Our Research

Metagenomics, Machine learning, Molecular microbiology, and Fun!

We strive to better understand key interaction mechanisms within microbial communities and to promote their application in biotechnology and medicine. By combining state-of-the-art machine learning, molecular biology, and metagenomic techniques, we decipher functions in the nexus of microbial interactions, such as CRISPR-Cas, anti-CRISPRs, antibiotic resistance genes, and bacterial secretion systems.

If you're interested to learn about “reading” microbial genomes using language models, the experiments we conducted in the international space station, or how plasmids protect themselves against systems such as CRISPR-Cas, we invite you to read about our research projects here.


Publications Highlights

GeNLP: a web tool for
NLP-based exploration of microbial gene function
Bioinformatics 2024

A diverse repertoire of anti-defense systems is encoded in the leading region of plasmids
bioRxiv 2023

CRISPR-Based Genetic Diagnostics in Microgravity
Biosensors and Bioelectronics 2023

Deciphering microbial gene function using natural language processing
Nature Communications 2022

Programmed DNA destruction by miniature CRISPR-Cas14 enzymes
Science 2018

New CRISPR–Cas systems from uncultivated microorganisms
Nature 2017

Major bacterial lineages are essentially devoid of CRISPR-Cas viral defence systems
Nature Communications 2016

Genomic analysis of 38 Legionella species identifies diverse effector repertoires
Nature Genetics 2016

Computational modeling and experimental validation of the type-IVB secretion signal
PNAS 2013


Our Team

David (Dudu) Burstein

Principal Investigator

Karin Mittelman

Research Associate

Bruria Samuel

Ph.D. Student

Danielle Miller

Ph.D. Student
(joint with Prof. Adi Stern)

Ella Rannon

Ph.D. Student

Shirley Croitoru

Ph.D. Student

Guy Shur

Ph.D. Student

Maya Ben Haim

M.Sc. Student

Edan Gabay

M.Sc. Student

Ori Ben-Shir

M.Sc. Student

Nadav Shalev

M.Sc. Student

Chen Agassy

M.Sc. Student

Tomer Parket

Data Analyst

Ortal Peretz


Ofir Arias

Software Specialist

Asaf Zorea

Research Engineer


Stay in Touch

Green building, room 239
Office: +972-3-640-8715
Lab: +972-3-640-7525
Fax: +972-3-642-2046