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Publications
- 2021: Wang Q, Li Y, Li Y, Osherov N, Goldman GH, Verweij PE, Zheng B, Li R, Chen W, Liang T, Wan Z, Liu W. Triazole-resistant Aspergillus luchuensis, an industrially important black Aspergillus spp. used in fermentation in East Asia, isolated from the patient with invasive pulmonary aspergillosis in China. Emerg Microbes Infect. 2022 May 10:1-9.
- 2021: Charpak-Amikam Y, Lapidus T, Isaacson B, Duev-Cohen A, Levinson T, Elbaz A, Levi-Schaffer F, Osherov N, Bachrach G, Hoyer LL, Korem M, Ben-Ami R, Mandelboim O. Candida albicans evades NK cell elimination via binding of Agglutinin-Like Sequence proteins to the checkpoint receptor TIGIT. Nat Commun. 2022 May 5;13(1):2463.
- 2021: Anabosi D, Meir Z, Shadkchan Y, Handelman M, Abou-Kandil A, Yap A, Urlings D, Gold MS, Krappmann S, Haas H, Osherov N. Transcriptional response of Aspergillus fumigatus to copper and the role of the Cu chaperones. Virulence. 2021 Dec;12(1):2186-2200.
- 2021: Arastehfar A, Carvalho A, Houbraken J, Lombardi L, Garcia-Rubio R, Jenks JD, Rivero-Menendez O, Aljohani R, Jacobsen ID, Berman J, Osherov N, Hedayati MT, Ilkit M, Armstrong-James D, Gabaldón T, Meletiadis J, Kostrzewa M, Pan W, Lass- Flörl C, Perlin DS, Hoenigl M. Aspergillus fumigatus and aspergillosis: From basics to clinics. Stud Mycol. 2021 May 10;100:100115.
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2019: Orasch T, Dietl AM, Shadkchan Y, Binder U, Bauer I, Lass-Flörl C, Osherov N, Haas H. The leucine biosynthetic pathway is crucial for adaptation to iron starvation and virulence in Aspergillus fumigatus. Virulence. 2019 10(1):925-934
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2019: Raffa N, Osherov N, Keller NP. Copper Utilization, Regulation, and Acquisition by Aspergillus fumigatus. Int J Mol Sci. 2019; 20(8).
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2018: Dietl AM, Binder U, Shadkchan Y, Osherov N, Haas H. Siroheme Is Essential for Assimilation of Nitrate and Sulfate as Well as Detoxification of Nitric Oxide but Dispensable for Murine Virulence of Aspergillus fumigatus. Front Microbiol. 2018 12;9:2615.
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2018: Dietl AM, Meir Z, Shadkchan Y, Osherov N, Haas H. Riboflavin and pantothenic acid biosynthesis are crucial for iron homeostasis and virulence in the pathogenic mold Aspergillus fumigatus. Virulence. 2018;9(1):1036-1049.
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2018: Yang K, Shadkchan Y, Tannous J, Landero Figueroa JA, Wiemann P, Osherov N, Wang S, Keller NP. Contribution of ATPase copper transporters in animal but not plant virulence of the crossover pathogen Aspergillus flavus. Virulence.2018;9(1):1273-1286
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2018: Meir Z, Osherov N. Vitamin Biosynthesis as an Antifungal Target. J Fungi (Basel). 2018 17;4(2).
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2018: Bertuzzi M, Hayes GE, Icheoku UJ, van Rhijn N, Denning DW, Osherov N, Bignell EM. Anti-Aspergillus Activities of the Respiratory Epithelium in Health and Disease. J Fungi (Basel). 2018 8;4(1).
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2017: Shemesh E, Hanf B, Hagag S, Attias S, Shadkchan Y, Fichtman B, Harel A, Krüger T, Brakhage AA, Kniemeyer O, Osherov N. Phenotypic and Proteomic Analysis of the Aspergillus fumigatus ?PrtT, ?XprG and ?XprG/?PrtT Protease-Deficient Mutants. Front Microbiol. 2017 12;8:2490.
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2017: Wiemann P, Perevitsky A, Lim FY, Shadkchan Y, Knox BP, Landero Figueora JA, Choera T, Niu M, Steinberger AJ, Wüthrich M, Idol RA, Klein BS, Dinauer MC, Huttenlocher A, Osherov N, Keller NP. Aspergillus fumigatus Copper Export Machinery and Reactive Oxygen Intermediate Defense Counter Host Copper-Mediated Oxidative Antimicrobial Offense. Cell Rep. 2017 6;19(10):2174-2176.
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2017: Ben Yaakov D, Shadkchan Y, Albert N, Kontoyiannis DP, Osherov N. The quinoline bromoquinol exhibits broad-spectrum antifungal activity and induces oxidative stress and apoptosis in Aspergillus fumigatus. J Antimicrob Chemother. 2017 1;72(8):2263-2272.
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2017: Osherov N, Kontoyiannis DP. The anti-Aspergillus drug pipeline: Is the glass half full or empty? Med Mycol. 2017 Jan 1;55(1):118-124. 2016. Review.
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2016: Vitenshtein A, Charpak-Amikam Y, Yamin R, Bauman Y, Isaacson B, Stein N, Berhani O, Dassa L, Gamliel M, Gur C, Glasner A, Gomez C, Ben-Ami R, Osherov N, Cormack BP, Mandelboim O. NK Cell Recognition of Candida glabrata through Binding of NKp46 and NCR1 to Fungal Ligands Epa1, Epa6, and Epa7. Cell Host Microbe. 2016 12;20(4):527-534
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2016: Kaltdorf M, Srivastava M, Gupta SK, Liang C, Binder J, Dietl AM, Meir Z, Haas H, Osherov N, Krappmann S, Dandekar T. Systematic Identification of Anti-Fungal Drug Targets by a Metabolic Network Approach. Front Mol Biosci. 2016 17;3:22.
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2016: Osherov N, Ben-Ami R. Modulation of Host Angiogenesis as a Microbial Survival Strategy and Therapeutic Target. PLoS Pathog. 2016 14;12(4):e1005479.
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2016: Vaknin Y, Hillmann F, Iannitti R, Ben Baruch N, Sandovsky-Losica H, Shadkchan Y, Romani L, Brakhage A, Kniemeyer O, Osherov N. Identification and Characterization of a Novel Aspergillus fumigatus Rhomboid Family Putative Protease, RbdA, Involved in Hypoxia Sensing and Virulence. Infect Immun. 2016 24;84(6):1866-1878.
- 2016: Hover T, Maya T, Ron S, Sandovsky H, Shadkchan Y, Kijner N, Mitiagin Y, Fichtman B, Harel A, Shanks RM, Bruna RE, García-Véscovi E, Osherov N. Analysis of mechanisms of bacterial (Serratia marcescens) attachment, migration and
killing of fungal hyphae. Appl Environ Microbiol. 2016
- 2016: Ben Yaakov D, Rivkin A, Mircus G, Albert N, Dietl AM, Kovalerchick D, Carmeli S, Haas H, Kontoyiannis DP, Osherov N. Identification and characterization of haemofungin, a novel antifungal compound that inhibits the final step of haem biosynthesis. J Antimicrob Chemother. 71(4):946-52.
- 2009: Mircus Gabriel; Hagag Shelly; Levdansky Emma; Sharon Haim; Shadkchan Yona; Shalit Itamar; Osherov Nir Identification of novel cell wall destabilizing antifungal compounds using a conditional Aspergillus nidulans protein kinase C mutant. The Journal of antimicrobial chemotherapy 2009;64(4):755-63.
- 2009: Sharon Haim; Hagag Shelly; Osherov Nir Transcription factor PrtT controls expression of multiple secreted proteases in the human pathogenic mold Aspergillus fumigatus. Infection and immunity 2009;77(9):4051-60.
- 2008: Belaish Ravit; Sharon Haim; Levdansky Emma; Greenstein Shulamit; Shadkchan Yana; Osherov Nir The Aspergillus nidulans cetA and calA genes are involved in conidial germination and cell wall morphogenesis. Fungal genetics and biology : FG & B 2008;45(3):232-42.
2008: Emma LEVDANSKY, Haim SHARON, Nir OSHEROV Coding fungal tandem repeats as generators of fungal
diversity Fungal fungal biology reviews 2008; 1-12
- 2007: Shuster Amir; Osherov Nir; Leikin-Frenkel Alicia; Rosenberg Mel Alcohol-conferred hemolysis in yeast is a consequence of increased respiratory burden.
FEMS yeast research 2007;7(6):879-86.
- 2007: Levdansky Emma; Romano Jacob; Shadkchan Yona; Sharon Haim; Verstrepen Kevin J; Fink Gerald R; Osherov Nir Coding tandem repeats generate diversity in Aspergillus fumigatus genes. Eukaryotic cell 2007;6(8):1380-91.
- 2007: Ronen Revital; Sharon Haim; Levdansky Emma; Romano Jacob; Shadkchan Yona; Osherov Nir The Aspergillus nidulans pkcA gene is involved in polarized growth, morphogenesis and maintenance of cell wall integrity. Current genetics 2007;51(5):321-9.
- 2006: Romano Jacob; Nimrod Guy; Ben-Tal Nir; Shadkchan Yona; Baruch Koti; Sharon Haim; Osherov Nir Disruption of the Aspergillus fumigatus ECM33 homologue results in rapid conidial germination, antifungal resistance and hypervirulence. Microbiology 2006;152(Pt 7):1919-28.
- 2006: Shalit Itamar; Halperin Drora; Haite Debby; Levitov Avital; Romano Jacob; Osherov Nir; Fabian Ina Anti-inflammatory effects of moxifloxacin on IL-8, IL-1beta and TNF-alpha secretion and NFkappaB and MAP-kinase activation in human monocytes stimulated with Aspergillus fumigatus. The Journal of antimicrobial chemotherapy 2006;57(2):230-5.
- 2006: Greenstein Shulamit; Shadkchan Yona; Jadoun Jeries; Sharon Chaim; Markovich Sarit; Osherov Nir Analysis of the Aspergillus nidulans thaumatin-like cetA gene and evidence for transcriptional repression of pyr4 expression in the cetA-disrupted strain. Fungal genetics and biology : FG & B 2006;43(1):42-53.
- 2006: Wendland Jürgen; Hellwig Daniela; Walther Andrea; Sickinger Stefan; Shadkchan Yona; Martin Ronny; Bauer Janine; Osherov Nir; Tretiakov Alexander; Saluz Hans-Peter Use of the Porcine Intestinal Epithelium (PIE)-Assay to analyze early stages of colonization by the human fungal pathogen Candida albicans.
Journal of basic microbiology 2006;46(6):513-23.
- 2004: Shuster Amir; Osherov Nir; Rosenberg Mel Alcohol-mediated haemolysis in yeast. Yeast 2004;21(16):1335-42.
- 2004: Markovich Sarit; Yekutiel Aya; Shalit Itamar; Shadkchan Yona; Osherov Nir Genomic approach to identification of mutations affecting caspofungin susceptibility in Saccharomyces cerevisiae. Antimicrobial agents and chemotherapy 2004;48(10):3871-6.
- 2004: Yekutiel Aya; Shalit Itamar; Shadkchan Yona; Osherov Nir In vitro activity of caspofungin combined with sulfamethoxazole against clinical isolates of Aspergillus spp. Antimicrobial agents and chemotherapy 2004;48(9):3279-83.
- 2004: Kogan Tanya V; Jadoun Jeries; Mittelman Leonid; Hirschberg Koret; Osherov Nir Involvement of secreted Aspergillus fumigatus proteases in disruption of the actin fiber cytoskeleton and loss of focal adhesion sites in infected A549 lung pneumocytes. The Journal of infectious diseases 2004;189(11):1965-73.
- 2004: Shadkchan Yona; Shemesh Einav; Mirelman David; Miron Talia; Rabinkov Aharon; Wilchek Meir; Osherov Nir Efficacy of allicin, the reactive molecule of garlic, in inhibiting Aspergillus spp. in vitro, and in a murine model of disseminated aspergillosis. The Journal of antimicrobial chemotherapy 2004;53(5):832-6.
- 2004: Jadoun Jeries; Shadkchan Yona; Osherov Nir Disruption of the Aspergillus fumigatus argB gene using a novel in vitro transposon-based mutagenesis approach.
Current genetics 2004;45(4):235-41.
- 2003: Shalit Itamar; Shadkchan Yona; Samra Zmira; Osherov Nir In vitro synergy of caspofungin and itraconazole against Aspergillus spp.: MIC versus minimal effective concentration end points. Antimicrobial agents and chemotherapy 2003;47(4):1416-8.
- 2003: Kontoyiannis Dimitrios P; Lewis Russell E; Osherov Nir; Albert Nathaniel D; May Gregory S Combination of caspofungin with inhibitors of the calcineurin pathway attenuates growth in vitro in Aspergillus species. The Journal of antimicrobial chemotherapy 2003;51(2):313-6.
- 2002: Kontoyiannis D P; Lewis R E; May G S; Osherov N; Rinaldi M G Aspergillus nidulans is frequently resistant to amphotericin B. Mycoses 2002;45(9-10):406-7.
- 2002: Osherov Nir; Mathew John; Romans Angela; May Gregory S Identification of conidial-enriched transcripts in Aspergillus nidulans using suppression subtractive hybridization. Fungal genetics and biology : FG & B 2002;37(2):197-204.
- 2002: Osherov Nir; May Gregory S; Albert Nathaniel D; Kontoyiannis D P Overexpression of Sbe2p, a Golgi protein, results in resistance to caspofungin in Saccharomyces cerevisiae. Antimicrobial agents and chemotherapy 2002;46(8):2462-9.
- 2001: Liu X; Osherov N; Yamashita R; Brzeska H; Korn E D; May G S Myosin I mutants with only 1% of wild-type actin-activated MgATPase activity retain essential in vivo function(s). Proceedings of the National Academy of Sciences of the United States of America 2001;98(16):9122-7.
- 2001: Osherov N; Kontoyiannis D P; Romans A; May G S Resistance to itraconazole in Aspergillus nidulans and Aspergillus fumigatus is conferred by extra copies of the A. nidulans P-450 14alpha-demethylase gene, pdmA. The Journal of antimicrobial chemotherapy 2001;48(1):75-81.
- 2001: Osherov N; May G S The molecular mechanisms of conidial germination. FEMS microbiology letters 2001;199(2):153-60.
- 2000: Osherov N; Mathew J; May G S Polarity-defective mutants of Aspergillus nidulans. Fungal genetics and biology : FG & B 2000;31(3):181-8.
- 2000: Osherov N; May G S In vivo function of class I myosins. Cell motility and the cytoskeleton 2000;47(3):163-73.
- 2000: Osherov N; May G Conidial germination in Aspergillus nidulans requires RAS signaling and protein synthesis. Genetics 2000;155(2):647-56.
- 2000: Yamashita R A; Osherov N; May G S Localization of wild type and mutant class I myosin proteins in Aspergillus nidulans using GFP-fusion proteins.
Cell motility and the cytoskeleton 2000;45(2):163-72.
- 1998: Osherov N; Yamashita R A; Chung Y S; May G S Structural requirements for in vivo myosin I function in Aspergillus nidulans. The Journal of biological chemistry 1998;273(41):27017-25.
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