Neuropathology, Set 1

For each of the following patients, select the most likely pathologic finding:

1. A 31-year-old man, known to be seropositive for human immunodeficiency virus infecton for the past 8 years, has worsening headaches, and MR imaging of the brain reveals a 4 cm mass involving the right globus pallidus. Stereotactic biopsy of this mass reveals large cells with high N/C ratio that mark with CD3 by immunoperoxidase staining:

2. An 85-year-old woman has superficial subfrontal and temporal cortical hemorrhages by head CT scan following a fall down the stairs at home causing her to fall backwards, striking the back of her head:

3. MR imaging reveals periventricular plaques of demyelination in the white matter of a 33-year-old man who had manifested difficulty with vision and with movement of his right arm:

4. A 70-year-old man had a history of progressive cognitive decline over the past 7 years. He had no movement disorder. At autopsy, microscopic sections of his cerebral cortex reveal many neuritic plaques with amyloid cores:

5. A 60-year-old man had a course of rapidly progressive dementia for six months along with myoclonus. At autopsy, the brain shows no grossly evident abnormalities, but microscopically there is a spongiform encephalopathy of the cerebral cortex:

- GO TO: NEXT SET - - INDEX - -