Pulmonary Pathology, Set 2

For each of the following patients, select the most likely pathologic finding:

1. A chest radiograph reveals a 2 cm right mid-lung subpeural nodule along with mediastinal lymphadenopathy in a 17-year-old woman who recently developed a cough with fever:

2. A 60-year-old gold prospector who has worked his Arizona desert claim by "dry washing" (sifting the dirt and sand using a screen and the wind) now has increasing dyspnea developing over several years' time. Pulmonary function testing reveals a low FVC and a normal FEV1/FVC ratio:

3. Sudden dyspnea with wheezing is noted in a 5-year-old child. A chest radiograph reveals bilateral increased lucency of lung fields consistent with hyperinflation. The complete blood count (CBC) reveals eosinophilia:

4. A 53-year-old woman has increasing dyspnea along with fever over the past 6 weeks. A chest radiograph reveals pulmonary reticulonodular infiltrates and also marked hilar lymphadenopathy. A sputum for acid fast bacilli is negative. A transbronchial biopsy shows small non-caseating granulomas:

5. A 37-year-old man has alpha-1-antitrypsin deficiency with the PiZZ genotype:

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