Hepatic Pathology Set 2

For each of the following patients, select the most likely pathologic finding:

1. Increased urinary copper excretion is noted in a 17-year-old adolescent with worsening liver function:

2. A markedly increased anti-mitochondrial antibody titer is found in a 45-year-old woman who has had worsening pruritis in the absence of visible skin lesions:

3. A 40-year-old man has worsening arthritis of his knees and hands. He notes increasing darkening of his skin, but he has not been out in the sun. He has pedal edema and orthopnea. Laboratory findings include serum glucose of 181 mg/dL, total protein 6.3 g/dL, albumin 3.3 g/dL, total bilirubin 1.1 mg/dL, alkaline phosphatase 45 U/L, AST 24 U/L, ALT 27 U/L, and ferritin 1245 ng/mL:

4. The HAV IgM is positive in a 35-year-old woman with scleral icterus and mild nausea and vomiting for the past week:

5. A healthy 26-year-old man develops mild scleral icterus during a bout of influenza. He has no abdominal pain, nausea, or vomiting. He has a total bilirubin of 4.5 mg/dl and the direct bilirubin is 0.8 mg/dl:

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