Hematopathology, Set 3

For each of the following patient histories, match the most closely associated lettered hematologic condition that produces anemia:

1. A 54-year-old woman presents with the sudden onset of headaches with photophobia worsening for the past two days. She has a temperature of 37 degrees Celsius. A complete blood count shows a hemoglobin of 11.2 g/dL, hematocrit 33.7%, MCV 94 fL, platelet count 32,000/microliter, and WBC count 9900/microliter. The peripheral blood smear demonstrates many schistocytes. Her serum urea nitrogen is 38 mg/dL with creatinine 3.9 mg/dL:

2. A 45-year-old woman has a long history of rheumatoid arthritis. She has a complete blood count that reveals the following: hemoglobin 11.6 g/dL, hematocrit 34.8%, MCV 87 fL, platelet count 268,000/microliter, and WBC count 6800/microliter. The serum haptoglobin is not decreased. The serum iron is 20 micrograms/dL; total iron binding capacity 195 micrograms/dL, and % saturation 10.2. The serum ferritin is 317 nanogram/mL. Her D-dimer is negative. The reticulocyte count is 1.1%:

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A. Acute blood loss B. Alpha-thalassemia major C. Anemia of chronic disease D. Beta-thalassemia major
E. Disseminated intravascular coagulation F. Erythroblastosis fetalis G. Hemoglobin C disease H. Hemolytic-uremic syndrome
I. Hereditary spherocytosis J. Idiopathic thrombocytopenic purpura K. Iron deficiency anemia L. Megaloblastic anemia
M. Paroxysymal nocturnal hemoglobinuria N. Sickle cell anemia O. Thrombotic thrombocytopenic purpura P. Warm autoimmune hemolytic anemia