Hematopathology Set 2

For each of the following patients, select the most likely pathologic finding:

1. A 9-year-old boy from Uganda has a mass lesion involving the right neck and face region. The mass is resected and consists of a monomorphous population of cells that mark with CD20. Karyotyping of these cells reveals a t(8;14) abnormality:

2. A 48-year-old man has a CBC that shows Hgb 22.1 g/dl, Hct 67.2%, WBC count 9800/microliter, and platelet count 175,000/microliter:

3. A 37-year-old man has a WBC count of 57,750/microliter; the leukocyte alkaline phosphatase (LAP) score on a peripheral blood smear is high:

4. A 15-year-old girl has increasing fatigue for the past month. Her CBC shows WBC count 1500/microliter, Hgb 6.9 g/dL, Hct 21%, MCV 100 fL, and platelet count 23,000/microliter. A posterior iliac crest bone marrow biopsy shows fatty marrow with rare erythroid islands:

5. A 47-year-old man has increasing abdominal discomfort for the past three months. An abdominal CT scan reveals massive splenomegaly. He has a normocytic anemia. The B-cells in the peripheral blood have cytoplasmic projections and stain for tartrate-resistant acid phosphatase:

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