A "hot" joint that is swollen and tender may indicate an acute suppurative arthritis. The gram stain shown here shows many neutrophilic leukocytes, one of which contains gram negative intracellular diplococci indicative of Neisseria gonorrheae infection.

Infectious agents may reach the joint via penetrating trauma or hematogenously. In adults, a major risk is sepsis with injection drug use. Sexually active adults are at risk for gonococcal arthritis. The organisms that may often produce a pyogenic arthritis are:

ORGANISMPEAK AGE INCIDENCEGRAM STAIN
Hemophilus influenzaeChildrenGram negative coccobacilli
Neisseria gonorrheaeYoung adultsGram negative diplococci
SalmonellaChildren & young adults with sickle cell anemiaGram negative rods
Staphylococcus aureusAdultsGram positive cocci in clusters
Escherichia coliAdultsGram negative rods
PseudomonasAdultsGram negative rods