Personal Information

1969	B.Sc. Hebrew University, Jerusalem, Israel, Chemistry
1972	M.Sc Weizmann Institute, Rehovot, Israel, Chemistry
1978	Ph.D. Weizmann Institute, Rehovot, Israel, Chemistry
Title of Master Thesis: "Electrochemical Study of the System Cystine-Cystein Free and Bound in Polypeptide Chain". Name of Supervisor: Professor I.R. Miller   Title of Doctoral Thesis: "Electrochemical Methods for Studying the Penetration of Proteins and Peptides into Lipid Monolayers". Name of Supervisor: Professor I. R. Miller

Academic and Professional Experience

1977	Investigator, Research Product, Rehovot
1978-1979	Post Doc., Soil Science, Hebrew University (Jerusalem) & Faculty of Agriculture (Rehovot)
1978	Physics Teacher, Hebrew University (Jerusalem) & Faculty of Agriculture (Rehovot)
1979-1980	Researcher, Extraterrestial biology, NASA Ames Research Center, Moffet Field, California, USA
1980-1984	Researcher, Department of Chemistry, Tel-Aviv University, Tel-Aviv
1984-1987	Researcher, Department of Microbiology and Biotechnology, Tel-Aviv University, Tel-Aviv
1987-1993	Senior Lecturer, Department of Microbiology and Biotechnology, Tel-Aviv University, Tel-Aviv
1988-1994	Collaborator visiting scientist, Electronic research, Los Alamos Natl. Lab,NM, USA
1993-2001	Associate Professor, Department of Microbiology and Biotechnology, Tel-Aviv University, Tel-Aviv
2001- present	Professor, Department of Microbiology and Biotechnology, Tel-Aviv University, Tel-Aviv

Research Interests

Current research includes:

• Novel immunosensors based on enzyme channeling.
• Biosensors based on enzyme cascades.
• Electrochemical and optical investigation of the electron transfer reactions of macrocyclic and polymeric mediators and application of their catalytic activity in biosensors.
• NO sensors; Investigation of the action of the enzyme nitric oxide synthase; measurement of NO in cancer cells.
• Electrochemical on-line monitoring of gene expression and its application in the detection of environmental pollutants.
• Interactions of estrogen and xenoestrogen with their hormone-receptors in lipid layers.
• Biosensors to identify infectious diseases.
• Biosensors to detect environmental pollutants.
• Biosensors to detect food safety.
• Optical evanescent wave biosensors (in cooperation with the Faculty of Engineering).
• Investigation of tuberculosis KatG peroxidase-catalase reaction and its role in the resistance to isoniazide, the current treatment of choice.

Selected Publications

1. Barak-Shinar, D., Rosenfeld, M., Rishpon, J., Neufeld, T., and Abboud, S. Computational fluid dynamic model of diffusion and convection processes in electrochemical sensor. Ieee Sensors Journal, 4: 65-71, 2004.

2. Schwartz-Mittelmann, A., Neufeld, T., Biran, D., and Rishpon, J. Electrochemical detection of protein-protein interactions using a yeast two hybrid: 17-beta-estradiol as a model. Analytical Biochemistry, 317: 34-39, 2003.

3. Paitan, Y., Biran, D., Biran, I., Shechter, N., Babai, R., Rishpon, J., and Ron, E. Z. On-line and in situ biosensors for monitoring environmental pollution. Biotechnology Advances, 22: 27-33, 2003.

4. Neufeld, T., Schwartz-Mittelmann, A., Biran, D., Ron, E. Z., and Rishpon, J. Combined phage typing and amperometric detection of released enzymatic activity for the specific identification and quantification of bacteria. Analytical Chemistry, 75: 580-585, 2003.

5. Mittelmann, A. S., Ron, E. Z., and Rishpon, J. Amperometric quantification of total coliforms and specific detection of Escherichia coli. Analytical Chemistry, 74: 903-907, 2002.

6. Granek, V. and Rishpon, J. Detecting endocrine-disrupting compounds by fast impedance measurements. Environmental Science & Technology, 36: 1574-1578, 2002.

7. Campbell, C. E. and Rishpon, J. NADH oxidation at the honey-comb like structure of active carbon: Coupled to formaldehyde and sorbitol dehydrogenases. Electroanalysis, 13: 17-20, 2001.

8. Benhar, I., Eshkenazi, I., Neufeld, T., Opatowsky, J., Shaky, S., and Rishpon, J. Recombinant single chain antibodies in bioelectrochemical sensors. Talanta, 55: 899-907, 2001.

9. Zilbermann, I., Hayon, J., Katchalski, T., Ydgar, R., Rishpon, J., Shames, A. I., Korin, E., and Bettelheim, A. Spectroscopic and electrochemical characterization of the interaction of nitrogen monoxide and cobalt tetrasulfonated phthalocyanine in aqueous solutions and surfactant films. Inorganica Chimica Acta, 305: 53-60, 2000.

10. Sacks, V., Eshkenazi, I., Neufeld, T., Dosoretz, C., and Rishpon, J. Immobilized parathion hydrolase: An amperometric sensor for parathion. Analytical Chemistry, 72: 2055-2058, 2000.

11. Neufeld, T., Eshkenazi, I., Cohen, E., and Rishpon, J. A micro flow injection electrochemical biosensor for organophosphorus pesticides. Biosensors & Bioelectronics, 15: 323-329, 2000.

12. Herschkovitz, Y., Eshkenazi, I., Campbell, C. E., and Rishpon, J. An electrochemical biosensor for formaldehyde. Journal of Electroanalytical Chemistry, 491: 182-187, 2000.

13. Eshkenazi, I., Maltz, E., Zion, B., and Rishpon, J. A three-cascaded-enzymes biosensor to determine lactose concentration in raw milk. Journal of Dairy Science, 83: 1939-1945, 2000.

14. Eshkenazi, I., Sacks, V., Neufeld, T., and Rishpon, J. Amperometric biosensors based on microflow injection system. Applied Biochemistry and Biotechnology, 89: 217-230, 2000.

15. Biran, I., Babai, R., Levcov, K., Rishpon, J., and Ron, E. Z. Online and in situ monitoring of environmental pollutants: electrochemical biosensing of cadmium. Environmental Microbiology, 2: 285-290, 2000.

16. Biran, I., Klimentiy, L., Hengge-Aronis, R., Ron, E. Z., and Rishpon, J. On-line monitoring of gene expression. Microbiology-Uk, 145: 2129-2133, 1999.