Hepatic Pathology, Set 3

For each of the following clinical histories, match the most characteristic, diagnostic hepatic morphologic finding:

1. A 50-year-old man has developed increasing dyspnea over the past 5 years as a consequence of a pneumoconiosis. He now has a serum AST of 221 U/L, ALT 234 U/L, LDH 710 U/L, total bilirubin 1.2 mg/dL, alkaline phosphatase 48 U/L, albumin 3.5 g/dL, and total protein 5.4 g/dl. He develops cor pulmonale with ascites and peripheral edema:

2. A neonate develops neonatal hepatitis and is found to have the PiZZ genotype for alpha-1-antitrypsin deficiency:

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A. Apoptosis B. Central venular sclerosis C. Centrilobular congestion D. Cholangiocarcinoma
E. Cholangitis F. Cholestasis G. Granulomatous bile duct destruction H. Hemosiderin deposition
I. Hepatocellular carcinoma J. Macrovesicular steatosis K. Mallory bodies L. Metastatic adenocarcinoma
M. Neutrophilic infiltration N. Periportal PAS-positive globules O. Piecemeal necrosis P. Portal ̃brosis