Prof. Avi A Weinbroum, M.D.
Director, Post-Anestehsia Care
Director, Pre-Clinical Research Laboratory
Department of Anesthesiology, Emergency Medicine, Intensive Care & Pain Management
Tel AvivSourasky Medical Center
Sackler Faculty of Medicine
Tel Aviv University, Tel Aviv, Israel
Areas of Interests:
Academic and other positions
Professor, the Sackler Faculty of Medicine, Tel Aviv University
Past Chair, Department of Anesthesiology, the Sackler Faculty of Medicine
Member of the Tel Aviv University Senate
Research areas
I have long been studying the effects of ischemia-reperfusion isolated perfused organs. I have evidenced the pivotal role of oxygen free radicals in promoting such injuries, and provided therapeutic pathways, using on-shelf compounds, aiming at preventing or attenuating isolated organ or systemic repercussion of ischemia-reperfusion event. My group has recently established evidence as to the role of these agents in propelling cytokines following chest blunt trauma.
ventions. Indeed, gas insufflated into the peritoneum is a temporary event, which, however, may detriment organs, such as the kidney. Modes of moderating the insufflation-associated damage or its prevention are currently under investigation.
Pain constitutes a physiological factor accompanying trauma, damage to the tissue or following surgical interventions. While past theories suggested that opioids are the best compounds to be administered in order to attenuate and later eliminate such pain, we are now aware of the fact that such administration may rather generate resistance to morphine or even worsen the phenomenon of pain. I have been among the first to demonstrate the beneficial role of ketamine, a long-standing, partly clinically abandoned, anesthetic, that when used in ultra-low doses would minimize resistance to postoperative morphine, block hyperalgesia that occurs after remifentanil, and also reduces the dose of morphine that is consumed in order to control postoperative pain.
List of publications (2008-2012)
Szold A, Weinbroum AA.
Carbon dioxide pneumoperitoneum-related liver injury is pressure dependent: A study in an isolated-perfused organ model.
Surg Endosc 2008; 22:365-71.
Ben-Abraham R, Flaishon R, Sotman A, Ekstein P, Ezri T, Ogorek D, Weinbroum AA.
CobraPLA™ Insertion by anesthetists and non-anesthetists wearing unconventional protective gear: A prospective study in humans.
Med Sci Monit 2008; 14:PI13-18.
Kollender Y, Bickels J, Stocki D, Maruoani N, Chazan S, Nirkin A, Meller I, Weinbroum AA.
Subanaesthetic ketamine spares postoperative morphine and controls pain better than standard morphine does alone in orthopaedic-oncological patients.
Eur J Cancer 2008; 44:954-62.
Nesher N, Marouani N, Serovian I, Ekstein MP, Chazan S, Weinbroum AA.
Ketamine spares morphine consumption after transthoracic lung and heart surgery without adverse hemodynamic effects.
Pharmacol Res 2008; 58:38-44.
Khoury W, Jakowlev K, Fein A, Orenstein H, Nakache R, Weinbroum AA.
Renal apoptosis following carbon dioxide pneumoperitoneum in a rat model.
J Urol 2008; 180:1554-8.
Chazan S, Ekstein MP, Marouani N, Weinbroum AA.
Ketamine for acute and subacute pain in opioid-tolerant patients.
J Opioid Manag 2008; 4:173-80.
Nesher N, Ekstein MP, Paz Y, Marouani N, Chazan S, Weinbroum AA.
Morphine with adjuvant ketamine vs. higher doses of morphine alone for immediate post-thoracotomy analgesia.
Chest 2008 136:245-52.
Pevni D, Frolkis I, Schwartz D, Schwartz I, Chernichovski T, Kramer A, Ben-Gal Y, Uretzky G, Shapira I, Weinbroum A.
New evidence for the role of TNF-alpha in liver ischaemic/reperfusion injury.
Eur J Clin Invest 2008; 38:649-55.
Ben-Abraham R, Flaishon R, Sotman A, Ezri T, Weissenberg M, Weinbroum AA. Cuffed oropharyngeal airway (COPA) placement is delayed by wearing antichemical protective gear.
Emerg Med J 2008; 25:847-50.
Ekstein M, Gavish D, Ezri T, Weinbroum AA.
Monitored Anaesthesia Care in the Elderly: Guidelines and Recommendations.
Drugs Aging 2008; 25:477-500.
Oifa S, Sydoruk T, White I, Ekstein MP, Marouani N, Chazan S, Skornick Y, Weinbroum AA.
Effects of intravenous patient-controlled analgesia with buprenorphine and morphine alone and in combination during the first 12 postoperative hours: a randomized, double-blind, four-arm trial in adults undergoing abdominal surgery.
Clin Ther 2009; 31:527-41.
Avital S, Itah R, Szomstein S, Rosenthal R, Inbar R, Sckornik Y, Weinbroum A.
Correlation of CO(2) pneumoperitoneal pressures between rodents and humans.
Surg Endosc 2009; 23:50-4.
Weinbroum AA.
Mannitol prevents acute lung injury after pancreas ischemia-reperfusion: a dose-response, ex vivo study.
Lung 2009; 187:215-24.
Vater Y, Dembo G, Klein Y, Martay K, Khoury W, Vitin A, Ogorek D, Weinbroum AA.
Perioperative care in alpers syndrome carrier: Case presentation and literature survey.
Am J Case Rep 2009; 10:155-160.
Weinbroum AA.
Methylene blue attenuates pancreas ischemia-reperfusion (IR)-induced lung injury: a dose response study in a rat model.
J Gastrointest Surg 2009; 13:1683-91.
Khoury W, Namnesnikov M, Fedorov D, Abu-Ghazala S, Weinbroum AA.
Mannitol attenuates kidney damage induced by xanthine oxidase-associated pancreas ischemia-reperfusion.
J Surg Res 2010; 160:163-8.
Khoury W, Szold O, Soffer D, Kariv Y, Wasserlauf R, Klausner JM, Ogorek D, Weinbroum AA.
Prophylactic fluconazole does not improve outcome in patients with purulent and fecal peritonitis due to lower gastrointestinal perforation.
Am Surg 2010; 76:197-202.
Chazan S, Buda I, Nesher N, Paz J, Weinbroum AA.
Low-dose ketamine via intravenous patient-controlled analgesia device after various transthoracic procedures improves analgesia and patient and family satisfaction.
Pain Manag Nurs 2010; 11:169-76.
Biderman P, Weinbroum AA, Rafaeli Y, Raz E, Porat E, Wiesel O, Szold O.
Retrosternal percutaneous tracheostomy: an approach for predictably impossible classic tracheostomy.
Crit Care Res Pract 2010; 2010:397270.
Aptekman B, Tarashansky M, Sotman A, Khuri W, Ben-Abraham R, Dolkart O, Weinbroum AA.
Effects of methylene blue and volatile anesthetics on survival in a murine hemorrhage resuscitation model.
J Trauma 2010; 69:1433-40; discussion 1440-1.
Telpner R, Ben-Abraham R, Klein Y, Nakache R, Khoury W, Weinbroum AA.
Intrasplenic Preconditioning: A Model for the Study of Xenostimuli Accommodation.
J Surg Res 2011;168:135-42.
Ekstein MP, Weinbroum AA.
Immediate Postoperative Pain in Orthopedic Patients Is More Intense and Requires More Analgesia than in Post-Laparotomy Patients.
Pain Med 2010; 12:308-13.
Bronstein I, White I, Ekstein MP, Brill S, Chazan S, Ogorek D, Ben-Abraham R, Amar E, Weinbroum AA.
Higher postoperative pain and increased morphine consumption follow pre- rather than post-incisional single dose epidural morphine.
Minerva Anestesiol 2011;77:408-17.
Rakhman E, Shmain D, White I, Ekstein MP, Kollender Y, Chazan S, Dadia S, Bickels J, Amar E, Weinbroum AA.
Repeated and escalating preoperative subanesthetic doses of ketamine for postoperative pain control in patients undergoing tumor resection: a randomized, placebo-controlled, double-blind trial.
Clin Ther 2011; 33:863-73.
Khoury W, Weinbroum AA.
Oxidants as important determinants of renal apoptosis during pneumoperitoneum: a study in an isolated perfused rat kidney model.
Surg Endosc 2012; 26:1417–24.
Weinbroum AA.
Non-opioid IV adjuvants in the perioperative period: Pharmacological and clinical aspects of ketamine and gabapentinoids.
Pharmacol Res 2012; 65:411-29.
Dichtwald S, Weinbroum AA, Sorkine P, Ekstein MP, Dahan E.
Metformin-associated lactic acidosis following acute kidney injury. Efficacious treatment with continuousrenal replacement therapy
Diabet Med 2012; 29:245–50.
Karplus G, Szold A, Serour F, Weinbroum AA.
The hepatorenal reflex contributes to the induction of oliguria during pneumoperitoneum in the rat.
Surg Endosc 2012;26:2477-83.
White I, Ghinea R, Avital S, Chazan S, Dolkart O, Weinbroum AA.
Morphine at "sub-analgesic" background infusion rate plus low-dose PCA bolus control pain better and is as safe as twice a bolus-only PCA regimen: a randomized, double blind study.
Pharmacol Res 2012; 66:185-91.
Vater Y, Dembo G, Martay K, Vitin A, Amar E, Weinbroum AA.
Ascites characterizes perioperative clinical indices better than preoperative body mass index. A study in orthotopic liver transplant candidates.
Minerva Anestesiol 2012; 78:910-9.
Khoury W, Kin C, Yehuda AB, Weinbroum AA.
Assessment of the clinical usefulness of imaging modalities in identifying postoperative upper gastrointestinal tract leaks requiring reoperation.
Surg Laparosc Endosc Percutan Tech. 2012; 22:328-32.
Dolkart O, Khoury W, Avital S, Flaishon R, Weinbroum AA.
Changes in end-tidal carbon dioxide due to gastric perforation during pneumoperitoneum in the rat.
Isr Med Assoc J 2012; 14:747-51.
Duek SD, Kluger Y, Grunner S, Weinbroum AA, Khoury W.
Transanal endoscopic microsurgery for the resection of submucosal and retrorectal tumors.
Surg Laparosc Endosc Percutan Tech 2013; 23:66-8.
Grants (2008-2012)
Clinical study on the postoperative antinociceptive efficacy of buprenorphine and morphine in large bowel surgery patients (Drug Manufacturer)
Trauma and Pre-Hospital Care Grant (2010, IDF)
Trauma and Pre-Hospital Care and Treatment Grant (2011, IDF)
Trauma and Pre-Hospital Care and Treatment in humans, Grant (2012, IDF).
