Laboratory of Molecular Oncology

Heads of Laboratory: Smadar Avigad Ph.D. and Isaac Yaniv M.D.

	Tel:	972-3-9376775
	E-mail:	savigad@post.tau.ac.il

Research Topics

1. microRNA involvement in pediatric malignancies and their prognostic relevance

2. Defining the molecular pathways leading to progression in Ewing sarcoma

3. Identification of new targets for treatment in pediatric acute lymphoblastic leukemia

Selected Publications

1. Jeison M, Ash S, Halevy-Berko G, Mardoukh J, Luria D, Avigad S, Feinberg-Gorenshtein G, Goshen Y, Kapelushnik J, Stein J, Stark B, Yaniv I. MYCN-gain in neuroblastoma: biological and clinical characteristics Am J Pathol, 176:2616-2625, 2010. MEDLINE

2. Abir R, Feinmesser M, Yaniv I, Fisch B, Cohen IJ, Ben-Haroush A, Meirow D, Felz C, Avigad S. Occasional involvement of the ovary in Ewing sarcoma. Hum Reprod, 25: 1708-1712, 2010 MEDLINE

3. Oberthuer A, Hero B, Berthold F, Juraeva D, Faldum A, Kahlert Y, Asgharzadeh S, Seeger R, Scaruffi P, Tonini GP, Janoueix-Lerosey I, Delattre O, Schleiermacher G, Vandesompele J, Vermeulen J, Speleman F, Noguera R, Piqueras M, Benard J, Valent A, Avigad S, Yaniv I, Weber A, Christiansen H, Grundy RG, Schardt K, Schwab M, Eils R, Warnat P, Kaderali L, Simon T, DeCarolis B, Theissen J, Westermann F, Brors B, Fischer M. The prognostic impact of gene expression-based classification for neuroblastoma. J Clin Oncol, 28: 3506-3515, 2010 MEDLINE

4. Luria D, Rosenthal E, Kodman Y, Safanaiv M, Levanon M, Amariglio N, Avigad S, Stark B, Izraeli S. Comparison of two flow cytometry methods for monitoring minimal residual disease (MRD) in childhood acute lymphoblastic leukemia (ALL): a multicenter study. Cytometry Part BClin Cytom, 78B:365-372, 2010. MEDLINE

5. Ash S, Luria D, Cohen IJ, Goshen Y, Toledano H, Issakov J, Yaniv I, Avigad S. Excellent prognosis in a subset of patients with Ewing sarcoma identified at diagnosis by CD56 using flow cytometry. Clin Cancer Res, 17: 2900-2907, 2011 MEDLINE