Laboratory of Inflammation Research

Head of Laboratory: Yair Molad M.D.

Head of Research Group: Vered Carmon Ph.D.

	Tel:	972-3-9376278
	Fax:	972-3-9211478
	E-mail:	ymolad@post.tau.ac.il

Current Research Topics

1. Soluble TREM-1 molecule in serum of patients with SLE and other rheumatic disorders.

2. Toll-like receptor and TREM-1 in autoimmune diseases: study of signal transduction pathways.

3. Role of TREM-1 and TREM-2 in the pathogenesis of autoimmune disease in a mouse model of rheumatoid arthritis and systemic lupus erythematosus

4. TREM-1 in gout: its role in the resolution of crystal-indcued arthritis and the activation of the inflammasome

Selected Publications:

1. Bar J, Bardin R, Chen R, Pardo J, Hod M, Peled Y, Molad Y. Surface expression of neutrophil adhesion molecules in pregnant women at risk of hypertensive complications. Hypertension in Pregnancy 22: 165-172, 2003. MEDLINE
2. Molad Y, Konstantino Y, Bloch K, Sulkes J, Weingarten MA. Costitutively increased neutrophil surface expression of 2-integrin in Yemenite Jews: Clue to the mechanism of benign familial neutropenia. Inflammation 27: 301-305, 2003. MEDLINE
3. Molad Y, Fridenberg A, Bloch K, Langevitz P, Mukamel M, Sulkes J, Pras M, Livneh A. Neutrophil adhesion molecule expression in familial Mediterranean fever: discordance between the intravascular regulation of beta2 integrin and L-selectin expression in acute attack. J Investig Med. 52: 58-61, 2004. MEDLINE
4. Ochaion A, Bar Yehuda S, Cohen S, Del Valle L, Perez-Liz G, Madi L, Barer F, Farbstein M, Fishman-Furman S, Reitblat T, Reitblat A, Molad Y, Mader R, Tishler M, Langevitz P, Zabutti A, Fishman P. Methotrexate enhances the anti-inflammatory effect of CF101 via up-regulation of the A3 adenosine receptor expression. Arthritis Res Ther, 8:R169, 2006. MEDLINE
5. Bishara J, Hadari N, Shalita-Chesner M, Samra Z, Ofir O, Paul M, Peled N, Pitlik S, Molad Y. Soluble triggering receptor expressed on myeloid cells-1 for distinguishing bacterial from aseptic meningitis in adults. Eur J Clin Microbiol Infect Dis 26: 647-50, 2007. MEDLINE