Laboratory of Biochemical Genetics

Head of Laboratory: Amos Frisch Ph.D.

	Tel:	972-3-9376793/62,   972-528481043
	Fax:	972-3-9211478
	E-mail:	afrisch@post.tau.ac.il

Research Topics

1. Molecular genetic analysis of mental and behavioral disorders in patients with the del22q11.2 syndrome.
2. Pharmacogenetics of antidepressant (citalopram) treatment in children and adolescents.
3. Genetic and environmental factors in health behaviors (smoking, alcohol consumption, etc) in Israel.
4. Susceptibility genes for suicidal behavior.
5. Neurogenetics of neuropsychiatric disorders (in collaboration with Prof. Abraham Weizman)

Selected Publications

1. Gothelf D, Frisch A, Michaelovsky E, Weizman A, Shprintzen RJ. Velo-Cardio-Facial Syndrome. J Ment Health Res Intellect Disabil. 2(2):149-167, 2009. MEDLINE

2. Schirman S, Kronenberg S, Apter A, Brent D, Melhem N, Pick N, Carmel M, Frisch A, Weizman A, Gothelf D. Effectiveness and tolerability of citalopram for the treatment of depression and anxiety disorders in children and adolescents: an open-label study. J Neural Transm. 117(1):139-45, 2010. MEDLINE

3. Green T, Weinberger R, Diamond A, Berant M, Hirschfeld L, Frisch A, Zarchi O, Weizman A, Gothelf D. The effect of methylphenidate on prefrontal cognitive functioning, inattention, and hyperactivity in Velocardiofacial Syndrome. J Child Adolesc Psychopharmacol. 2011 Dec; 21(6): 589-95. MEDLINE

4. Shmulewitz D, Keyes KM, Wall MM, Aharonovich E, Aivadyan C, Greenstein E, Spivak B, Weizman A, Frisch A, Grant BF, Hasin D. Nicotine dependence, abuse and craving: dimensionality in an Israeli sample. Addiction. 106(9):1675-86, 2011. MEDLINE

5. Zalsman G, Patya M, Frisch A, Ofek H, Schapir L, Blum I et al. Association of polymorphisms of the serotonergic pathways with clinical traits of impulsive-aggression and suicidality in adolescents: a multi-center study. World J Biol Psychiatry 2(1): 33-41, 2011 MEDLINE