פרופ' דרורית נוימן

סגל אקדמי בכיר בביולוגיה תאית והתפתחותית
מופקד על קתדרה בדיקאנט ומנהל הפקולטה לרפואה
דקאן בדיקאנט הסטודנטים
ביולוגיה תאית והתפתחותית סגל אקדמי בכיר
פרופ' דרורית נוימן
טלפון פנימי: 03-6407256
טלפון נוסף: 03-6405939
פקס: 03-6407432
משרד: רפואה, 316

מחקר



עבודתנו מתמקדת באריתרופוייטין ((EPO, ההורמון העיקרי אשר מווסת את הייצור של כדוריות הדם האדומות, ומפעיל לשם כך את הקולטן שלו ( (EPO-Rאשר מבוטא על פני קרום תאי המוצא בשורה האדומה, האריתרואידית. באופן בלתי צפוי גילינו כי בנוסף לפעילותו באריתרופויאזה יש ל-EPO גם פעילות כנגד גידולים סרטניים, כנראה דרך מנגנונים המווסתים פעילות של מערכת החיסון. התגלית המיוחדת הזאת שלנו הצביעה על כך ש EPO הינו הורמון בעל תכונות פליאוטרופיות. בעקבות תגלית זו התעורר עניין מיוחד בפיתוח המחקר על EPO, תוך דגש על איתור תאי המטרה ופענוח מנגנוני ההפעלה של הקולטן.

 

וויסות רמות הקולטן שעל פני קרום התא והעברת אותות דרכו

מחקרים שונים שהתפרסמו בעבר, כולל אלה ממעבדתנו, הצביעו על כך שEPO-R מתבטא על פני קרום התא ברמות שהן באופן מיוחד נמוכות, בניגוד לנוכחותו ברמות גבוהות בתוך התא. המנגנונים האחראיים לתופעה מיוחדת זו אינם ידועים עדיין, והמחקר בתחום זה מהווה נושא מרכזי בעבודתנו.

פענוח המנגנונים המולקולריים אשר מווסתים את מידת הביטוי של EPO-R על פני התא עשוי לגלות מתכונת חדשה של וויסות העברת האותות באמצעות הקולטן. כתוצאה מכך, תהיינה השלכות לגבי פיתוח דרכים כיצד להתגבר על מצבים שבהם הקולטן מופיע ברמות נמוכות על פני התא; תופעה המהווה כיום אתגר מרכזי, והגבלה בתכנון גישות במחקר

 

EPO כהורמון אימונומודולטורי

על סמך ממצאים מעבודת המחקר שלנו אנו משערים שההורמון, בד בבד עם תכונותיו הידועות היטב לגבי המטופויאזה, ממלא גם תפקיד רחב יותר, כפי שבא לידי ביטוי בפעילות אנטי סרטנית, כפי שנצפה במחקרים שלנו על חולי מיאלומה (multiple myeloma). ההורמון עשוי לשמש אם כך כאמצעי טיפול חשוב בחולי מיאלומה ואולי גם במחלות ממאירות אחרות, וכן גם בהגברת המערכת החיסונית. בהתאם לכך, המחקר המתבצע במעבדתנו מתוכנן כדי לברר האם ההורמון אכן פעיל כתכשיר אנטי-סרטני ומהי דרך פעילותו על מערכת החיסון. עבודה זו מתבצעת בשיתוף פעולה עם פרופ' מיטלמן, במרכז הרפואי סוראסקי, ת"א.

ביסוס הראיות על השפעות EPO על גידולים סרטניים והמידע שיושג על פעילותו במערכת החיסון יפתחו דרכים חדשניות לטיפול במחלות ממאירות המטולוגיות ואחרות. יתרה מזו, לתוצאות עשויות להיות השלכות גם לגבי טיפול במצבים שונים של כשל חיסוני, וכן כטיפול חדשני בחולים בממאירויות שונות.

 

 

Research

Erythropoietin and Its Receptor in Health and Disease – Basic and Clinical Aspects

 

Our research focuses on erythropoietin (EPO), the primary hormone that regulates erythropoiesis by activating its cell surface receptor (EPO-R) on erythroid progenitor cells. Our decision to work on this EPO/EPO-R system was motivated by its potential as a model for understanding the basic mechanisms of hormone-receptor function and regulation. Through this research, we made a novel, original discovery, together with Prof. Mittelman from the Sourasky Medical Center, suggesting that EPO may actually act as a pleiotropic hormone with anti-neoplastic, immunomodulatory activities. In collaboration with Prof. Yankel Gabet, we have shown that EPO administration is associated with significant bone loss. We are currently focusing on deciphering the underlying mechanisms. 

 

Our research is thus focused on both the basic mechanisms of hormone-receptor interaction and the function of this hormone as an immunomodulator and an interface with bone metabolism. The studies are based on a variety of in vitro and murine experimental models, providing a basis for elucidating the relevance and potential clinical applications of the results.

 

Publications

 

2025 | Erythropoietin controls surface expression of its receptor via endoplasmic reticulum translocation
Graniewitz Visacovsky, L., Ben-Califa, N., Neumann, D. & Stanhill, A., 12 Sep 2025, In: Biochemical and Biophysical Research Communications. 779, 152414.


Immunomodulatory function of cannabinoid receptor 2 and its agonist osteogenic growth peptide in health and cancer: a study in mice and humans
Iden, J. A., Ben-Califa, N., Naim, A., Liron, T., Neumann, D. & Gabet, Y., 4 Aug 2025, In: Oncogene. 44, 29, p. 2504-2514 11 p.
 

2023 | EpoR Activation Stimulates Erythroid Precursor Proliferation by Inducing Phosphorylation of Tyrosine-88 of the CDK-Inhibitor p27Kip1
Pegka, F., Ben-Califa, N., Neumann, D., Jäkel, H. & Hengst, L., Jul 2023, In: Cells. 12, 13, 1704.


The Anti-Tumorigenic Role of Cannabinoid Receptor 2 in Non-Melanoma Skin Cancer
Iden, J. A., Raphael-Mizrahi, B., Naim, A., Kolomansky, A., Liron, T., Neumann, D., Vered, M. & Gabet, Y., May 2023, In: International Journal of Molecular Sciences. 24, 9, 7773.

2022 | Erythropoietin Receptor (EPOR) Signaling in the Osteoclast Lineage Contributes to EPO-Induced Bone Loss in Mice
Awida, Z., Hiram-Bab, S., Bachar, A., Saed, H., Zyc, D., Gorodov, A., Ben-Califa, N., Omari, S., Omar, J., Younis, L., Iden, J. A., Graniewitz Visacovsky, L., Gluzman, I., Liron, T., Raphael-Mizrahi, B., Kolomansky, A., Rauner, M., Wielockx, B., Gabet, Y. & Neumann, D., Oct 2022, In: International Journal of Molecular Sciences. 23, 19, 12051.

Erythropoietin receptor regulates tumor mitochondrial biogenesis through iNOS and pAKT
Aboouf, M. A., Guscetti, F., von Büren, N., Armbruster, J., Ademi, H., Ruetten, M., Meléndez-Rodríguez, F., Rülicke, T., Seymer, A., Jacobs, R. A., Schneider Gasser, E. M., Aragones, J., Neumann, D., Gassmann, M. & Thiersch, M., 16 Aug 2022, In: Frontiers in Oncology. 12, 976961.
 
The non-erythropoietic EPO analogue cibinetide inhibits osteoclastogenesis in vitro and increases bone mineral density in mice
Awida, Z., Bachar, A., Saed, H., Gorodov, A., Ben-Califa, N., Ibrahim, M., Kolomansky, A., Iden, J. A., Visacovsky, L. G., Liron, T., Hiram-Bab, S., Brines, M., Gabet, Y. & Neumann, D., 1 Jan 2022, In: International Journal of Molecular Sciences. 23, 1, 55.

2021 | Editorial: Developmental Biology and Regulation of Osteoclasts
Gabet, Y., Neumann, D., Levaot, N., Elson, A. & Sims, N. A., 22 Oct 2021, In: Frontiers in Cell and Developmental Biology. 9, 769320.

Epo/EpoR signaling in osteoprogenitor cells is essential for bone homeostasis and Epo-induced bone loss
Rauner, M., Murray, M., Thiele, S., Watts, D., Neumann, D., Gabet, Y., Hofbauer, L. C. & Wielockx, B., Dec 2021, In: Bone Research. 9, 1, 42.

Erythropoietin Treatment Is Associated with Decreased Blood Glucose Levels in Hematologic Patients
Oster, H. S., Gvili Perelman, M., Kolomansky, A., Neumann, D. & Mittelman, M., May 2021, In: Acta Haematologica. 144, 3, p. 252-258 7 p.

Article has an altmetric score of 2
Quantification of Osteoclasts in Culture, Powered by Machine Learning
Cohen-Karlik, E., Awida, Z., Bergman, A., Eshed, S., Nestor, O., Kadashev, M., Yosef, S. B., Saed, H., Mansour, Y., Globerson, A., Neumann, D. & Gabet, Y., 25 May 2021, In: Frontiers in Cell and Developmental Biology. 9, 674710.

2020 | Anti-CD20-Mediated B Cell Depletion Is Associated With Bone Preservation in Lymphoma Patients and Bone Mass Increase in Mice
Kolomansky, A., Kaye, I., Ben-Califa, N., Gorodov, A., Awida, Z., Sadovnic, O., Ibrahim, M., Liron, T., Hiram-Bab, S., Oster, H. S., Sarid, N., Perry, C., Gabet, Y., Mittelman, M. & Neumann, D., 19 Oct 2020, In: Frontiers in Immunology. 11, 561294.

Erythropoietin mediated bone loss in mice is dose-dependent and mostly irreversible
Kolomansky, A., Hiram-Bab, S., Ben-Califa, N., Liron, T., Deshet-Unger, N., Mittelman, M., Oster, H. S., Rauner, M., Wielockx, B., Neumann, D. & Gabet, Y., 1 Jun 2020, In: International Journal of Molecular Sciences. 21, 11, 3817.

Erythropoietin receptor in B cells plays a role in bone remodeling in mice
Deshet-Unger, N., Kolomansky, A., Ben-Califa, N., Hiram-Bab, S., Gilboa, D., Liron, T., Ibrahim, M., Awida, Z., Gorodov, A., Oster, H. S., Mittelman, M., Rauner, M., Wielockx, B., Gabet, Y. & Neumann, D., 2020, In: Theranostics. 10, 19, p. 8744-8756 13 p.

2018 | Erythropoietin (EPO) Regulates Bone Mass Via EPO Receptors on Myeloid and Lymphocytic Cells
Hiram-Bab, S., Kolomansky, A., Deshet-Unger, N., Ben-Califa, N., Liron, T., Rauner, M., Wielockx, B., Mittelman, M., Oster, H. S., Gabet, Y. & Neumann, D., 29 Nov 2018, In: Blood. 132

Response to erythropoietin in pediatric patients with chronic kidney disease: insights from an in vitro bioassay
Gavish, R., Watad, S., Ben-Califa, N., Goldberg, O. J., Haskin, O., Davidovits, M., Koren, G., Falush, Y., Neumann, D. & Krause, I., 1 Nov 2018, In: Pediatric Nephrology. 33, 11, p. 2123-2129 7 p.

2017 | B cell depletion by anti-CD20 antibodies entrains trabecular bone loss in mice.
Kolomansky, A., Deshet-Unger, N., Ostrovsky, A., Hiram-Bab, S., Ben-Califa, N., Liron, T., Oster, H. S., Mittelman, M., Gabet, Y. & Neumann, D., Dec 2017, In: Journal of Bone and Mineral Research. 32, p. S310-S310

Context-Dependent Skeletal Effects of Erythropoietin
Hiram-Bab, S., Neumann, D. & Gabet, Y., 2017, Vitamins and Hormones. Academic Press Inc., p. 161-179 19 p. (Vitamins and Hormones; vol. 105).

Erythropoietin administration is associated with improved T-cell properties in patients with myelodysplastic syndromes
Deshet-Unger, N., Oster, H. S., Prutchi-Sagiv, S., Maaravi, N., Golishevski, N., Neumann, D. & Mittelman, M., 1 Jan 2017, In: Leukemia Research. 52, p. 20-27 8 p.

Erythropoietin enhances Kupffer cell number and activity in the challenged liver
Gilboa, D., Haim-Ohana, Y., Deshet-Unger, N., Ben-Califa, N., Hiram-Bab, S., Reuveni, D., Zigmond, E., Gassmann, M., Gabet, Y., Varol, C. & Neumann, D., 1 Dec 2017, In: Scientific Reports. 7, 1, 10379.

Erythropoietin in bone – Controversies and consensus
Hiram-Bab, S., Neumann, D. & Gabet, Y., 1 Jan 2017, In: Cytokine. 89, p. 155-159 5 p.

Pharmacological B Cell Depletion by Anti-CD20 Antibody Induces Trabecular Bone Loss in Mice
Kolomansky, A., Deshet-Unger, N., Ostrovsky, A., Ben-Califa, N., Hiram-Bab, S., Liron, T., Oster, H., Mittelman, M., Gabet, Y. & Neumann, D., Sep 2017, In: Clinical Lymphoma, Myeloma and Leukemia. 17, p. S377-S378

2016 | Erythropoietin treatment in murine multiple myeloma: Immune gain and bone loss
Deshet-Unger, N., Hiram-Bab, S., Haim-Ohana, Y., Mittelman, M., Gabet, Y. & Neumann, D., 2 Aug 2016, In: Scientific Reports. 6, 30998.

Increased EPO Levels Are Associated With Bone Loss in Mice Lacking PHD2 in EPO-Producing Cells
Rauner, M., Franke, K., Murray, M., Singh, R. P., Hiram-Bab, S., Platzbecker, U., Gassmann, M., Socolovsky, M., Neumann, D., Gabet, Y., Chavakis, T., Hofbauer, L. C. & Wielockx, B., 1 Oct 2016, In: Journal of Bone and Mineral Research. 31, 10, p. 1877-1887 11 p.

Transdifferentiation of Bone Marrow Pro-B Cells into Bone-Resorbing Osteoclasts-an Unexpected Role for Erythropoietin
Deshet-Unger, N., Hiram-Bab, S., Ben-Califa, N., Gilboa, D., Liron, T., Albert, K., Oster, H. S., Mittelman, M., Gabet, Y. & Neumann, D., 2 Dec 2016, In: Blood. 128, 22

2015 | Erythropoietin directly stimulates osteoclast precursors and induces bone loss
Hiram-Bab, S., Liron, T., Deshet-Unger, N., Mittelman, M., Gassmann, M., Rauner, M., Franke, K., Wielockx, B., Neumann, D. & Gabet, Y., 1 May 2015, In: FASEB Journal. 29, 5, p. 1890-1900 11 p.

Novel antibodies directed against the human erythropoietin receptor: Creating a basis for clinical implementation
Maxwell, P., Melendez-Rodríguez, F., Matchett, K. B., Aragones, J., Ben-Califa, N., Jaekel, H., Hengst, L., Lindner, H., Bernardini, A., Brockmeier, U., Fandrey, J., Grunert, F., Oster, H. S., Mittelman, M., El-Tanani, M., Thiersch, M., Schneider Gasser, E. M., Gassmann, M., Dangoor, D. & Cuthbert, R. J. & 5 others, , 1 Feb 2015, In: British Journal of Haematology. 168, 3, p. 429-442 14 p.

Salarin C inhibits the maintenance of chronic myeloid leukemia progenitor cells
Del Poggetto, E., Tanturli, M., Ben-Califa, N., Gozzini, A., Tusa, I., Cheloni, G., Marzi, I., Cipolleschi, M. G., Kashman, Y., Neumann, D., Rovida, E. & Dello Sbarba, P., 2015, In: Cell Cycle. 14, 19, p. 3146-3154 9 p.

2014 | EPO-independent functional EPO receptor in breast cancer enhances estrogen receptor activity and promotes cell proliferation
Reinbothe, S., Larsson, A. M., Vaapil, M., Wigerup, C., Sun, J., Jögi, A., Neumann, D., Rönnstrand, L. & Påhlman, S., 28 Feb 2014, In: Biochemical and Biophysical Research Communications. 445, 1, p. 163-169 7 p.

Genetic Basis of Congenital Erythrocytosis: Mutation Update and Online Databases
Bento, C., Percy, M. J., Gardie, B., Maia, T. M., van Wijk, R., Perrotta, S., Della Ragione, F., Almeida, H., Rossi, C., Girodon, F., Åström, M., Neumann, D., Schnittger, S., Landin, B., Minkov, M., Randi, M. L., Richard, S., Casadevall, N., Vainchenker, W. & Rives, S. & 4 others, , Jan 2014, In: Human Mutation. 35, 1, p. 15-26 12 p.
Research output: Contribution to journal › Article › peer-review

Polycythaemia-inducing mutations in the erythropoietin receptor (EPOR): Mechanism and function as elucidated by epidermal growth factor receptor-EPOR chimeras
Gross, M., Ben-Califa, N., Mcmullin, M. F., Percy, M. J., Bento, C., Cario, H., Minkov, M. & Neumann, D., May 2014, In: British Journal of Haematology. 165, 4, p. 519-528 10 p.

Resistance of LPS-activated bone marrow derived macrophages to apoptosis mediated by dexamethasone
Haim, Y. O., Unger, N. D., Souroujon, M. C., Mittelman, M. & Neumann, D., 10 Mar 2014, In: Scientific Reports. 4, 4323.

⁨נוימן, ד.⁩, 2014, In: ידיאופ: האוניברסיטה הפתוחה. 2, p. 50-51 2 p.

2013 | Derivatives of salarin A, salarin C and tulearin A - Fascaplysinopsis sp. metabolites
Zur, L. G., Bishara, A., Aknin, M., Neumann, D., Ben-Califa, N. & Kashman, Y., Nov 2013, In: Marine Drugs. 11, 11, p. 4487-4509 23 p.

Erythropoietin
Ohana, Y. H., Liron, T., Prutchi-Sagiv, S., Mittelman, M., Souroujon, M. C. & Neumann, D., 2013, Handbook of Biologically Active Peptides. Elsevier Inc., p. 1619-1626 8 p.

Erythropoietin treatment is associated with an augmented immune response to the influenza vaccine in hematologic patients
Oster, H. S., Prutchi-Sagiv, S., Halutz, O., Shabtai, E., Hoffman, M., Neumann, D. & Mittelman, M., Feb 2013, In: Experimental Hematology. 41, 2, p. 167-171 5 p.

2012 | Erythropoietin: The swinging pendulum
Oster, H. S., Neumann, D., Hoffman, M. & Mittelman, M., Aug 2012, In: Leukemia Research. 36, 8, p. 939-944 6 p.

Erythropoietin-driven signalling and cell migration mediated by polyADP-ribosylation
Inbar, D., Cohen-Armon, M. & Neumann, D., 9 Oct 2012, In: British Journal of Cancer. 107, 8, p. 1317-1326 10 p.

Salarin C, a member of the salarin superfamily of marine compounds, is a potent inducer of apoptosis
Ben-Califa, N., Bishara, A., Kashman, Y. & Neumann, D., Feb 2012, In: Investigational New Drugs. 30, 1, p. 98-104 7 p.

2011  |  Cytosolic lysine residues enhance anterograde transport and activation of the erythropoietin receptor
Yosha, L., Ravid, O., Ben-Califa, N. & Neumann, D., 15 Apr 2011, In: Biochemical Journal. 435, 2, p. 509-518 10 p.

Erythropoietin receptor is detectable on peripheral blood lymphocytes and its expression increases in activated t lymphocytes (reply)
Neumann, D., Prutchi-Sagiv, S., Lifshitz, L. & Mittelman, M., Mar 2011, In: Haematologica. 96, 3, p. 14 1 p.

2010 | Erythropoietin and cyclophosphamide combination treatment additively enhances antibody production in mice
Lifshitz, L., Berger, A., Mittelman, M. & Neumann, D., Feb 2010, In: Acta Haematologica. 123, 2, p. 81-83 3 p.

Erythropoietin and cyclophosphamide combination treatment additively enhances immunoglobulin production in mice
Berger, A., Lifshitz, L., Mittelman, M. & Neumann, D., Oct 2010, In: Israel Medical Association Journal. 12, 10, p. 647 1 p.

Erythropoietin treatment leads to reduced blood glucose levels and body mass: Insights from murine models
Katz, O., Stuible, M., Golishevski, N., Lifshitz, L., Tremblay, M. L., Gassmann, M., Mittelman, M. & Neumann, D., Apr 2010, In: Journal of Endocrinology. 205, 1, p. 87-95 9 p.

Insertion of an NPVY sequence into the cytosolic domain of the erythropoietin receptor selectively affects erythropoietin-mediated signalling and function
Liron, T., Nahari, T., Souroujon, M. C. & Neumann, D., 15 Apr 2010, In: Biochemical Journal. 427, 2, p. 305-312 8 p.

Macrophages as novel target cells for erythropoietin
Lifshitz, L., Tabak, G., Gassmann, M., Mittelman, M. & Neumann, D., Nov 2010, In: Haematologica. 95, 11, p. 1823-1831 9 p.

Salarins D-J, seven new nitrogenous macrolides from the madagascar sponge Fascaplysinopsis sp.
Bishara, A., Rudi, A., Aknin, M., Neumann, D., Ben-Califa, N. & Kashman, Y., 12 Jun 2010, In: Tetrahedron. 66, 24, p. 4339-4345 7 p.

The lower risk MDS patient at risk of rapid progression
Mittelman, M., Oster, H. S., Hoffman, M. & Neumann, D., Dec 2010, In: Leukemia Research. 34, 12, p. 1551-1555 5 p.

2009  |  Non-erythroid activities of erythropoietin: Functional effects on murine dendritic cells
Lifshitz, L., Prutchi-Sagiv, S., Avneon, M., Gassmann, M., Mittelman, M. & Neumann, D., Feb 2009, In: Molecular Immunology. 46, 4, p. 713-721 9 p.

Non-erythroid effects of erythropoietin: Are neutrophils a target?
Avneon, M., Lifshitz, L., Katz, O., Prutchi-Sagiv, S., Gassmann, M., Mittelman, M. & Neumann, D., Oct 2009, In: Leukemia Research. 33, 10, p. 1430-1432 3 p.

2009  |  Tausalarin C: A new bioactive marine sponge-derived nitrogenous bismacrolide
Bishara, A., Rudi, A., Goldberg, I., Aknin, M., Neumann, D., Ben-Califa, N. & Kashman, Y., 20 Aug 2009, In: Organic Letters. 11, 16, p. 3538-3541 4 p.

2008  |  A transplanted NPVY sequence in the cytosolic domain of the erythropoietin receptor enhances maturation
Nahari, T., Barzilay, E., Hirschberg, K. & Neumann, D., 1 Mar 2008, In: Biochemical Journal. 410, 2, p. 409-416 8 p.


Erratum to "Salarin C, a new cytoxic sponge-derived nitrogenous macrolide" [Tetrahedron Lett. 49 (2008) 4355] (DOI:10.1016/j.tetlet.2008.05.038)
Bishara, A., Rudi, A., Aknin, M., Neumann, D., Ben-Califa, N. & Kashman, Y., 8 Sep 2008, In: Tetrahedron Letters. 49, 37, p. 5437 1 p.

Erythropoietin effects on dendritic cells: Potential mediators in its function as an immunomodulator?
Sagiv, S. P., Lifshitz, L., Orkin, R., Mittelman, M. & Neumann, D., Dec 2008, In: Experimental Hematology. 36, 12, p. 1682-1690 9 p.

Salarin C, a new cytotoxic sponge-derived nitrogenous macrolide
Bishara, A., Rudi, A., Aknin, M., Neumann, D., Ben-Califa, N. & Kashman, Y., 7 Jul 2008, In: Tetrahedron Letters. 49, 28, p. 4355-4358 4 p.

Salarins A and B and tulearin A: New cytotoxic sponge-derived macrolides
Bishara, A., Rudi, A., Aknin, M., Neumann, D., Ben-Califa, N. & Kashman, Y., 17 Jan 2008, In: Organic Letters. 10, 2, p. 153-156 4 p.

Taumycins a and B, Two bioactive lipodepsipeptides from the Madagascar sponge Fascaplysinopsis sp
Bishara, A., Rudi, A., Aknin, M., Neumann, D., Ben-Califa, N. & Kashman, Y., 2008, In: Organic Letters. 10, 19, p. 4307-4309 3 p.

2007  |  An extracellular region of the erythropoietin receptor of the subterranean blind mole rat Spalax enhances receptor maturation
Ravid, O., Shams, I., Califa, N. B., Nevo, E., Avivi, A. & Neumann, D., 4 Sep 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 36, p. 14360-14365 6 p.

Erythropoietin enhances immune responses in mice
Katz, O., Gil, L., Lifshitz, L., Prutchi-Sagiv, S., Gassmann, M., Mittelman, M. & Neumann, D., Jun 2007, In: European Journal of Immunology. 37, 6, p. 1584-1593 10 p.

Nuttingins A-F and malonganenones D-H, tetraprenylated alkaloids from the tanzanian gorgonian Euplexaura nuttingi
Sorek, H., Rudi, A., Benayahu, Y., Ben-Califa, N., Neumann, D. & Kashman, Y., Jul 2007, In: Journal of Natural Products. 70, 7, p. 1104-1109 6 p.
Research output: Contribution to journal › Article › peer-review

Overexpression of amyloid precursor protein reduces epsilon protein kinase C levels
Liron, T., Seraya, C. B., Ish-Shalom, M., Souroujon, M. C. & Neumann, D., 25 Apr 2007, In: Neuroscience. 146, 1, p. 152-159 8 p.

2006 | Erythropoietin-A Hematopoietic Hormone With Emerging Diverse Activities
Prutchi-Sagiv, S., Mittleman, M. & Neumann, D., 2006, Handbook of Biologically Active Peptides. Elsevier Inc., p. 1393-1400 8 p.

Erythropoietin in clinical practice: Current use, effect on survival, and future directions
Oster, H. S., Hoffman, M., Prutchi-Sagiv, S., Katz, O., Neumann, D. & Mittelman, M., Oct 2006, In: Israel Medical Association Journal. 8, 10, p. 703-706 4 p.

Erythropoietin treatment in advanced multiple myeloma is associated with improved immunological functions: Could it be beneficial in early disease?
Prutchi-Sagiv, S., Golishevsky, N., Oster, H. S., Katz, O., Cohen, A., Naparstek, E., Neumann, D. & Mittelman, M., Dec 2006, In: British Journal of Haematology. 135, 5, p. 660-672 13 p.

2005 | Erythropoietin induced tumour mass reduction in murine lymphoproliferative models
Katz, O., Barzilay, E., Skaat, A., Herman, A., Mittelman, M. & Neumann, D., Oct 2005, In: Acta Haematologica. 114, 3, p. 177-179 3 p.
Research output: Contribution to journal › Article › peer-review

Generation of a novel anti-geldanamycin antibody
Barzilay, E., Ben-Califa, N., Shahar, M., Kashman, Y. & Neumann, D., 6 May 2005, In: Biochemical and Biophysical Research Communications. 330, 2, p. 561-564 4 p.

Uncoupling of brefeldin A-mediated coatomer protein complex-I dissociation from Golgi redistribution
Barzilay, E., Ben-Califa, N., Hirschberg, K. & Neumann, D., Sep 2005, In: Traffic. 6, 9, p. 794-802 9 p.

2004 | Erythropoietin has an anti-myeloma effect - A hypothesis based on a clinical observation supported by animal studies
Mittelman, M., Zeidman, A., Kanter, P., Katz, O., Oster, H., Rund, D. & Neumann, D., Mar 2004, In: European Journal of Haematology. 72, 3, p. 155-165 11 p.

Geldanamycin-associated Inhibition of Intracellular Trafficking Is Attributed to a Co-purified Activity
Barzilay, E., Ben-Califa, N., Supino-Rosin, L., Kashman, Y., Hirschberg, K., Elazar, Z. & Neumann, D., 20 Feb 2004, In: Journal of Biological Chemistry. 279, 8, p. 6847-6852 6 p.

Protein tyrosine phosphatase 1B participates in the down-regulation of erythropoietin receptor signalling
Cohen, J., Oren-Young, L., Klingmuller, U. & Neumann, D., 15 Jan 2004, In: Biochemical Journal. 377, 2, p. 517-524 8 p.

A functional green fluorescent protein-tagged erythropoietin receptor despite physical separation of JAK2 binding site and tyrosine residues
Ketteler, R., Heinrich, A. C., Offe, J. K., Becker, V., Cohen, J., Neumann, D. & Klingmüller, U., 19 Jul 2002, In: Journal of Biological Chemistry. 277, 29, p. 26547-26552 6 p.

Amino acid residues 268-276 of the erythropoietin receptor contain an endocytosis motif and are required for erythropoietin-mediated proliferation
Flint-Ashtamker, G., Eisen-Lev, R., Cohen, J., Jun-shen Huang, L. & Neumann, D., 8 May 2002, In: FEBS Letters. 518, 1-3, p. 189-194 6 p.

Erythropoietin and its receptor: signaling and clinical manifestations.
Cohen, J., Supino-Rosin, L., Barzilay, E., Eisen-Lev, R., Mittelman, M. & Neumann, D., Nov 2002, In: Israel Medical Association Journal. 4, 11, p. 1072-1076 5 p.

Erythropoietin induces tumor regression and antitumor immune responses in murine myeloma models
Mittelman, M., Neumann, D., Peled, A., Kanter, P. & Haran-Ghera, N., 24 Apr 2001, In: Proceedings of the National Academy of Sciences of the United States of America. 98, 9, p. 5181-5186 6 p.

Self assembly of the transmembrane domain promotes signal transduction through the erythropoietin receptor
Kubatzky, K. F., Ruan, W., Gurezka, R., Cohen, J., Ketteler, R., Watowich, S. S., Neumann, D., Langosch, D. & Klingmüller, U., 23 Jan 2001, In: Current Biology. 11, 2, p. 110-115 6 p.

2000 | Intracellular retention and degradation of the epidermal growth factor receptor, Two distinct processes mediated by benzoquinone ansamycins
Supino-Rosin, L., Yoshimura, A., Yarden, Y., Elazar, Z. & Neumann, D., 21 Jul 2000, In: Journal of Biological Chemistry. 275, 29, p. 21850-21855 6 p.
Research output: Contribution to journal › Article › peer-review

1999 | A cytosolic domain of the erythropoietin receptor contributes to endoplasmic reticulum-associated degradation
Supino-Rosin, L., Yoshimura, A., Altaratz, H. & Neumann, D., 15 Jul 1999, In: European Journal of Biochemistry. 263, 2, p. 410-419 10 p.

1998 | Identification of a cytoplasmic motif in the erythropoietin receptor required for receptor internalization
Levin, I., Cohen, J., Supino-Rosin, L., Yoshimura, A., Watowich, S. S. & Neumann, D., 8 May 1998, In: FEBS Letters. 427, 2, p. 164-170 7 p.
Research output: Contribution to journal › Article › peer-review

1997 | Phosphorylation of erythropoietin receptors in the endoplasmic reticulum by pervanadate-mediated inhibition of tyrosine phosphatases
Cohen, J., Altaratz, H., Zick, Y., Klingmüller, U. & Neumann, D., 15 Oct 1997, In: Biochemical Journal. 327, 2, p. 391-397 7 p.

1996 | Blocking intracellular degradation of the erythropoietin and asialoglycoprotein receptors by calpain inhibitors does not result in the same increase in the levels of their membrane and secreted forms
Neumann, D., Huam Yuk, M., Lodish, H. F. & Lederkremer, G. Z., 15 Jan 1996, In: Biochemical Journal. 313, 2, p. 391-399 9 p.

Erythropoietin stimulates atrial natriuretic peptide secretion from adult rat cardiac atrium
Porat, O., Neumann, D., Zamir, O., Nachshon, S., Feigin, E., Cohen, J. & Zamir, N., Mar 1996, In: Journal of Pharmacology and Experimental Therapeutics. 276, 3, p. 1162-1168 7 p.

1993  |  Activation of the erythropoietin receptor and leukemia induction in mice
Longmore, G., Watowich, S., Pharr, P., Neumann, D. & Lodish, H., 1993, In: Leukemia. 7, SUPPL.2, p. S113-S116

Both megakaryocytopoiesis and erythropoiesis are induced in mice infected with a retrovirus expressing an oncogenic erythropoietin receptor
Longmore, G. D., Pharr, P., Neumann, D. & Lodish, H. F., 15 Oct 1993, In: Blood. 82, 8, p. 2386-2395 10 p.

Intermediates in degradation of the erythropoietin receptor accumulate and are degraded in lysosomes
Neumann, D., Wikström, L., Watowich, S. S. & Lodish, H. F., 25 Jun 1993, In: Journal of Biological Chemistry. 268, 18, p. 13639-13649 11 p.

Molecular Evolution of the Binding Site of the Acetylcholine Receptor
FUCHS, S., BARCHAN, D., KACHALSKY, S., NEUMANN, D., ALADJEM, M., VOGEL, Z., OVADIA, M. & KOCHVA, E., Jun 1993, In: Annals of the New York Academy of Sciences. 681, 1, p. 126-139 14 p.

Structure, function, and activation of the erythropoietin receptor
Youssoufian, H., Longmore, G., Neumann, D., Yoshimura, A. & Lodish, H. F., 1 May 1993, In: Blood. 81, 9, p. 2223-2236 14 p.

1992 | How the mongoose can fight the snake: The binding site of the mongoose acetylcholine receptor
Barchan, D., Kachalsky, S., Neumann, D., Vogel, Z., Ovadia, M., Kochva, E. & Fuchs, S., 1992, In: Proceedings of the National Academy of Sciences of the United States of America. 89, 16, p. 7717-7721 5 p.

Mutations in the Trp-Ser-X-Trp-Ser motif of the erythropoietin receptor abolish processing, ligand binding, and activation of the receptor
Yoshimura, A., Zimmers, T., Neumann, D., Longmore, G., Yoshimura, Y. & Lodish, H. F., 5 Jun 1992, In: Journal of Biological Chemistry. 267, 16, p. 11619-11625 7 p.

T-cell antigenic sites involved in Myasthenia Gravis: Correlations with antibody titre and disease severity
Berrih-Aknin, S., Cohen-Kaminsky, S., Lepage, V., Neumann, D., Bach, J. F. & Fuchs, S., Feb 1991, In: Journal of Autoimmunity. 4, 1, p. 137-153 17 p.

1990 | Acetylcholine receptor gene expression in experimental autoimmune myasthenia gravis
Asher, O., Neumann, D., Witzemann, V. & Fuchs, S., 16 Jul 1990, In: FEBS Letters. 267, 2, p. 231-235 5 p.

1989 | Acetylcholine receptor gene expression in experimental autoimmune myasthenia gravis: Correlation with disease
Fuchs, S., Asher, O. & Neumann, D., 1989, In: Israel Journal of Medical Sciences. 25, 12, p. 690-692 3 p.

Snake acetylcholine receptor: Cloning of the domain containing the four extracellular cysteines of the α subunit
Neumann, D., Barchan, D., Horowitz, M., Kochva, E. & Fuchs, S., 1989, In: Proceedings of the National Academy of Sciences of the United States of America. 86, 18, p. 7255-7259 5 p.

1988 | Cellular aspects of myasthenia gravis
Berrih-Aknin, S., Cohen-Kaminsky, S., Neumann, D., Safar, D., Eymard, B., Gaud, C., Levasseur, P., Fuchs, S. & Bach, J. F., Sep 1988, In: Immunologic Research. 7, 3, p. 189-199 11 p.

Increased levels of acetylcholine receptor α-subunit mRNA in experimental autoimmune myasthenia gravis
Asher, O., Neumann, D. & Fuchs, S., 20 Jun 1988, In: FEBS Letters. 233, 2, p. 277-281 5 p.

In vitro proliferative responses and antibody titers specific to human acetylcholine receptor synthetic peptides in patient with myasthenia gravis and relation to HLA class II genes
Brocke, S., Brautbar, C., Steinman, L., Abramsky, O., Rothbard, J., Neumann, D., Fuchs, S. & Mozes, E., 1988, In: Journal of Clinical Investigation. 82, 6, p. 1894-1900 7 p.

Proliferative Responses to Acetylcholine Receptor Peptides in Myasthenia Gravis
BERRIH‐AKNIN, S., COHEN‐KAMINSKY, S., NEUMANN, D., BACH, J. F. & FUCHS, S., Nov 1988, In: Annals of the New York Academy of Sciences. 540, 1, p. 504-505 2 p.

1987 | Phosphorylation of the acetylcholine receptor by protein kinase C and identification of the phosphorylation site within the receptor delta subunit.
Safran, A., Sagi-Eisenberg, R., Neumann, D. & Fuchs, S., 5 Aug 1987, In: The Journal of biological chemistry. 262, 22, p. 10506-10510 5 p.

Species Specificity of Anti-Acetylcholine Receptor Antibodies Elicited by Synthetic Peptides
Fuchs, S., Neumann, D., Safran, A., Pizzighella, S., Mantegazza, R., Daniels, M. P. & Vogel, Z., 1987, In: Biochemistry. 26, 15, p. 4611-4616 6 p.

Synthetic Peptides and Their Antibodies in the Analysis of the Acetylcholine Receptor
FUCHS, S., NEUMANN, D., SAFRAN, A., SOUROUJON, M., BARCHAN, D., FRIDKIN, M., GERSHONI, J. M., MANTEGAZZA, R. & PIZZIGHELLA, S., Aug 1987, In: Annals of the New York Academy of Sciences. 505, 1, p. 256-271 16 p.

1986 | Analysis of acetylcholine receptor phosphorylation sites using antibodies to synthetic peptides and monoclonal antibodies.
Safran, A., Neumann, D. & Fuchs, S., 1 Dec 1986, In: EMBO Journal. 5, 12, p. 3175-3178 4 p.

1986 | Analysis of ligand binding to the synthetic dodecapeptide 185-196 of the acetylcholine receptor α subunit
Neumann, D., Barchan, D., Fridkin, M. & Fuchs, S., 1986, In: Proceedings of the National Academy of Sciences of the United States of America. 83, 23, p. 9250-9253 4 p.

Localization of a highly immunogenic region on the acetylcholine receptor α-subunit
Souroujon, M. C., Neumann, D., Pizzighella, S., Safran, A. & Euchs, S., 26 Feb 1986, In: Biochemical and Biophysical Research Communications. 135, 1, p. 82-89 8 p.

Mapping of the cAMP-dependent phosphorylation sites on the acetylcholine receptor.
Souroujon, M. C., Neumann, D., Pizzighella, S., Fridkin, M. & Fuchs, S., Mar 1986, In: EMBO Journal. 5, 3, p. 543-546 4 p.

Mapping of the α-bungarotoxin binding site within the α subunit of the acetylcholine receptor
Neumann, D., Barchan, D., Safran, A., Gershoni, J. M. & Fuchs, S., 1986, In: Proceedings of the National Academy of Sciences of the United States of America. 83, 9, p. 3008-3011 4 p.

1985 | Antibodies to synthetic peptides as probes for the binding site on the α subunit of the acetylcholine receptor
Neumann, D., Gershoni, J. M., Fridkin, M. & Fuchs, S., 1985, In: Proceedings of the National Academy of Sciences of the United States of America. 82, 10, p. 3490-3493 4 p.

1984 | Anti-acetylcholine receptor response achieved by immunization with a synthetic peptide from the receptor sequence
Neumann, D., Fridkin, M. & Fuchs, S., 15 Jun 1984, In: Biochemical and Biophysical Research Communications. 121, 2, p. 673-679 7 p.

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