PBL Sessions: Immunologic Diseases


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Page 8

Further History (Sarah):

Therapy with attenuated androgens (Danazol/Stanozolol) is given. She has no recurrences of edema over the next month.

Further History (Madge):

Laboratory Findings - Autoantibodies:

  • ANA - positve

  • anti-dsDNA - positive

  • anti-histone - negative

  • anti-RNP - negative

  • RF - negative

  • anti-SSA - negative

  • anti-SSB - negative

Coombs test: positive

Further History (Jack):

He is improving on the biotherapy with rituximab.

Tasks

  • What do these findings indicate?

  • What hypotheses explain these findings?

  • Explain your reasoning for the hypotheses you choose.

  • Can you explain the pathophysiology of the disease processes in these family members?

  • Review the pharmacologic agents given to them and their effects.

Stop !! Complete discussions and tasks before moving to the next page.