ד"ר אורנה גרא

ד"ר אורנה גרא, חוקרת ומרצה בביה"ס למקצועות הבריאות, בחוג לפיזיותרפיה.

בעלת תואר ראשון ושני בהצטיינות מהחוג לפיזיותרפיה, תואר שלישי מהחוג לפיזיולוגיה ופרמקולוגיה בפקולטה לרפואה, באוניברסיטת תל אביב.

חוקרת וקלינאית, בעלת ניסיון קליני רב בטיפול בתחום השיקום הנוירולוגי והכללי.

המחקר מתמקד בחקר מחלות של מערכת העצבים המרכזית והפריפרית ומחלות שריר. המחקר נערך במרכז לחקר הנוירולגיה בתל השומר ומתבצע בשורות תאים, בחיות מודל לפגיעות נוירולוגיות, בנבדקים בריאים ובנבדקים הסובלים ממחלת עצב או שריר.

Itsekson-Hayosh, Z., Shavit-Stein, E., Last, D., Goez, D., Daniels, D., Bushi, D., Gera, O., Zibly, Z., Mardor, Y., Chapman, J., & Harnof, S. (2015). Thrombin Activity and Thrombin Receptor in Rat Glioblastoma Model: Possible Markers and Targets for Intervention? Journal of Molecular Neuroscience, 56(3). https://doi.org/10.1007/s12031-015-0512-y

Bushi, D*., Gera, O*., Kostenich, G., Shavit-Stein, E., Weiss, R., Chapman, J., & Tanne, D. (2016). A novel histochemical method for the visualization of thrombin activity in the nervous system. Neuroscience, 320. *Equally contributing first authors. https://doi.org/10.1016/j.neuroscience.2016.01.065

Gera, O., Shavit-Stein, E., Bushi, D., Harnof, S., Shimon, M. Ben, Weiss, R., Golderman, V., Dori, A., Maggio, N., Finegold, K., & Chapman, J. (2016). Thrombin and protein C pathway in peripheral nerve Schwann cells. Neuroscience, 339, 587–598. https://doi.org/10.1016/j.neuroscience.2016.10.034

Bushi, D., Stein, E. S., Golderman, V., Feingold, E., Gera, O., Chapman, J., & Tanne, D. (2017). A linear temporal increase in thrombin activity and loss of its receptor in mouse brain following ischemic stroke. Frontiers in Neurology, 8(APR). https://doi.org/10.3389/fneur.2017.00138

Gera, O., Bushi, D., Ben Shimon, M., Artan-Furman, A., Harnof, S., Maggio, N., Dori, A., Chapman, J., & Shavit-Stein, E. (2018). Local Regulation of Thrombin Activity by Factor Xa in Peripheral Nerve Schwann Cells. Neuroscience. https://doi.org/10.1016/j.neuroscience.2017.12.035

Golderman, V., Shavit-Stein, E., Gera, O., Chapman, J., Eisenkraft, A., & Maggio, N. (2018). Thrombin and the Protease-Activated Receptor-1 in Organophosphate-Induced Status Epilepticus. Journal of Molecular Neuroscience. https://doi.org/10.1007/s12031-018-1228-6

Shavit-Stein, E., Aronovich, R., Sylantiev, C., Gera, O., Gofrit, S. G., Chapman, J., & Dori, A. (2019). Blocking Thrombin Significantly Ameliorates Experimental Autoimmune Neuritis. Frontiers in Neurology, 9(January), 3–12. https://doi.org/10.3389/fneur.2018.01139

Shavit-Stein, E., Sheinberg, E., Golderman, V., Sharabi, S., Wohl, A., Gofrit, S. G., Zivli, Z., Shelestovich, N., Last, D., Guez, D., Daniels, D., Gera, O., Feingold, K., Itsekson-Hayosh, Z., Rosenberg, N., Tamarin, I., Dori, A., Maggio, N., Mardor, Y., … Harnof, S. (2018). A Novel Compound Targeting Protease Receptor 1 Activators for the Treatment of Glioblastoma. Frontiers in Neurology, 9(December), 1–11. https://doi.org/10.3389/fneur.2018.01087

Gera, O., Shavit-Stein, E., & Chapman, J. (2019). The Effect of Neuronal Activity on Glial Thrombin Generation. Journal of Molecular Neuroscience, 67(4), 589–594. https://doi.org/10.1007/s12031-019-01265-4

Golderman, V., Gofrit, S. G., Maggio, N., Gera, O., Gerasimov, A., Laks, D., Chapman, J., & Shavit-Stein, E. (2020). A novel highly sensitive method for measuring inflammatory neural-derived apc activity in glial cell lines, mouse brain and human csf. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms21072422

Mindel, E., Weiss, R., Bushi, D., Gera, O., Orion, D., Chapman, J., & Shavit-Stein, E. (2020). Increased brain plasmin levels following experimental ischemic stroke in male mice. Journal of Neuroscience Research. https://doi.org/10.1002/jnr.24764

Shavit-Stein, E., Gofrit, S. G., Gayster, A., Teldan, Y., Ron, A., Bandora, E. A., Golderman, V., Gera, O., Harnof, S., Chapman, J., & Dori, A. (2020). Treatment of diabetic neuropathy with a novel PAR1-targeting molecule. Biomolecules. https://doi.org/10.3390/biom10111552

Shavit-Stein, E., Rahal, I. A., Bushi, D., Gera, O., Sharon, R., Gofrit, S. G., Pollak, L., Mindel, K., Maggio, N., Kloog, Y., Chapman, J., & Dori, A. (2020). Brain protease activated receptor 1 pathway: A therapeutic target in the superoxide dismutase 1 (SOD1) mouse model of amyotrophic lateral sclerosis. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms21103419

Weiss, R., Bushi, D., Mindel, E., Bitton, A., Diesendruck, Y., Gera, O., Drori, T., Zmira, O., Aharoni, S. A., Agmon-Levin, N., Kashi, O., Benhar, I., Golderman, V., Orion, D., Chapman, J*., & Shavit-Stein, E. (2021). Autoantibodies to Annexin A2 and cerebral thrombosis: Insights from a mouse model. Lupus, 30(5), 775–784. https://doi.org/10.1177/0961203321992117

Greenbaum L., Ben-David M., Nikitin V., Gera O., Barel O., Hersalis-Eldar A., Shamash J., Shimshoviz N.,  Reznik-Wolf H., Shohat M., Dominissini D., Pras E.,. Dori A (2021). Variable manifestations of neuropathy due to HSPB1 mutation in the Jewish Iranian population. Annals of Clinical and Translational Neurology. https://doi.org/10.1002/acn3.51362

Golderman V., Berkowitz S., Guly Grofit S., Gera o., Aharoni S., Zohar D., Keren D., Dori A., Chapman J*., Shavit-Stein E., (2022). Thrombin Activity in Rodent and Human Skin: Modified by Inflammation and Correlates with Innervation. Biomedicines. https://doi.org/10.3390/biomedicines10061461

Gera, O., Shavit‐Stein, E., Amichai, T., Nikitin, V., David, M. B., Greenbaum L., Chapman J*., Dori A. (2023). Exercise induced muscle blood flow is decreased in Charcot–Marie–Tooth disease type 1 polyneuropathy: a power Doppler analysis. European Journal of Neurology. https://doi.org/10.1111/ene.15789

Gera, O., Shavit‐Stein, E., Amichai, Chapman J., Chorin O., Greenbaum L., Dori A. (2024). Muscular dystrophy patients show low exercise-induced blood flow in muscles with normal strength. Annals of Clinical and Translational Neurology. https://doi.org/10.1002/acn3.52194.

Gera O, Ginzburg K, Gur N, Defrin R. Effects of acute stress exposure on pain sensitivity: the role of individual stress responsiveness and orientation to pain and stress. Pain. 2025 May 9. doi: 10.1097/j.pain.0000000000003622.