Fibrofatty replacement of the pancreas, with only remaining islets of Langerhans, is illustrated here in a patient with cystic fibrosis. About 90% of cystic fibrosis patients have pancreatic abnormalities ranging from mild duct dilation to marked plugging of the ducts with mucus, progressive fibrosis, and eventual fibrofatty replacement of the exocrine pancreas. With longer survival of cystic fibrosis patients, nutritional problems from malabsorption with loss of pancreatic function may become more common.

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