ד"ר יפתח גפנר

ביה"ס לבריאות הציבור סגל אקדמי בכיר
ד"ר יפתח גפנר
טלפון פנימי: 4726

מחקר

Our reaserch focuses on understanding the impact of exercise training, combined with dietary strategies, on muscle damage and mass, metabolism and performance across a range of populations.

השכלה

Dr. Yftach Gepner is a graduate of Ben-Gurion University's (Beer-Sheva, Israel) in the school of Public Health (2016). His PhD Thesis established the role of combined low-carbohydrate/Mediterranean or low-fat diet, with or without physical activity on various body fat depots (mentor: Prof. Iris Shai).

He then continued his training in the Department of Sport and Exercise at University of Central Florida, to better understand the field of exercise physiology in both applied and basic in nature (mentor: Prof. Jay Hoffman).

His research focuses on understanding the extent, intensity, and type of exercise needed to improve performance and health under a wide range of clinical conditions in a personal manner using cutting-edge technologies, including magnetic resonance imaging (MRI) for assessing muscle damage and body composition, as well as markers of cardiometabolic health.

Dr. Gepner published over 30 peer-review articles that were cited nearly 450 times.

מינויים אקדמיים

  1. Exercise and microbiota contribute to endocrine control of muscle and fat mass after bariatric surgery.
  2. Role of muscle damage as a regulator of muscle mass gain/loss in elderly adults.​
  3. Role of dietary protein intake distribution on muscle protein synthesis, strength and body composition.
  4. Metabolic adaptation following moderate intensity exercise training.
  5. Differences in rate of recovery between young and middle-aged men.

פרסים ומלגות

  1. Hoffman, J. R. et al. The Effect of 2 Weeks of Inactivated Probiotic Bacillus coagulans on Endocrine, Inflammatory, and Performance Responses During Self-Defense Training in Soldiers. J. Strength Cond. Res. 1 (2019). doi:10.1519/JSC.0000000000003265
  2. Gepner, Y., Varanoske, A. N., Boffey, D. & Hoffman, J. R. Benefits of β-hydroxy-β-methylbutyrate supplementation in trained and untrained individuals. Res. Sport. Med. 27, 204–218 (2019).
  3. Gepner, Y. et al. The beneficial effects of Mediterranean diet over low-fat diet may be mediated by decreasing hepatic fat content. J. Hepatol. (2019). doi:10.1016/j.jhep.2019.04.013
  4. Hoffman, J. R., Rathmacher, J. A., Robinson, J., Gepner, Y. & Cohen, H. The Effect of β-Alanine Supplementation on Carnosine and Histidine Content in the Hippocampus of 14-Month Old Rats. Appl. Physiol. Nutr. Metab. apnm-2019-0102 (2019). doi:10.1139/apnm-2019-0102
  5. Boffey, D. et al. The Physiology and Biomechanics of Load Carriage Performance. Mil. Med. 184, e83–e90 (2019).
  6. Hoffman, J. R., Gepner, Y. & Cohen, H. β-Alanine supplementation reduces anxiety and increases neurotrophin expression in both young and older rats. Nutr. Res. 62, 51–63 (2019).
  7. Gepner, Y. et al. Association between circulating inflammatory markers and marksmanship following intense military training. J. R. Army Med. Corps jramc-2018-001084 (2018). doi:10.1136/jramc-2018-001084
  8. Zelicha, H. et al. Changes of renal sinus fat and renal parenchymal fat during an 18-month randomized weight loss trial. Clin. Nutr. 37, 1145–1153 (2018).
  9. Gepner, Y. et al. Effect of Distinct Lifestyle Interventions on Mobilization of Fat Storage Pools. Circulation 137, 1143–1157 (2018).
  10. Hoffman, J. R. et al. Effect of High-Dose, Short-Duration β-Alanine Supplementation on Circulating IL-10 Concentrations During Intense Military Training. J. Strength Cond. Res. 32, 2978–2981 (2018).
  11. Golan, R. et al. Effect of wine on carotid atherosclerosis in type 2 diabetes: a 2-year randomized controlled trial. Eur. J. Clin. Nutr. 72, 871–878 (2018).
  12. Varanoske, A. N. et al. Effects of β-alanine supplementation on physical performance, cognition, endocrine function, and inflammation during a 24 h simulated military operation. Physiol. Rep. 6, e13938 (2018).
  13. Coker, N. A., Wells, A. J. & Gepner, Y. The Effect of Heat Stress on Measures of Running Performance and Heart Rate Responses During A Competitive Season in Male Soccer Players. J. Strength Cond. Res. 1 (2018). doi:10.1519/JSC.0000000000002441
  14. Tene, L. et al. The effect of long-term weight-loss intervention strategies on the dynamics of pancreatic-fat and morphology: An MRI RCT study. Clin. Nutr. ESPEN 24, 82–89 (2018).
  15. Golan, R., Gepner, Y. & Shai, I. Wine and Health–New Evidence. Eur. J. Clin. Nutr. (2018). doi:10.1038/s41430-018-0309-5
  16. Serfaty, D. et al. Abdominal fat sub-depots and energy expenditure: Magnetic resonance imaging study. Clin. Nutr. 36, 804–811 (2017).
  17. Haim, Y. et al. ASK1 (MAP3K5) is transcriptionally upregulated by E2F1 in adipose tissue in obesity, molecularly defining a human dys-metabolic obese phenotype. Mol. Metab. 6, 725–736 (2017).
  18. Gepner, Y. et al. Combined effect of Bacillus coagulans GBI-30, 6086 and HMB supplementation on muscle integrity and cytokine response during intense military training. J. Appl. Physiol. 123, 11–18 (2017).
  19. Gordon, J. A. et al. Comparisons in the Recovery Response From Resistance Exercise Between Young and Middle-Aged Men. J. Strength Cond. Res. 31, 3454–3462 (2017).
  20. Tsaban, G. et al. Dynamics of intrapericardial and extrapericardial fat tissues during long-term, dietary-induced, moderate weight loss. Am. J. Clin. Nutr. 106, 984–995 (2017).
  21. Golan, R. et al. Effects of initiating moderate wine intake on abdominal adipose tissue in adults with type 2 diabetes: a 2-year randomized controlled trial. Public Health Nutr. 20, 549–555 (2017).
  22. Yaskolka Meir, A. et al. Intrahepatic fat, abdominal adipose tissues, and metabolic state: magnetic resonance imaging study. Diabetes. Metab. Res. Rev. 33, e2888 (2017).
  23. Gepner, Y. et al. Intramyocellular triacylglycerol accumulation across weight loss strategies; Sub-study of the CENTRAL trial. PLoS One 12, e0188431 (2017).
  24. Redd, M. J. et al. The effect of HMB ingestion on the IGF-I and IGF binding protein response to high intensity military training. Growth Horm. IGF Res. 32, 55–59 (2017).
  25. Arroyo, E. et al. Tumor necrosis factor-alpha and soluble TNF-alpha receptor responses in young vs. middle-aged males following eccentric exercise. Exp. Gerontol. 100, 28–35 (2017).
  26. Slutsky, N. et al. Decreased adiponectin links elevated adipose tissue autophagy with adipocyte endocrine dysfunction in obesity. Int. J. Obes. 40, 912–920 (2016).
  27. Gepner, Y. et al. Differential Effect of Initiating Moderate Red Wine Consumption on 24-h Blood Pressure by Alcohol Dehydrogenase Genotypes: Randomized Trial in Type 2 Diabetes. Am. J. Hypertens. 29, 476–483 (2016).
  28. Gepner, Y. et al. Higher visceral adiposity is associated with an enhanced early thermogenic response to carbohydrate-rich food. Clin. Nutr. 35, 422–427 (2016).
  29. Yaskolka Meir, A. et al. Intermuscular adipose tissue and thigh muscle area dynamics during an 18-month randomized weight loss trial. J. Appl. Physiol. 121, 518–527 (2016).
  30. Hoffman, J. R. et al. β-Hydroxy-β-methylbutyrate attenuates cytokine response during sustained military training. Nutr. Res. 36, 553–563 (2016).
  31. Henkin, Y., Kovsan, J., Gepner, Y. & Shai, I. Diets and morbid tissues – history counts, present counts. Br. J. Nutr. 113, S11–S18 (2015).
  32. Gepner, Y. et al. Effects of Initiating Moderate Alcohol Intake on Cardiometabolic Risk in Adults With Type 2 Diabetes. Ann. Intern. Med. 163, 569 (2015).
  33. Haim, Y. et al. Elevated autophagy gene expression in adipose tissue of obese humans: A potential non-cell-cycle-dependent function of E2F1. Autophagy 11, 2074–2088 (2015).
  34. Golan, R. et al. Abdominal Superficial Subcutaneous Fat: A putative distinct protective fat subdepot in type 2 diabetes. Diabetes Care 35, 640–647 (2012).
  35. Bluher, M. et al. Two Patterns of Adipokine and Other Biomarker Dynamics in a Long-Term Weight Loss Intervention. Diabetes Care 35, 342–349 (2012).
  36. Canfi, A. et al. Effect of changes in the intake of weight of specific food groups on successful body weight loss during a multi-dietary strategy intervention trial. J. Am. Coll. Nutr. 30, 491–501 (2011).
  37. Leichtle, A. B. et al. Effects of a 2-y dietary weight-loss intervention on cholesterol metabolism in moderately obese men. Am. J. Clin. Nutr. 94, 1189–1195 (2011).

 

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