Bone Pathology, Set 2

For each of the following patients, select the most likely pathologic finding:

1. A 10-year-old boy has intense pain in his left thigh region for the past month. A radiograph of his upper left leg reveals a small 0.8 cm lucent area in the upper femur that is surrounded by a dense rim of sclerotic bone:

2. A 30-year-old woman has noted pain in the region of her knee on the left for the past few weeks. A radiograph reveals a mass involving the distal left femur. This mass is expansile, with a "soap bubble" appearance in the region of the epiphysis. The bone cortex is thinned but not broken through:

3. An 18-year-old man has pain about the right knee for two months. A radiograph reveals a mass in the metaphysis of the upper right tibia. There is erosion of the overlying cortical bone. A biopsy of the mass reveals atypical spindle cells forming an osteoid matrix:

4. A 75-year-old woman has had a poor diet for several years following the death of her husband who provided the household income. She develops vitamin D deficiency which results in hip fracture:

5. A 55-year-old man has pain in his right hip region. A radiograph reveals a 10 cm mass with bony destruction involving the right ischium. A biopsy reveals atypical cartilagenous cells:

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