The Felsenstein Medical Research Center
Neurobiology and Psychiatry
Neurobiology and Psychiatry Research Groups
  • Biological Psychiatry
  • Eye Research
  • Neurosciences
  • Pediatric Eye Research

    • All Research Groups

    Laboratory of Neurosciences

    Head of Laboratory: Daniel Offen Ph.D.

     Tel: 972-3-9376130
    Fax: 972-3-9211478
    E-mail: doffen@post.tau.ac.il

    Research Topics

    1. Induce differentiation of adult stem cells by genetic manipulation

    2. Cell/gene therapy in neurodegenerative diseases

    3. Neurogenesis in Alzheimer's diseases

    4. Peptide-base therapy in Parkinson's and Huntington diseases

    5. Applications of adult stem cells in models of Schizophrenia and Autism

    Selected Publications

    1. Barzilay R, Ben-Zur T, Sadan O, Bren Z, Taler M, Lev N, Uzan R., Gil-Ad I., Melamed E., Weizman A., Offen D. Intracerebral adult stem cells transplantation increases brain-derived neurotrophic factor levels and protects against hencyclidine-induced social deficit in mice. Transl Psychiatry 2011 Dec 13;1:e61. doi: 10.1038/tp.2011.64. MEDLINE

    2. Dadon- Nachum M, Ben-Zur T, Srugo I, Shamir M, Melamed E, Yaffe D, Offen D, Therapeutic effect of myogenic cells modified to express neurotrophic factors in a rat model of sciatic nerve injury, Journal of Stem Cells & Regenerative Medicine, 2012 In press.

    3. Benkler C, Ben-Zur T, Barhum Y, Offen D. Altered astrocytic response to activation in SOD1G93A mice and its implications on amyotrophic lateral sclerosis pathogenesis. Glia. 61:312-26, 2013. MEDLINE

    4. Glat M, Offen D., Cell and gene therapy in Alzheimer disease. Stem Cells Dev 2013 MEDLINE

    5. Lev N, Barhum Y, Pilosof NS, Ickowicz D, Cohen HY, Melamed E, Offen D. DJ-1 protects against dopamine toxicity: implications for Parkinson's disease and aging. J Gerontol A Biol Sci Med Sci 68:215-25, 2013. MEDLINE


      6. Link for all publications of this Laboratory: http://www.ncbi.nlm.nih.gov/pubmed/?term=offen+d%2C