Our laboratory investigates the DNA damage response. This research stems from our interest in the human genetic disorder ataxia-telangiectasia (A-T), in which a central axis of the DNA damage response is missing.

The DNA damage response is the cornerstone of a sophisticated system that maintains the stability and integrity of the cellular genome. It is an intricate network of signaling pathways that is rapidly activated following the induction of various DNA lesions - most notably, one of the most dangerous ones – double strand breaks.

To investigate this system we use cell biology methods, gene targeting in mice, and systems biology methods including high-throughput screens, advanced proteomics and bioinformatics.