The Felsenstein Medical Research Center
Immunology

Laboratory of Molecular Immunology

Head of Laboratory: Chaya Moroz Ph.D.

 Telephone: 972-3-937-6741
Fax: 972-3-924-7019
E-mail: hmoroz@post.tau.ac.il

Research Topics

  1. Isolation and cloning of the PLIF receptor from human T cells and monocytes.

  2. PLIF signal transduction in immune cells.

  3. The effects of PLIF on diabetes development and therapy in mouse models.

  4. Effect of anti-PLIF antibodies on human breast cancer development.

Selected Publications:

  1. Weinberger A, Halpern M, Zahalka MA, Quintana F, Traub L, Moroz C. PLIF- a novel immunoregulator suppressed experimental arthritis. Arthritis & Rheumatism 48: 846-853, 2003.MEDLINE

  2. Nahum R, Brenner O, Zahalka MA, Traub L, Quintana F, Moroz C. Blocking of the placental immune-modulatory ferritin activates Th1 type cytokines and affects placenta development, fetal growth and the pregnancy outcome. Hum Reprod 19:715-22, 2004. MEDLINE

  3. Moroz C, Grunspan A, Zahalka MA, Traub L, Kodman Y, Yaniv I. Treatment of human bone marrow with recombinant Placenta Immunoregulator Ferritin (PLIF) results in myelopoiesis and T cell suppression through modulation of the cytokine-chemokine networks. Exp Hematol 34, 159-166, 2006. MEDLINE

  4. Halpern M, Zhalka MA, Traub L, Moroz C. Antibodies to placental Immunoregulatory ferritin with transfer of polyclonal lymphocytes arrests MCF-7 human breast cancer growth in a nude mouse model. Neoplasia 9, 487-494, 2007. MEDLINE

  5. Moroz C, Traub L, Rabizadeh E, Zahalka MA. A proof of concept study: Human C48-placenta immunoregulatory factor is an effective, single therapeutic agent enabling allogeneic, nonmanipulated murine bone marrow transplantation. Exp Hematol 37:1121-1130, 2009. MEDLINE