Prof. Oded Rechavi’s mission is to challenge fundamental long-held scientific dogmas. He found an exception to the original “Cell Theory”, provided the first direct evidence that an acquired trait can be inherited, elucidated an alternative transgenerational inheritance mechanism (that depends on inherited small RNA molecules, not DNA molecules), discovered a mechanism that allows nematodes’ brains to control the behavior of their progeny, discovered a neuronal circuit-level mechanism that explains economic irrationality, and demonstrated that parasites can be genetically engineered to deliver drugs to the nervous system. Recently, Prof. Rechavi utilized genome sequencing to “piece together” fragments of the Dead Sea Scrolls. Prof. Rechavi is an ERC Fellow, and was awarded many prestigious prizes, such as the Schmidt Science Polymath award, the Kadar award, Blavatnik award, the Krill Wolf award, the Alon, and F.I.R.S.T (Bikura) Prizes, and the Gross Lipper Fellowship. Prof. Rechavi was selected as one of the “10 Most Creative People in Israel Under 40”, and one of the “40 Most Promising People in Israel Under 40”.
פרופ' עודד רכבי
In our lab we challenge basic dogmas regarding inheritance and evolution, using simple powerful genetic model organisms. In particular, using nematodes, we have shown that exposure to different challenges triggers the synthesis of heritable small RNAs which regulate genes in the progeny, resulting in phenotypic changes several generations down the road. In addition to studying epigenetic inheritance, we are developing useful parasites, investigating the neuronal basis of rational decision-making, and try to do as many crazy experiments as possible.
We focus our studies mostly, but not exclusively, on C.elegans nematodes, wonderful creatures that we find irresistible. C.elegans has a super-short generation time of just 3 days, and its nervous system is composed of just 302 neurons (and the entire “connectome” is mapped). These properties, combined with awesome genetic tools and unparalleled ease of cultivation, make the worm the ideal model organism for studying memory, and in particular heritable memory. Nevertheless, we are aware that other organisms have feelings too, and therefore try to make our studies as relevant as possible, so no one is offended. We currently study also toxoplasma parasites, and planaria flatworms, but there are often other weird animals running around the lab.
Recently, as part of a totally different crazy project, we pieced the Dead Sea Scrolls “puzzle” by sequencing ancient DNA extracted from the animal skins on which the scrolls were written.
L.Houri-Ze’evi*, O.Antonova, O.Rechavi. Three Rules Explain Transgenerational Small RNA Inheritance in C.elegans. Cell, 2020. https://doi.org/10.1016/j.cell.2020.07.022
S.Anava, M.Neuhof, H.Gingold, O.Sagy, A.Munters, E.M.Svensson, E.Afshinnekoo, D.Danko, J.Foox, P.Shor, B.Riestra, D.Huchon, C.E. Mason, N.Mizrahi, M.Jakobsson, O.Rechavi. Illuminating Genetic Mysteries of the Dead Sea Scrolls. Cell, 2020. (Selected for the cover.) https://doi.org/10.1016/j.cell.2020.04.046
D.Cohen*, G.Teichman*, M.Volovich, Y.Zeevi, L.Elbaum, A.Madar, K.Louie, D.J.Levy, O.Rechavi. Bounded rationality in C. elegans is explained by circuit-specific normalization in chemosensory pathways. Nature Communications, 2019. https://doi.org/10.1038/s41467-019-11715-7
I.Lev*, I.A.Toker*, Y.Mor*, A.Nitzan, G.Weintraub, O. antonova, O.Bhonkar, I.Ben-Shushan, U.Seroussi, J.M.Claycomb, S.Anava, H.Gingold, R.Zaidel-Bar, O.Rechavi. Germ Granules Govern Small RNA Inheritance. Current Biology. https://doi.org/10.1016/j.cub.2019.07.054
R.Posner*, I.A.Toker*, O.Antonova, E.Star, S.Anava, E.Azmon, M.Hendricks, S.Bracha, H.Gingold, O.Rechavi. Neuronal Small RNAs Control Behavior Transgenerationally. Cell, Vol. 177, Issue 7, P.1814-1826, 2019, https://doi.org/10.1016/j.cell.2019.04.029
I.Lev, R.Bril, Y.Liu, L.I.Cere, O.Rechavi. Inter-generational Consequences for Growing C. elegans in Liquid. Philosophical Transactions of The Royal Society B. Vol.374, Issue 1770, 2019. https://doi.org/10.1098/rstb.2018.0125
I.Lev, H.Gingold, O.Rechavi. H3K9me3 is Required for Inheritance of Small RNAs that Target a Unique Subset of Newly Evolved Genes. eLife 2019;8:e40448, 2019. doi: https://doi.org/10.7554/eLife.40448.001
A.Hakim, Y.Mor, I.A.Toker, A. Levine, M.Neuhof, Y.Markovitz, O.Rechavi. WorMachine: Machine Learning-Based Phenotypic Analysis Tool for Worms. BMC Biology, 16:8, 2018. https://doi.org/10.1186/s12915-017-0477-0
O.Rechavi, I.Lev. Principles of Transgenerational Small RNA Inheritance in C. elegans. Current Biology, Vol.27, Issue 14, 2017 (pp. R720-R730). doi: http://dx.doi.org/10.1016/j.cub.2017.05.043
I.Lev, U.Seroussi, H.Gingold, R.Bril, S.Anava, O.Rechavi. MET-2-Dependent H3K9 Methylation Suppresses Transgenerational Small RNA Inheritance. Current Biology, Vol.27, 2017 (pp.1138-1147). https://doi.org/10.1016/j.cub.2017.03.008
L.Houri-Ze’evi, O.Rechavi. A Matter of Time: Small RNAs Regulate the Duration of Epigenetic Inheritance. Trends in Genetics, Vol.33, 2017 (pp.46-57). https://doi.org/10.1016/j.tig.2016.11.001
L.Houri-Ze’evi, Y.Korem, H.Sheftel, L.Faigenbloom, I.Toker, Y.Dagan, L.Awad, L.Dagani, U.Alon, O.Rechavi. A Tunable Mechanism Determines the Duration of the Transgenerational Small RNA Inheritance in C. elegans. Cell, Vol.165, 2016 (pp.88–99). https://doi.org/10.1016/j.cell.2016.02.057
D.Sagi, R.Rak, H.Gingold, I.Adir, G.Maayan, O.Dahan, I.Pilpel, O.Rechavi, Tissue-and Time-Specific Expression of Otherwise Identical tRNA Genes. PLoS Genetics, 2016, https://doi.org/10.1371/journal.pgen.1006264
O.Rechavi, L.Houri-Ze'evi, S.Anava, W.S.Sho Goh, S.Y.Kerk, G.J.Hannon, O.Hobert. Starvation-induced transgenerational inheritance of small RNAs in C.elegans. Cell, Vol.158, 2014 (pp.277-287). https://doi.org/10.1016/j.cell.2014.06.020 Corresponding author.
O.Rechavi, G.Minevich, O.Hobert. Transgenerational Inheritance of an Acquired Small RNA-Based Antiviral Response in C.Elegans. Cell, Vol.147, 2011 (pp.1248–1256). https://doi.org/10.1016/j.cell.2011.10.042
O.Rechavi, M.Kalman, Y.Fang, H.Vernitsky, J.Jacob-Hirsch, L.J.Foster, Y.Kloog, I.Goldstein. Trans-SILAC: sorting out the non-cell-autonomous proteome. Nature Methods, Vol.7, 2010 (pp.923-927). https://doi.org/10.1038/nmeth.1513
O.Rechavi, Y. Erlich, H.Amram, L.Flomenblit, F.V.Karginov, I.Goldstein, G.J.Hannon, Y.Kloog. Cell contact-dependent acquisition of cellular and viral nonautonomously encoded small RNAs. Genes & Development, Vol.23, 2009 (pp.1971-1979). https://doi.org/10.1101/gad.1789609