Biochemistry and Pharmacology of Cancer Cells & Telomere

Head of Laboratory: Jardena Nordenberg Ph.D, Meir Lahav, M.D. M.Sc, Eyal Fenig M.D

Head of Research Group: Orit Uziel Ph.D.

	Tel:	972-3-9376796/7
	Fax:	972-3-9211478
	E-mail:	Meirl2@clalit.org.il, mlahav@post.tau.ac.il, yardenan@clalit.org.il

Research Topics

1. Telomeres and telomerase in cancer

   1. The effect of proteasome inhibitor on telomerase activity and regulation in multiple myeloma cells

   2. The role of BRCA1 in telomere dynamics and telomerase activity in breast epithelial cells

   3. The effect of rapamycin on telomerase regulation and telomere dynamics in cancer cell

   4. Telomerase RNA in the serum of cancer cells as a diagnostic marker for relapse

2. Telomeres and telomerase in various pathological conditions

   1. The effect of ethanol on telomerase regulation and telomere dynamics in endothelial cells

   2. Telomere dynamics in nurses suffering from prolonged stress

   3. Telomere dynamics in response to acute physical stress.

   4. Telomere length heterogeneity and telomerase inducibility in BRCA1,2 carriers

Selected Publications

1. Uziel O, Beery E, Dronichev V, Samocha K, Gryaznov S, Weiss L, Slavin S, Kushnir M, Nordenberg J, Rabinowitz C, Rinkevich B, Zehavi T, Lahav M. Telomere shortening sensitizes cancer cells to selected cytotoxic agents: in vitro and in vivo studies and putative mechanisms. PloS One. 5 (2): e9132, 2010. MEDLINE

2. Tzadok S, Beery E, Israeli M, Uziel O, Lahav M, Fenig E, Gil-Ad I, Weizman A, Nordenberg J. In vitro novel combinations of psychotropics and anti-cancer modalities in U87 human glioblastoma cells. Int J Oncol. 37(4):1043-51, 2010. MEDLINE
3. Shapira S, Granot G, Mor-Tzuntz R, Raanani P, Uziel O, Lahav M, Shpilberg O. Second-generation tyrosine kinase inhibitors reduce telomerase activity in K562 cells. Cancer Lett. 2012 MEDLINE
4. Weiss C, Uziel O, Wolach O, Nordenberg J, Beery E, Bulvick S, Kanfer G, Cohen O, Ram R, Bakhanashvili M, Magen-Nativ H, Shilo N, Lahav M. Differential downregulation of telomerase activity by bortezomib in multiple myeloma cells-multiple regulatory pathways in vitro and ex vivo.Br J Cancer 107(11):1844-52, 2012 MEDLINE
5. Diker-Cohen T, Uziel O, Szyper-Kravitz M, Shapira H, Natur A, Lahav M. The effect of chemotherapy on telomere dynmics: clinical results and possible mechanisms. Leuk Lymphoma 2012 Dec 14. [Epub ahead of print]