פרופ' גאן ברנרד אטלי

פיזיולוגיה ופרמקולוגיה סגל אקדמי בכיר
ניווט מהיר:
פרופ' גאן ברנרד אטלי
טלפון פנימי: 03-6405116
טלפון נוסף: 03-6405571
פקס: 03-6409113
משרד: רפואה-סאקלר, 546

מידע כללי

פרופ' ברנרד אטלי הוא פרופסור מן המניין במחלקה לפיזיולוגיה בבית הספר לרפואה ע"ש סאקלר באוניברסיטת תל-אביב. הוא פרסם יותר מ-80 מאמרים בכתבי-עת מדעיים מהמובילים בעולם, וזכה בפרסים שונים על מחקריו, ביניהם פרס מטעם הקרן הישראלית לחקר הסרטן ופרס שטאכר של אוניברסיטת תל-אביב.

Biography

Education

1989 Ph.D. Weizmann Institute of Science, Rehovot, Israel
1983 These de 3ieme cycle Paul Sabatier University, Toulouse, France
1980 D.E.A. at the CNRS  Paul Sabatier University, Toulouse, France
1979  B.S.in Pharmacy Paul Sabatier University, Toulouse, France
1976 M.Sc. in Physical Chemistry Paul Sabatier University, Toulouse, France

 

Research

Normal and Diseased Potassium Channels in Human Brain and Heart

Reaching an understanding in molecular terms of the mechanisms by which changes in membrane potential regulate cellular events is the main concern of our research. We focus our interest on potassium channels because they play crucial roles in many cellular functions such as shaping cardiac and neuronal action potentials, tuning neuronal firing patterns, synaptic integration or modulating neurotransmitter release. Using the powerful combination of molecular biology, biophysics, biochemistry and electrophysiology, our research aims at elucidating the structural, biophysical and physiological attributes of potassium channels in human brain and heart and whose mutations lead to major neurological and cardiovascular disorders like epilepsy, myokymia, atrial or ventricular fibrillation.

 

Publications

Manuscripts

Ebner-Bennatan S, Patrich E, Peretz A, Kornilov P, Tiran Z, Elson A, Attali B. (2012) Multi-faceted modulation of K+ channels by protein tyrosine phosphatase epsilon tunes neuronal excitability. J Biol Chem. 287:27614-27628.

 

Weisbrod D, Peretz A, Ziskind A, Menaker N, Oz S, Barad L, Eliyahu S, Itskovitz-Eldor J, Dascal N, Khananshvili D, Binah O, Attali B. (2013) SK4 Ca2+ activated K+ channel is a critical player in cardiac pacemaker derived from human embryonic stem cells. Proc Natl Acad Sci USA. 110:E1685-94.

 

Kornilov P, Peretz A, Lee Y, Son K, Lee JH, Refaeli B, Roz N, Rehavi M, Choi S, Attali B. (2014) Promiscuous gating modifiers target the voltage sensor of Kv7.2, TRPV1, and Hv1 cation channels. FASEB J. 28:2591-602.

 

Gourgy-Hacohen O, Kornilov P, Pittel I, Peretz A, Attali B*, Paas Y* (2014). Capturing distinct KCNQ2 channel resting states by metal ion bridges in the voltage-sensor domain. J Gen Physiol. 144:513-27.


Sachyani D, Dvir M, Strulovich R, Tria G, Tobelaim W, Peretz A, Pongs O, Svergun D, Attali B, Hirsch JA. (2014) Structural basis of a Kv7.1 potassium channel gating module: studies of the intracellular c-terminal domain in complex with calmodulin. Structure. 22:1582-94.

 

Patrich E, Piontkewitz Y, Peretz A, Weiner I, Attali B. (2016). Maturation- and sex-sensitive depression of hippocampal excitatory transmission in a rat schizophrenia model. Brain Behav Immun. 51:240-51.


Patrich E, Piontkewitz Y, Peretz A, Weiner I, Attali B. (2016). Maternal immune activation produces neonatal excitability defects in offspring hippocampal neurons from pregnant rats treated with poly I:C. Sci Rep. 8;6:19106.

 

Reviews

Kornilov P, Peretz A, Attali B. (2013) Channel gating pore: a new therapeutic target. Cell Res. 23:1067-8.

 

Dvir M, Peretz A, Haitin Y, Attali B. (2014) Recent molecular insights from mutated IKS channels in cardiac arrhythmia. Curr Opin Pharmacol. 15:74-82.

 

Alexander SP, Kelly E, Marrion N, Peters JA, Benson HE….Attali, B..et CGTP Collaborators. (2015) The Concise Guide to PHARMACOLOGY 2015/16: Overview. Br J Pharmacol. 172:5729-43. Attali B, Gao ZB. (2016). Ion channels research in the post-genomic era. Acta Pharmacol Sin. 37:1-3.

 

Weisbrod D, Khun SH, Bueno H, Peretz A, Attali B. (2016). Mechanisms underlying the cardiac pacemaker: the role of SK4 calcium-activated potassium channels. Acta Pharmacol Sin. 37:82 -97.

 

Grants

  • 2013-2017 Israel Academy of Science, (ISF:1215/13). Role of SK4 Ca2+- activated K+ channels in the developing human cardiac pacemaker using embryonic stem cell-derived cardiomyocytes as a model. (PI).
  • 2013-2017 Fields Fund for Cardiovascular Research (Co-PI).
  • 2014-2017 Israel Science Foundation-China (The ISF-NSFC joint program, 2092/14)
אוניברסיטת תל-אביב, רחוב חיים לבנון 30, 6997801.
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