Prof. Judith Rishpon
Ph.D.: 1978, Weizmann Institute of Science
Phone: (Office) +972-3-640-9366
(Fax) +972-3-640-9407
Room#: Green 239
Member's portrait
  Personal Information
  Research Interests
  Selected Publications

Personal Information


1969 B.Sc. Hebrew University, Jerusalem, Israel, Chemistry
1972 M.Sc Weizmann Institute, Rehovot, Israel, Chemistry
1978 Ph.D. Weizmann Institute, Rehovot, Israel, Chemistry

Title of Master Thesis: "Electrochemical Study of the System Cystine-Cystein Free and Bound in Polypeptide Chain".

Name of Supervisor: Professor I.R. Miller


Title of Doctoral Thesis: "Electrochemical Methods for Studying the Penetration of Proteins and Peptides into Lipid Monolayers".

Name of Supervisor: Professor I. R. Miller

Academic and Professional Experience

1977 Investigator, Research Product, Rehovot
1978-1979 Post Doc., Soil Science, Hebrew University (Jerusalem) & Faculty of Agriculture (Rehovot)
1978 Physics Teacher, Hebrew University (Jerusalem) & Faculty of Agriculture (Rehovot)
1979-1980 Researcher, Extraterrestial biology, NASA Ames Research Center, Moffet Field, California, USA
1980-1984 Researcher, Department of Chemistry, Tel-Aviv University, Tel-Aviv
1984-1987 Researcher, Department of Microbiology and Biotechnology, Tel-Aviv University, Tel-Aviv
1987-1993 Senior Lecturer, Department of Microbiology and Biotechnology, Tel-Aviv University, Tel-Aviv
1988-1994 Collaborator visiting scientist, Electronic research, Los Alamos Natl. Lab,NM, USA
1993-2001 Associate Professor, Department of Microbiology and Biotechnology, Tel-Aviv University, Tel-Aviv
2001- present
Professor, Department of Microbiology and Biotechnology, Tel-Aviv University, Tel-Aviv

Research Interests

Professor Rishpon¹s research is centered on the fundamentals of biological interactions at solid-liquid interfaces with emphasis on electrochemical biosensors.

Current research includes:

  • Novel immunosensors based on enzyme channeling.
  • Biosensors based on enzyme cascades.
  • Electrochemical and optical investigation of the electron transfer reactions of macrocyclic and polymeric mediators and application of their catalytic activity in biosensors.
  • NO sensors; Investigation of the action of the enzyme nitric oxide synthase; measurement of NO in cancer cells.
  • Electrochemical on-line monitoring of gene expression and its application in the detection of environmental pollutants.
  • Interactions of estrogen and xenoestrogen with their hormone-receptors in lipid layers.
  • Biosensors to identify infectious diseases.
  • Biosensors to detect environmental pollutants.
  • Biosensors to detect food safety.
  • Optical evanescent wave biosensors (in cooperation with the Faculty of Engineering).
  • Investigation of tuberculosis KatG peroxidase-catalase reaction and its role in the resistance to isoniazide, the current treatment of choice.

Selected Publications

Publications in refereed journals

1. Barak-Shinar, D., Rosenfeld, M., Rishpon, J., Neufeld, T., and Abboud, S. Computational fluid dynamic model of diffusion and convection processes in electrochemical sensor. Ieee Sensors Journal, 4: 65-71, 2004.

2. Schwartz-Mittelmann, A., Neufeld, T., Biran, D., and Rishpon, J. Electrochemical detection of protein-protein interactions using a yeast two hybrid: 17-beta-estradiol as a model. Analytical Biochemistry, 317: 34-39, 2003.

3. Paitan, Y., Biran, D., Biran, I., Shechter, N., Babai, R., Rishpon, J., and Ron, E. Z. On-line and in situ biosensors for monitoring environmental pollution. Biotechnology Advances, 22: 27-33, 2003.

4. Neufeld, T., Schwartz-Mittelmann, A., Biran, D., Ron, E. Z., and Rishpon, J. Combined phage typing and amperometric detection of released enzymatic activity for the specific identification and quantification of bacteria. Analytical Chemistry, 75: 580-585, 2003.

5. Mittelmann, A. S., Ron, E. Z., and Rishpon, J. Amperometric quantification of total coliforms and specific detection of Escherichia coli. Analytical Chemistry, 74: 903-907, 2002.

6. Granek, V. and Rishpon, J. Detecting endocrine-disrupting compounds by fast impedance measurements. Environmental Science & Technology, 36: 1574-1578, 2002.

7. Campbell, C. E. and Rishpon, J. NADH oxidation at the honey-comb like structure of active carbon: Coupled to formaldehyde and sorbitol dehydrogenases. Electroanalysis, 13: 17-20, 2001.

8. Benhar, I., Eshkenazi, I., Neufeld, T., Opatowsky, J., Shaky, S., and Rishpon, J. Recombinant single chain antibodies in bioelectrochemical sensors. Talanta, 55: 899-907, 2001.

9. Zilbermann, I., Hayon, J., Katchalski, T., Ydgar, R., Rishpon, J., Shames, A. I., Korin, E., and Bettelheim, A. Spectroscopic and electrochemical characterization of the interaction of nitrogen monoxide and cobalt tetrasulfonated phthalocyanine in aqueous solutions and surfactant films. Inorganica Chimica Acta, 305: 53-60, 2000.

10. Sacks, V., Eshkenazi, I., Neufeld, T., Dosoretz, C., and Rishpon, J. Immobilized parathion hydrolase: An amperometric sensor for parathion. Analytical Chemistry, 72: 2055-2058, 2000.

11. Neufeld, T., Eshkenazi, I., Cohen, E., and Rishpon, J. A micro flow injection electrochemical biosensor for organophosphorus pesticides. Biosensors & Bioelectronics, 15: 323-329, 2000.

12. Herschkovitz, Y., Eshkenazi, I., Campbell, C. E., and Rishpon, J. An electrochemical biosensor for formaldehyde. Journal of Electroanalytical Chemistry, 491: 182-187, 2000.

13. Eshkenazi, I., Maltz, E., Zion, B., and Rishpon, J. A three-cascaded-enzymes biosensor to determine lactose concentration in raw milk. Journal of Dairy Science, 83: 1939-1945, 2000.

14. Eshkenazi, I., Sacks, V., Neufeld, T., and Rishpon, J. Amperometric biosensors based on microflow injection system. Applied Biochemistry and Biotechnology, 89: 217-230, 2000.

15. Biran, I., Babai, R., Levcov, K., Rishpon, J., and Ron, E. Z. Online and in situ monitoring of environmental pollutants: electrochemical biosensing of cadmium. Environmental Microbiology, 2: 285-290, 2000.

16. Biran, I., Klimentiy, L., Hengge-Aronis, R., Ron, E. Z., and Rishpon, J. On-line monitoring of gene expression. Microbiology-Uk, 145: 2129-2133, 1999.

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