PBL Sessions: Vascular Diseases 2


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Page 7

History of Present Illness:

You obtain additional laboratory testing that includes: Factor V Leiden mutation - negative; Prothrombin G20210A mutation positive, dilute Russel viper venom assay negative; factor VIII level normal; antithrombin III level normal, protein C level normal, and protein S level normal. His plasma homocysteine level is normal.

Tasks

  • What do these findings indicate?

  • What hypotheses explain these findings?

  • Explain your reasoning for the hypotheses you choose.

  • Can you explain the pathophysiology of the disease process in this patient?

  • What therapy, if any, needs to be given?

Stop !! Complete discussions and tasks before moving to the next page.