פרופ' ניר גלעדי

סגל אקדמי קליני בנוירולוגיה
מופקד על קתדרה בדיקאנט ומנהל הפקולטה לרפואה
סגן דקאן בדיקאנט ומנהל הפקולטה לרפואה
נוירולוגיה סגל אקדמי קליני
פרופ' ניר גלעדי
פקס: 03-6974153

Biographical Skatch

NAME:

Nir Giladi M.D.

 

 

POSITION TITLE:

Professor of Neurology

Chairman of the Department of Neurology

Tel Aviv Medical Center

Incumbent of the Sieratzki Chair in Neurology

Director of the Department of Neurology

Sackler School of Medicine, Sagol School of Neuroscience Tel-Aviv University, Israel

 

eRA Commons user name: EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing.  Include postdoctoral training.)

 

INSTITUTION AND LOCATION: Beer Sheba University, Israel

 

DEGREE: M.D.

 

YEAR(s): 1977-1983

 

FIELD OF STUDY: Medicine

 

We would like to investigate bio-markers for Parkinson's disease based on linkage of huge datasets.  I have the expertise, leadership and motivation necessary to successfully carry out the proposed work. In the last years I managed, overlooked and carried out numerous epidemiological database studies, with expertise in all medical, clinical and applicative aspects.  I have been studying the epidemiology of Parkinson's disease in cooperation with Dr. Chava Peretz for over 20 years. This research is based on prior investigations and knowledge (see publications), and on our clinical work at the Movement Disorders Unit, the Tel Aviv Medical Center. We have been using datasets from multiple data sources of Israel's largest HMO – Maccabi - a pharmacy dataset, disease registries and administrative data.

 

Position and Honors

Clinical Positions:

1974-1977

1983-1984

1985-1989

1991-1992

1993-1996

 

1996- 2007

2007-

2014-              

Zahal Military Medic

Internship studies in Neurology in Haemek Hospital, Afula, Israel                               

Resident in Carmel Medical Center, Haifa, Israel               

Resident in Carmel Medical Center, Haifa, Israel               

Director of Parkinson's and Movement Disorders Clinic at the Neurology Dpt. of Carmel Medical                Center, Technion School of Medicine, Haifa, Israel            

Director of Movement Disorders Unit, Dpt. of Neurology at Tel Aviv Medical Center, Tel-Aviv, Israel

Chairman, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel

Director of the department of Neurology Sackler School of medicine, Tel Aviv University

 

 

 

 

 

 

Academic Positions:

1991-1996

1994

1997

1998

2000-2007

2002

2007

2011          

Teaching Neurology at the Technion School of Medicine, Haifa

Lecturer, Technion School of Medicine

Teaching Neurology at Tel-Aviv University School of Medicine 

Lecturer, Sackler School of Medicine, Tel Aviv University

Teaching Neurology at Tel-Aviv University Post-Graduate School of Physical Therapy

Senior Lecturer at the Tel Aviv University School of Medicine
  Associate Professor

Full Professor

2014-2015  A member of the Clinical teaching committee at Tel Aviv University School of Medicine

 

 

Awards and other professional activities:

1993

 

2001

 

2004

2006

2007

2009-2011

2011-2013

2012

2012

2013- 2017

 

The Israeli Neurological Society, Weisbord award for young researchers of the extrapyramidal system

The Israeli Ministry of Health The General Director’s award for excellence in medicine for the Movement Disorders Unit

The Tel Aviv University, Sackler Faculty of Medicine : Excellence in teaching award                                                                                                                                                                                                                                                                     

Tel Aviv Sourasky Medical Center: Excellence for Medical Care Award of the General Director

Tel Aviv University School of Allied  Health : Excellence in teaching award

Treasurer elect - The International Movement Disorders Society

Treasurer -The International Movement Disorders Society

Member of the Israeli Supreme Health Basket Committee

Chairman of the Sieratzki Neurological Research Cathedral, Tel Aviv University

Chairman Scientific Advisory Board Israeli Parkinson Association 

 

 

 

 

Fellowships and visiting professorship:

1989-1991

1996

2001

2006

2010

2012

Columbia University, Neurological Institute, Movement Disorders

Columbia University, Neurological Institute, Movement Disorders

Sabbatical - Oxford University, The laboratory for Functional Neurosurgery, Oxford, UK

Sabbatical – Visiting Professor - Radboud University School of Medicine Nijmegen, Netherlands

Visiting Professor – Yangzhou University, School of Medicine, Yangzhou, China

Visiting Professor – Oregon Health & Science University, Portland, USA

 

Selected Peer Review Responsibilities:

Member of the Editorial Board                                          

Journal of Neural Transmission – since 2007                                                                 

Movement Disorders Journal –2004- 2010

Parkinsonism & Related Disorders 2005-2008

Journal Parkinson's disease – since 2011

Reviewer

Neurology, Oxford University Press, Parkinsonism & Related Disorders,

Brain, Journal of Neurology, Gait & Posture, Experimental Brain Research,

J Neural Transm, JNNP, Movement Disorders Journal, Lancet Neurology,

Annals of Neurology , Cerebral Cortex       

Associated Editor

Movement Disorders Special Suppl., Freezing of Gait 2008, 2013

Journal Neural Transmission since 2008

 

 

 

Selected Publications (from more than 200 peer reviewed publications

Parkinson

 

1. Thaler A., Mirelman A., Gurevich T., Simon E., Orr-Urtreger A., Marder K.S., Bressman S.,   Giladi N.

Lower cognitive performance in healthy G2019S LRRK2 mutation carriers

Neurology Sep 4;79(10):1027-1032.

 

2. Van Nuenen BF, Helmich RC, Ferraye M, Thaler A, Hendler T, Orr-Urtreger A, Mirelman A, Bressman S, Marder KS, Giladi N, van de Warrenburg BP, Bloem BR, Toni I; on behalf of the LRRK2 Ashkenazi Jewish Consortiu.

Cerebral pathological and compensatory mechanisms in the premotor phase of leucine-rich repeat kinase 2 parkinsonism.

Brain. 2012 Dec;135(Pt 12):3687-3698.

 

3. Rosenberg Katz K., Herman T., Jacob Y., Giladi N., Hendler T., Hausdorff J.M.

Gray matter atrophy distinguishes between Parkinson Disease motor subtypes

Neurology, 2013;80:1–9.

 

4. Gan-Or Z, Ozelius LJ, Bar-Shira A, Saunders-Pullman R, Mirelman A, Kornreich R, Gana-  Weisz M, Raymond D, Rozenkrantz L, Deik A, Gurevich T, Gross SJ, Schreiber-Agus N,  Giladi N, Bressman SB, Orr-Urtreger A.

The p.L302P mutation in the lysosomal enzyme gene SMPD1 is a risk factor for Parkinsons' disease.

Neurology. 2013 Apr 23;80(17):1606-10.

 

5. Plotnik M., Shama S., Brozgol M., Dorfman M., Gazit E., Giladi N., Hausdorff J.M.

A motor learning based intervention to ameliorate freezing of gait in subjects with Parkinson's disease

J Neurol. 2014 Apr 23

 

 

Genetics:

6. A. Orr-Utreger, C. Shifrin, U. Rozovsky, S. Rosner, D. Berkovich, T Gurevich, H Yagev More, A. Bar Shira, N. Giladi.
The LRRK2 G2019S mutation in Ashkenazi Jews with Parkinsons disease is there a gender effect?
Neurology 69(16):1595-1602; 2007.
IF= 8.017. Rank in category: Clinical Neurology= 4/185

 

7. E Sidransky, MA Nalls, JO Aasly, J. Aharon-Peretz , G. Annesi, ER Barbosa, A. Bar-Shira, D.Berg, J. Bras, A. Brice, CM.Chen, LN. Clark, C. Condroyer, EV. De Marco, A. Dürr, MJ. Eblan, S. Fahn, MJ. Farrer, HC. Fung, Z. Gan-Or, T. Gasser,  R. Gershoni-Baruch, N. Giladi, A. Griffith, T. Gurevich, C. Januario, P. Kropp, AE. Lang, GJ. Lee-Chen, S. Lesage, K. Marder, IF. Mata, A. Mirelman, J. Mitsui, I Mizuta, G. Nicoletti, C. Oliveira, R. Ottman, A. Orr-Urtreger, LV. Pereira, A. Quattrone, E. Rogaeva, A. Rolfs, H. Rosenbaum, R. Rozenberg, A. Samii, T. Samaddar, C. Schulte, M. Sharma, A. Singleton, M. Spitz, EK. Tan, N. Tayebi, T. Toda, AR. Troiano, S. Tsuji, M. Wittstock, TG. Wolfsberg, YR. Wu, CP. Zabetian, Y. Zhao, SG. Ziegler.
Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease.
N Engl J Med; 361(17):1651-61; 2009.
IF=53.486. Rank in category: Medicine ,General & Internal=1/153

 

8. Mirelman A., Gurevich T., Giladi N., Bar-Shira A., Orr-Urtreger A., Hausdorff JM.

Gait Alterations in Healthy Carriers of the LRRK2 G2019S Mutation.

Ann Neurol. 2011 Jan;69(1):193-7.

IF= 10.746. Rank in category: Clinical Neurology =2/185, Neurosciences = 9/239

 

9. Kedmi M., Bar-Shira A., Gurevich T., Giladi N., Orr-Urtreger A.

Decreased expression of B cell related genes in leukocytes of women with Parkinson's disease.

Molecular Neurodegeneration 2011 Sep 23;6:66.

 

10. Thaler A, Mirelman A, Gurevich T, Simon E, Orr-Urtreger A, Marder K, Bressman S, Giladi N; LRRK2 Ashkenazi Jewish Consortium

Lower cognitive performance in healthy G2019S LRRK2 mutation carriers.

Neurology 2012 Sep 4;79(10):1027-32

 

11. Van Nuenen BF, Helmich RC, Ferraye M, Thaler A, Hendler T, Orr-Urtreger A, Mirelman A, Bressman S, Marder KS, Giladi N, van de Warrenburg BP, Bloem BR, Toni I; on behalf of the LRRK2 Ashkenazi Jewish Consortium.

Cerebral pathological and compensatory mechanisms in the premotor phase of leucine-rich repeat kinase 2 parkinsonism.

Brain. 2012 Dec;135(Pt 12):3687-3698.

 

12. Kenny EE, Pe'er I, Karban A, Ozelius L, Mitchell AA, Ng SM, Erazo M, Ostrer H, Abraham C, Abreu MT, Atzmon G, Barzilai N, Brant SR, Bressman S, Burns ER, Chowers Y, Clark LN, Darvasi A, Doheny D, Duerr RH, Eliakim R, Giladi N, Gregersen PK, Hakonarson H, Jones MR, Marder K, McGovern DP, Mulle J, Orr-Urtreger A, Proctor DD, Pulver A, Rotter JI, Silverberg MS, Ullman T, Warren ST, Waterman M, Zhang W, Bergman A, Mayer L, Katz S, Desnick RJ, Cho JH, Peter I.

A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.

PLoS Genet. 2012;8(3):e1002559.

 

13. Thaler A, Mirelman A, Helmich RC, van Nuenen BF, Rosenberg-Katz K, Gurevich T, Orr-Urtreger A, Marder K, Bressman S, Bloem BR, Giladi N, Hendler T; the LRRK2 Ashkenazi Jewish consortium.

Neural correlates of executive functions in healthy G2019S LRRK2 mutation carriers.

Cortex. 2013 Jan 7. pii: S0010-9452(12)00374-7.

 

 

Gait:

14. N. Giladi, J. Tal, T. Azulay, O. Rascol, DJ. Brooks, E. Melamed, W. Oertel, WH. Poewe, F. Stocchi, E. Tolosa
Validation of the Freezing of Gait Questionnaire in patients with Parkinson’s disease.
Mov Disord 24(5) :655-61;2009.
IF= 4.480. Rank in category: Clinical Neurology= 27/185

 

15. Weiss A., Sharifi S., Plotnik M., Van Vugt J.P.P., Giladi N. and Hausdorff J.M.

Toward Automated, At-Home Assessment of Mobility among Patients with Parkinson’s Disease, Using a Body-Worn Accelerometer.

Journal of Neurorehabilitation and Neural Repair, 2011 Nov-Dec;25(9):810-8.

IF=3.772 Rank in category: Rehabilitation= 1/44, Clinical Neurology=37/185

 

16. A. Mirelman, T. Herman, M. Brozgol, M. Dorfman, E. Sprecher, A. Schweiger, N. Giladi, JM. Hausdorff.
Executive function and falls in older adults: new findings from a five-year prospective study link fall risk to cognition.
PLoS One. 2012;7(6):e40297

 

17. Yogev-Seligmann G, Hausdorff JM, Giladi N.

Do we always prioritize balance when walking? Towards an integrated model of task prioritization.

Mov Disord. 2012 May;27(6):765-70

 

 

Epidemiology:

18. Inzelberg R., Rabey JM., Melamed E., Djaldetti R., Reches A., Badarny S., Hassin-Baer S., Cohen O., Trau H., Aharon-Peretz J., Milo R., Schwartz M., Huberman M., Gilead L., Barchana M., Liphshiz I., Fitzer-Attas C., Giladi N.

High prevalence of malignant melanoma in Israeli patients with Parkinson’s disease.

J Neural Transm. 2011 Aug;118(8):1199-207.

IF= 2.597. Rank in category: Clinical Neurology =73/185, Neurosciences = 132/239

 

19. Chillag-Talmor O., Giladi N., Linn S., Gurevich T., El-Ad B., Silverman B., Friedman N., Peretz C.

Use of a Refined Drug Tracer Algorithm to Estimate Prevalence and Incidence of Parkinson’s Disease in a Large Israeli Population.

Journal of Parkinson’s Disease. 2011 May; 1(1): 35–47.

 

20. Chillag-Talmor O, Giladi N, Linn S, Gurevich T, El-Ad B, Silverman B, Friedman N, Peretz C.

Estimation of Parkinson's disease survival in Israeli men and women, using health maintenance organization pharmacy data in a unique approach.

J Neurol. 2013 Jan;260(1):62-70

 

 

 

Recent cmpetitive grants:

 

 

Year

Name of Project

Source of grant

2009-2011

 

Decoding the genetic background of Parkinson’s Disease (Co- Investigator)

 

The Israel Science Foundation(ISF)

2009-2013

 

FMRI of first degree relatives of patients with PD carrying the LRRK2 G2019S mutation (PI)

 

Radboud University, Nijmegen, Netherland

2009-2012

 

Mutations in the LRRK2 gene among Ashkenazi Jews, consortium with Columbia University and Beth Israel Medical Center in New York (Co-PI)

 

Michael J Fox Foundation, USA

2010-2012

 

White matter changes in patients with Parkinson's disease (Co- PI)

 

Michael J Fox Foundation, USA

2010-2012

 

Ambulatory  monitoring of near falls: A novel measure of fall risk (Co-Investigator)

 

National Institute of Health, USA

2012-2013

 

A prospective study to determine the relationships between cognitive function, gait and fall risk.
 

Israel Chief Scientist

2010-2012

 

DAT SPECT of PD patients and their first degree relatives (PI)

 

Michael J Fox Foundation, USA

2011-2015

 

The Parkinson’s Disease, Ashkenazi Jews and LRRK2

Consortium – a longitudinal extension (Co-PI)

 

Michael J Fox Foundation, USA

2011-2013

 

fMRI of First degree relatives of  LRRK2 positive PD patients (PI)

 

Michael J Fox Foundation, USA

2011-2014

 

Wireless Insole for Independent and Safe Elderly Living (Co-PI)

 

European Union 7th Framework Program

2011-2015

 

Virtual reality-Treadmill combined Intervention for enhancing Mobility and reducing falls in the Elderly (Co-PI)

 

European Union 7th Framework Program

2011-2014

 

Closed-loop system for personalized and at-home rehabilitation of people with Parkinson's Disease, CUPID (Co- PI)

 

European Union 7th Framework Program

2013-2018

 

NPF Center of Excellence, Support Care and Outreach (PI)

 

National Parkinson Foundation, USA

2013

 

PPMI – Biological Markers in Asymptomatic carriers of G2019s mutations in the LRRK2 gene (PI)

 

Michael J Fox Foundation, USA

 

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