Neuroendocrine Laboratory Research

Head of Laboratory: Ilan Shimon M.D.

Head of Research Group: Hadara Rubinfeld Ph.D.

	Tel:	972-3-9377184
	Fax:	972-3-9211403
	E-mail:	ilanshi@clalit.org.il

Research Topics

1. IGF-1 induces cell proliferation in human pituitary tumors - functional blockade of the IGF-1 receptor as a novel therapeutic approach in non-functioning tumors.

2. Combined treatments targeting the RTK-GPCR/PI3K/Akt/mTOR pathway as a novel therapeutic approach in neuroendocrine tumors.

3. Characterization of the expression and function of the glioma tumor suppressor candidate region 2 gene product (GLTSCR2) in neuroendocrine tumors.

4. mTOR inhibitor Torin1 induces antiproliferative effects in MtT/E cell line and human pituitary tumors.

Selected Publications:

1. Grozinsky-Glasberg S, Rubinfeld H, Gorshtein A, Prais M, Kendler E, Feinmesser R, Grossman AB and Shimon I. The rapamycin derivative RAD001 (Everolimus) inhibits cell viability and interacts with the Akt-mTOR-P70S6K pathway in human medullary thyroid carcinoma cells. Mol Cell Endocrinol. 315:87-94, 2010. MEDLINE

2. Rubinfeld H, Cohen-Kaplan V, Nass D, Ilan N, Meisel S, Cohen ZR, Hadani M, Vlodavsky I and Shimon I. Heparanase is highly expressed and regulates proliferation in GH-secreting pituitary tumor cells. Endocrinology 152(12):4562-70, 2011. MEDLINE

3. Grozinsky-Glasberg S, Shimon I, Rubinfeld H. The role of cell lines in the study of neuroendocrine tumors. Neuroendocrinology, 2012. MEDLINE

4. Rubinfeld H, Shimon I. PI3K/Akt/mTOR and Raf/MEK/ERK signaling pathways perturbations in non-functioning pituitary adenomas. Endocrine, 2012. MEDLINE

5. Rubinfeld H, Kammer A, Cohen O, Gorshtein A, Cohen ZR, Hadani M, Werner H and Shimon I. IGF-1 Induces proliferation in human pituitary tumors - functional blockade of igf-1 receptor as a novel therapeutic approach in non-functioning tumors. Endocr Relat Cancer. In revision.