PBL Sessions: Hematology Organ System - 1
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Page 6
History of Present Illness:
Additional laboratory findings on the patient, who now has a markedly decreased level of consciousness, include direct and indirect Coombs tests which are negative and a serum haptoglobin of 5 mg/dL.
You look further in the laboratory reports of the deceased husband and discover that flow cytometry was performed with the following results:
| Measurement | Patient | Normal Range
| | Helper T-cells: absolute CD4+ | 97 | 443-1345
| | Suppresser T-cells: absolute CD8+ | 410 | 171-914
| | Total T-cells: absolute | 541 | 782-2204
| | CD4/CD8 ratio | 0.2 | 0.8-3.5
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Tasks
What do these findings indicate?
What hypotheses explain these findings?
Explain your reasoning for the hypotheses you choose.
Is there anything that can tie these findings together?
What laboratory test(s) would you order on this patient?
Stop !! Complete discussions and tasks before moving to the next page.
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