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Boettcher, M., Fredebohm J., Gholami A.M., Hachmo, Y., Dotan, I., Canaani, D. Hoheisel, J., (2010) Decoding pooled RNAi screens by means of barcode tiling arrays. BMC Genomics 11 :7 Canaani, D. (2009) Methodological approaches in application of synthetic lethality screening towards anticancer therapy. Br. J. Cancer 100, 1213-1218. |
Canaani D. (2014) Application of the Concept Synthetic Lethality Toward Anticancer Therapy: A Promise Fulfilled? Cancer Letters 352 (1) 59-65.
Dotan, I., Kopatz, I., Naiman, T., Perelman, B., Dafni, N., and Canaani, D. (1995) Establishment of an autocatalytic conditional mammalian system for expression of stringently regulated genes. Nucleic Acids Res. 23 : 307-309.
Dotan, I., Ziv, E., Dafni, N., Beckman, J.S., McCann, R.D., Glover, C.V.C., and Canaani, D. (2001) Functional conservation between the human, nematode and yeast CK2 cell cycle genes. Biochem. Biophys. Res. Commun. 288 : 603-609.
Einav, Y., Shistik, Y., Shenfeld, M., Simons, A.H., Melton, D.W., and Canaani, D. (2003) Replication and episomal maintenance of EBV-based vectors in mouse embryo fibroblasts enable synthetic lethality screens. Mol. Cancer Ther., 2, 1121-1128.
Einav, Y., Agami, R., and Canaani, D. (2005) shRNA-mediated RNA interference as a tool for genetic synthetic lethality screening in mouse embryo fibroblasts. FEBS Lett. 579, 199-2002.
Kopatz, I., Naiman, T., Eli, D., and Canaani, D. (1990) The nucleotide sequence of the mouse cDNA encoding the beta subunit of casein kinase II. Nucleic Acids Res. 18 : 3639.
Liang Chengyu, Feng Pinghui, Ku Bonsu, Dotan Iris, Canaani Dan, Oh Byung-Ha, and Jung U. Jae (2006) Autophagic and tumor suppressor activity of a novel Beclin1-binding protein UVRAG. Nature Cell Biology, 8 , 688-699.
Naiman, T., and Canaani, D. (1989) A hypodiploid karyotype, found in immortal human cells, is selected from a wide spectrum of posttransformation chromosomal complements. Cancer Genet. and Cytogenet. 40 :65-71.
Perelman, B., Dafni, N., Naiman, T., Eli, D., Yaakov, M., Yang-Feng, T.-L., Sinha, S., Weber, G., Khodaei, S., Sancar, A., Dotan, I., and Canaani, D. (1997) Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus. Genomics 41 : 397-405.
Shenfeld, M., Hachmo, Y., Dafni, N Boettcher M., Hoheisel J, ., Dotan, I., and Canaani, D. (2012) ER a cDNA expressed as part of a bicistronic transcript gives rise to high frequency, long term, receptor expressing cell clones. PLoS One. 7 (2) e31977
Simons, A., Dafni, N., Dotan, I., Oron, Y., and Canaani, D. (2001a) Establishment of a chemical synthetic lethality screen in cultured human cells. Genome Research. 11 : 266-273.
Simons, A.H., Dafni, N., Dotan, I., Oron, Y., and Canaani, D. (2001b) Genetic synthetic lethality screen at the single gene level in cultured human cells. Nucleic Acids Res. 29: e100 (7 pages).
Stark, M., Naiman, T., and Canaani, D. (1989) Ultraviolet light-resistant primary transfectants of xeroderma pigmentosum cells are also DNA repair-proficient. Biochem. Biophys. Res. Commun. 162 :1351-1356.
Teitz, T., Naiman, T., Avissar, S.S., Bar, S., Okayama, H., and Canaani, D. (1987) Complementation of the UV-sensitive phenotype of xeroderma pigmentosum human cell line by transfection with a cDNA clone library. Proc. Natl. Acad. Sci. USA 84 : 8801-8804.
Teitz, T., Naiman, T., Eli, D., Bakhanashvili, M., and Canaani, D. (1988) Stable correction of excision-repair deficiency in a xeroderma pigmentosum human cell line. In: "Mechanisms and Consequences of DNA Damage Processing", UCLA Symposia on Molecular and Cellular Biology, new series, vol. 83, pp. 313-317, ed. E. Friedberg and P. Hanawalt, Alan R. Liss Inc., New York, N.Y.
Teitz, T., Naiman, T., Eli, D., Bakhanashvili, M., and Canaani, D. (1989) Complementation of excision-repair deficiency in a human cell: advantage in the use of a cDNA clone library for gene transfer. In "Gene Transfer and Gene Therapy", UCLA Symposia on Molecular and Cellular Biology, new series, vol. 87, pp. 215-223, eds. A.L. Beaudet, R. Mulligan and I.M. Verma, Alan R. Liss Inc., New York, NY.
Teitz, T., Eli, D., Penner, M., Bakhanashvili, M., Naiman, T., Timme, T.L., Wood, C.M., Moses, R.E., and Canaani, D. (1990a) Expression of the cDNA for the beta subunit of human casein kinase II confers partial UV resistance on xeroderma pigmentosum cells. Mutat. Res. 236 : 85-97.
Teitz, T., Penner, M., Eli, D., Stark, M., Bakhanashvili, M., Naiman, T., and Canaani, D. (1990b) Isolation by polymerase chain reaction of a cDNA whose product partially complements the UV sensitivity of xeroderma pigmentosum group C cells. Gene 87 : 295-298.
Tzadok S., Caspin Y., Hachmo Y., Canaani D., and Dotan I. (2013) Directionality of noncoding human RNAs: how to avoid artifacts. Anal. Biochem. 439: 23-29.
Yang-Feng, T.L., Naiman, T., Kopatz, I., Eli, D., Dafni, N., and Canaani, D. (1994) Assignment of the human casein kinase II a '-subunit gene to 16p13.2-p13.3. Genomics 19 : 173.
Yang-Feng, T.L., Zheng, K., Kopatz, I., Naiman, T., and Canaani, D. (1991) Mapping of the human casein kinase II catalytic subunit genes: two loci carrying the homologous sequences for the a - subunit. Nucleic Acids Res. 19 : 7125-7129.
Yang-Feng, T.L., Teitz, T., Cheung, M.C., Kan, Y.W., and Canaani, D. (1990) Assignment of the human casein kinase II beta-subunit gene to 6p12-p21. Genomics 8 : 741-742.
Patents 1995 U.S. patent 5,882,880 on the human UVRAG gene and its usages - approved 1999. 2000 PCT patent 00956768.6 on Genetic Screening Methods: Chemical and genetic synthetic lethality screens- approved 2005. 1999 U.S. patent 6,569,231 B1 on Genetic Screening Methods: Genetic Synthetic Lethality Screening in Human and Mouse Cells-issued May 2003. 2001 U.S. patent 6,861,220 on Genetic Screening Methods: Chemical Synthetic Lethality Screening in Human and Mouse Cells-issued March 2005.
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