The Felsenstein Medical Research Center
TOPIC

Laboratory of Hemato-Oncology

Head of Laboratory: Esther Rabizadeh Ph.D.

Head of Research Group: Yitzhak Charny Ph.D.

 Tel: 972-3-9376634
E-mail: erabi@clalit.org.il
Fax: 972-3-9211478

Research Topics

  1. Development of a novel diagnostic marker for cancer based on the fibrinogen-like protein 2 (FGL-2) (patented).

  2. New insights into the mechanism of resistance in Myeloid Leukemia (Chronic Myeloid Leukemia -CML and Acute Promyelocytic Leukemia -APL).

  3. Cellular and molecular studies of the effect of combining new tyrosine kinase targeted inhibitors and drugs with novel histone deacetylase inhibitors (HDI) in cell line models for CML- Imatinib resistant cells, myeloproliferative disorders (MPD) and Acute Promyelocytic Leukemia (APL).

  4. Study of molecular changes that can predict progression and transformation of myeloproliferative disorders.

Selected Publications

  1. Rabizadeh E, Merkin V, Belyaeva I, Shaklai M, Zimra Y. Pivanex, a histone deacetylase inhibitor, induces changes in BCR-ABL expression and when combined with STI571, acts synergistically in a chronic myelocytic leukemia cell line. Leuk Res. 31:1115-1123, 2007.MEDLINE

  2. Sapoznikov B, Morgenstern S, Raanani P, Aviram A, Rabizadeh E, Prokocimer M, Niv Y. Follicular Lymphoma with extensive gastrointestinal tract involvement : follow-up by Capsule Endoscopy. Dig. Dis. Sci. 52(4) 1031-5, 2007. MEDLINE

  3. Moroz C, Traub L, Rabizadeh E, Zahalka MA. A proof of concept study: human C48-placenta immunoregulatory factor is an effective, single therapeutic agent enabling allogeneic, nonmanipulated murine bone marrow transplantation. Exp Hematol. 37(9):1121-30, 2009. MEDLINE

  4. Mor-Tzuntz R, Uziel O, Shpilberg O, Lahav J, Raanani P, Bakhanashvili M, Rabizadeh E, Zimra Y, Lahav M, Granot G.Effect of imatinib on the signal transduction cascade regulating telomerase activity in K562 (BCR-ABL-positive) cells sensitive and resistant to imatinib. Exp Hematol. 38(1):27-37, 2010. MEDLINE

  5. Grossman A, Green H, Gafter-Gvili A, Zimra Y, Rabizadeh E, Krause I. Co-existence of paroxysmal nocturnal hemoglobinuria and antiphospholipid syndrome-A role for complement activation. Leuk Res 34, e251-3, 2010. MEDLINE.