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ENC 2005

The 15th European Neuropeptide Club Annual Meeting was held in Riga, Latvia, World Trade Center, May 19 - 21, 2005

Meeting Chairs:

Prof. Mara Pilmane	Prof. Manfred Zimmermann
Dept. Anatomy, Stradins University	Neuroscience & Pain Research Institute
Riga, Latvia	Heidelberg, Germany
Pilmane@com.latnet.lv	manzimm@aol.com

Secretariat:
Ms. Inese Balcune
Department for Public Relations
Riga Stradins University
16 Dzieciema Street
Riga, LV 1007
Phone: 371 7409223
Fax: 371 7471815
E-mail: enc2005@rsu.lv

PROGRAM

TOPICS for ENC Riga 2005:

Orexins and their role in central and peripheral homeostasis

Peptide and peptide receptor trafficking

Neurosecretory cells/NC granule biosynthesis/ Neuroendocrine effects

Galanin and galanin receptor biology

Neuropeptides in cutaneous immunity

Neuropeptides in drug discovery

MEETING PROGRAMME World Trade Center Riga , 2 Elizabetes Street , Riga , Latvia

19/05/2005
9.00 – 10.00	Registration
10.00 – 11.00	Opening Ceremony	Rector/RSU; President/LAS; Chairmens/ENC2005 – 15 min 1^st key note lecture – Tomas Hökfelt ( Sweden ) – How to decipher the role of neuropeptides: focus on their receptors - 45 min
11.00 – 11.30	Coffee break
11.30 – 12.45	Session	2^nd key note lecture – Frank Sundler ( Sweden ) – CART peptide expression and actions in the periphery: Focus on the islets - 45 min Orexins: Jyrki Kukkonen ( Sweden ) – A brief history of orexins/hypocretins and cellular signaling mechanisms of orexin receptors – 30 min
12.45 – 14.45	Lunch
14.45 – 16.00	Session	Orexins and their role in central and peripheral homeostasis/Chairmen Jyrki Kukkonen ( Sweden ) Speakers: Shahrad Taheri ( UK ): Orexins, sleep, and narcolepsy – 40 min; John Rodgers ( UK ) - Orexins and appetite regulation: Focus on orexin-1 receptors – 35 min
16.00 – 16.30	Coffee break
16.30 – 18.00	Session	Poster session I Chairmens Mara Pilmane ( Latvia ) and Jerzy Nowak ( Poland )
20.00 – 23.00	Welcome Party
20/05/2005
9.30 – 11.00	Session	Galanin and GalR biology/Chairmens Tomas Hökfelt ( Sweden ) and Barbara Kofler ( Austria ) Speakers: Linda Lundström ( Sweden ): Design and development of galanin receptor subtype specific ligands – 30 min Xiao-Jun ( Sweden ): Galanin and spinal nociceptive mechanisms: recent results from transgenic and knock-out models – 30 min Barbara Kofler ( Austria ): Expression and function of galanin in the skin – 30 min
11.00 – 11.30	Coffee break
11.30 – 12.45	Session	Neuropeptides in cutaneous immunity/Chairmen Susan Brain ( UK ) and Martin Steinhoff ( Germany ) Speakers: Erika Pinter ( Hungary ) - Regulatory role of sensory neurogenic componens in inflammatory skin diseases – 30 min Manfred Zimmermann ( Germany ) - CGRP released from cutaneous nerve terminals is involved in UV induced cutaneous immunosuppression – 20 min Martin Steinhoff ( Germany ) – Neuropeptides and human skin conditions – 25 min Anna Starr ( UK ) – short communication
12.45 – 14.45	Lunch
14.45 – 16.00	Session	Neuropeptides in drug discovery/Chairmen Illana Gozes (Israel) Speakers: Hari Shanker Sharma (Sweden) - Opioid receptors and neuroprotection in CNS injury – 20 min, Illana Gozes (Israel) – Neuroprotection: peptides downstream of VIP – 25 min Jerzy Z. Nowak (Poland) – The effects of PHI, PACAP and VIP on cyclic AMP frmation in cultures of rat astrocytes and C6 glioma cells – 30 min
16.00 – 16.30	Coffee break
16.30 – 17.30	Session	Poster session II Chairmens Manfred Zimmermann ( Germany ) and Eberhard Weihe ( Germany )
19.00 – 23.00	Gala Evening Party
21/05/2005
9.30 – 11.00	Session	3d key note lecture – Xu Zhang ( China ) – Opioid receptor trafficking in primary sensory neurons - 45 min Peptide and peptide receptor trafficking/Chairmen Xu Zhang ( China ) Antonio Silva (Switzerland, Novartis) - Regulation of ghrelin secretion by the somatostatin analogues SOM230 and octreotide – 20 min Zhi-Qing David Xu ( Sweden ) - Visualization of EGFP-tagged galanin receptor trafficking: focus on GALR1 and GALR2 in PC12 cells – 25 min
11.00 – 11.30	Coffee break
11.30 – 12.20	Selected communications	Chairmen Janos Szolcsanyi ( Hungary )
12.20 – 13.00		End of Sessions and Conclusions. ENC business meeting

Meeting report:

ENC Business Meeting
Riga , 2005

Meeting Co-Chairs:

Mara Pilmane ( Latvia )

Manfred Zimmermann Heidelberg ( Germany )

ENC Secretary:

Illana Gozes Tel Aviv ( Israel )

ENC Committee:

Chair: Daniel Hoyer Basel ( Switzerland ), absent due to previous commitment

Vice-chair: Manfred Zimmermann Heidelberg ( Germany )

Secretary: Illana Gozes Tel Aviv ( Israel )

Treasurer: Riccardo Patacchini Firenze (Italy) absent due to previous commitment

The meeting in Riga was a great success with 94 participants from 17 countries. Two first prize poster awards from Joint Stock Company Grindeks were given to Santic Radmila (Salzburg, Austria) for the work Alternative splice variants of the galanin–like peptide gene and to Szabó Árpad (Pécs, Hungary) for the work Role of the capsaicin VR1/TRPV1 receptor in bleomycin–induced scleroderma in the mouse.

Three second prize awards were given to Sokołowska Paulina (Lodz, Poland) for the poster Effect on PACAP and related peptides on cAMP synthesis in C6 glioma cells, to Babjoniseva Aurika (Riga, Latvia) for the poster Distribution and concentration of vasoactive intestinal peptide ( VIP ) and substance P (SP) in bronchi of patients with mild and moderate bronchial asthma, and to Engström Mia (Turku, Finland)for the presentation Differential efficacies of somatostatin receptor agonists for G–protein activation and desensitization of the human somatostatin receptor subtype 4–mediated responses.

The ENC Riga meeting material will be published in the Sept/Oct 2005 issue of Neuropeptides (volume 39, issue 5).

In the business meeting we discussed the next meeting (s) location and suggestions were Miami, Ferrara, Budapest and Salzburg. There was a vote for Miami for next year (joint with the American Summer Neuropeptide Meeting). Ferrara and Salzburg and Budapest were voted for the following years (2007, 2008, 2009). The American Summer Neuropeptide Meeting will be invited to Salzburg.

Thanks,

Prof. Illana Gozes, Ph.D.
Secretary General
European Neuropeptides Club