cengia LH, Corbin J, Mifsud S, Di Rago L, Metcalf D, Ernst M, Dewson G, Roberts AW, Alexander WS, Murphy JM, Ekert PG, Masters SL, Vaux DL, Croker BA*, Gerlic M*#, Silke J*#. RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis. Cell, 157 (5), 1175-1188, May 22, 2014 *These authors contributed equally to this work. # Corresponding authors. PMID: 24813849
7. Correa RG, Krajewska M, Ware CF, Gerlic M, Reed JC. The novel NLR-related protein NWD1 is associated with prostate cancer progression and impacts androgen receptor signalling. Oncotarget. March 26, 2014. PMID: 24681825
8. Gerlic M, Croker BA, Cengia LH, Moayeri M, Kile BT, Masters SL. NLRP1a expression in Srebp1a deficient mice. Cell Metabolism, March 4, 2014. PMID: 24606891
9. Gerlic M*, Faustin B*, Postigo A, Yu ECW, Gombosuren N, Krajewska M, Flynn R, Croft M, Way M, Satterthwait A, Liddington RC, Salek-Ardakani S, and Reed JC. Vaccinia Virus F1L protein promotes virulence by inhibiting NLR inflammasome activation. PNAS, April 19, 2013 doi: 10.1073/pnas.1215995110. *These authors contributed equally to this work. PMID: 23603272
10. Proell M, Gerlic M, Mace PD, Reed JC, Riedl SJ. The CARD plays a critical role in ASC foci formation: New insights into inflammasome signaling. Biochem Journal, PMID 23110696, 2012 October. PMID: 23110696
11. Masters SL*, Gerlic M*, Metcalf M, Preston S, Pellegrini M, O’Donnell JA, McArthur K, Baldwin TM, Chevrier S, Nowell CJ, Cengia LH, Henley KJ, Collinge JE, Kastner DL, Feigenbaum L, Hilton DJ, Alexander WS, Kile BT*, Croker BA*. NLRP1 inflammasome induces pyroptosis of hematopoietic progenitor cells. Immunity, Volume 37, Issue 6, 1009-1023, 14 December 2012. *These authors contributed equally to this work. PMID: 23219391
12. Haneklaus M, Gerlic M, Kurowska-Stolarska M, Rainey AA, Pich D, McInnes IB, Hammerschmidt W, O'Neill LA, Masters SL. Cutting Edge: miR-223 and EBV miR-BART15 Regulate the NLRP3 Inflammasome and IL-1β Production. J Immunol. 2012 Oct 15;189(8):3795-9. doi: 10.4049/jimmunol.1200312. Epub 2012 Sep 14. PMID: 22984081
13. Correa RG, Khan PM, Askari N, Zhai D, Gerlic M, Brown B, Magnuson G, Spreafico R, Albani S, Sergienko E, Diaz PW, Roth GP, Reed JC. Discovery and characterization of 2-aminobenzimidazole derivatives as selective NOD1 inhibitors. Chem Biol. 2011 Jul 29;18(7):825-32. PMID: 21802003
14. Yu E, Zhai D, Jin C, Gerlic M, Reed JC, Liddington R. Structural determinants of caspase-9 inhibition by the vaccinia virus protein, F1L. J Biol Chem. 2011 Sep 2;286(35):30748-58. Epub 2011 Jul 11. PMID: 21757755
15. Garrison JB, Correa RG, Gerlic M, Yip KW, Krieg A, Tamble CM, Shi R, Welsh K, Duggineni S, Huang Z, Ren K, Du C, Reed JC. ARTS and Siah collaborate in a pathway for XIAP degradation. Mol Cell. 2011 January;41(1):107-16. Epub 2010 Dec 23. PMID: 21185211
16. Yip KW, Godoi PH, Zhai D, Garcia X, Cellitti JF, Cuddy M, Gerlic M, Chen Y, Satterthwait A, Vasile S, Sergienko E, Reed JC. A TR3/Nur77 peptide-based high-throughput fluorescence polarization screen for small molecule Bcl-B inhibitors. J Biomol Screen. 2008 Aug;13(7):665-73. doi: 10.1177/1087057108320918. Epub 2008 Jul 14. PMID: 18626112
17. Gerlic M, Horowitz J, Farkash S, Horowitz S. The inhibitory effect of Mycoplasma fermentans on tumour necrosis factor (TNF)-alpha-induced apoptosis resides in the membrane lipoproteins. Cell Microbiol. 2007 Jan;9(1):142-53. Epub 2006 Aug 2. PMID: 16889623
18. Gerlic M, Horowitz J, Horowitz S. Mycoplasma fermentans inhibits tumor necrosis factor alpha-induced apoptosis in the human myelomonocytic U937 cell line. Cell Death Differ. 2004 Nov;11(11):1204-12. PMID: 15286682

Reviews:

1. Silke J, Rickard JA, Gerlic M*. The diverse role of RIP kinases in necroptosis and inflammation. Nature Immunology, 2015 Jul;16(7):689-97. doi: 10.1038/ni.3206. Review. Erratum in: Nat Immunol. 2015 Aug;16(8):889. PMID: 26086143
2. Croker BA, Silke J, Gerlic M. Fight or flight: regulation of emergency hematopoiesis by pyroptosis and necroptosis, Current Opinion in Hematology, June, 2015, 22 (4), 293-301, DOI:10.1097/MOH.0000000000000148. PMID: 26049749
3. Gerlic M, Masters SL. A healthy appetite for Toxoplasma at the cellular level. Immunology and Cell Biology, Nevember 2014, 92 (10), 813-814. PMID: 25178968
4. Croker BA, O’Donnell JA, Gerlic M. Pyroptotic death storms and cytopenia. Current Opinion in Immunology (Invited review), 2014 Feb;26:128-37. doi: 10.1016/j.coi.2013.12.002. Epub 2013 Dec 22. PMID: 24556409
5. Haneklaus M*, Gerlic M*, O'Neill LA, Masters SL. miR-223: infection, inflammation and cancer, J Intern Med. 2013 Sep;274(3):215-26. doi: 10.1111/joim.12099. Epub 2013 Jun 25. *These authors contributed equally to this work. PMID: 23772809