On upper GI endoscopy above is an area of angiodysplasia. This condition, more common in older persons, is a cause for GI tract bleeding. One or more foci of irregular dilated venous or capillary channels are present in the submucosa, typically of the colon, but occasionally elsewhere. The lesions are often quite small, less than 0.5 cm, making them hard to find. Colonoscopy and mesenteric angiography can be performed for diagnosis. The histologic appearance is shown below, with multiple dilated vessels in the lamina propria and submucosa.

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