One of the most common causes for splenomegaly is portal hypertension with cirrhosis of the liver. Micronodular cirrhosis from chronic alcoholism is more common in the U.S. than macronodular cirrhosis following hepatitis B or C infection. Note that this spleen also shows irregular tan-white fibrous plaques over the purple surface. This "sugar icing" has the name hyaline perisplenitis.

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