ד"ר רועי ויינשטיין

Our lab is developing and utilizing chemical-biology approaches to explore the mechanisms governing hormones signaling in plants. We are interested in studying these mechanisms in a comprehensive manner, from the small-molecule level, all the way to the genome. To this end, we combine techniques from multiple disciplines including organic chemistry, biochemistry, molecular biology and imaging. While most of the tools we are developing are designed to address our main research questions in plants development, we keep an open mind to their broader applicability to other fields of science.

     Rubinstein N., Liu P., Miller E. W., Weinstain R. meso-Methylhydroxy BODIPY: a scaffold for photo-labile protecting groups. Chem. Commun. 2015, 51, 6369-6372.

Weinstain R. , Savariar E., Felsen C., Tsien R. Y. In vivo targeting of hydrogen peroxide by activatable cell-penetrating peptides J. Am. Chem. Soc. 2014, 136(3), 874-877.

Weinstain R. , Kanter J., Friedman B., Ellies L. G., Baker M. , Tsien R. Y. Fluorescent ligand for human progesterone receptor imaging in live cells Bioconjugate Chem. 2013, 24(5), 766-771.

Shani E. * , Weinstain R. *, Zhang y., Castillejo-Mangado C., Kaiserli K. , Chory J., Tsien R. Y., Estelle M. Gibberellins accumulate in the elongating endodermal cells of Arabidopsisroots PNAS 2013, 110, 4834-4839.

* Equal contribution

Sella E., Weinstain R. , Erez R. , Burns N. Z. , Baran P. S., Shabat D. Sulfhydryl-based dendritic chain reaction Chem. Commun. 2010, 46, 6575-6577.

Weinstain R. *, Segal E.*, Satchi-Fainaro R., Shabat D. Real-time monitoring of drug release Chem. Commun. 2010, 46, 553-555.

* Equal contribution

Weinstain R. , Baran P. S., Shabat D. Activity-linked labeling of enzymes by self-immolative polymers Bioconjugate. Chem. 2009, 20(9), 1783-1791.

Weinstain R. , Sagi A., Karton N., Shabat D. Self-immolative comb-polymers: multiple-release of side-chain reporters by a single stimulus event Chem. Eur. J. 2008, 14(23), 6857-6861.

Sagi A., Weinstain R. , Karton N., Shabat D. Self-immolative polymers J. Am. Chem. Soc.2008, 130(16), 5434-5435.

Weinstain R. , Lerner, R. A., Barbas C. F. III., Shabat, D. Antibody-catalyzed asymmetric intramolecular Michael addition of aldehydes and ketones to yield the disfavored cis -product J. Am. Chem. Soc. 2005, 127, 13104-13105.