email: kosower@post.tau.ac.il
Voice: 972-3-6408556
Fax: 972-3-6409293
Building: Shenkar
Room: 216


  • Charge-transfer complexes.


  • Electron-transfer reactions.


  • Bimanes (Chemistry, photophysics, physical chemistry, applications to biology, polymers for strength and/or conductivity).


  • Modeling of biological receptors and channels.


  • Surface enhanced infrared absorption spectroscopy on planar AgX fibers.


  • Molecular graphics of receptor proteins and channels.


  • Tetrones and complex derivatives.


  • Fluorescent affinity labels.


  • Anti-leishmaniasis/anti-trypanosomiasis compounds.



L.Friedman & E.M.Kosower , Org.Syn. 26, 42-44 (1946). "Preparation of a-ketoglutaric acid".

E.M.Kosower , Science 113, 605-606 (1951). "Biosynthesis of cyclopropane rings"

E.M.Kosower and S.Winstein, J. Am. Chem. Soc. 78, 4354-4358 (1956). "Neighboring carbon and hydrogen XXIII. Homoallylic systems. 3,5-Cyclocholestan-6b-yl chloride".

E.M.Kosower , J. Am. Chem. Soc. 80, 3253-3260 (1958). "The effect of solvent on spectra I. A new empirical measure of solvent polarity: Z-values".

E.M.Kosower , "Charge-transfer complexing of pyridinium rings", Chap.13, Vol. III. pp.171-194, "The Enzymes", Academic Press, New York (1960).

E.M.Kosower , "Molecular Biochemistry", 304 pp., McGraw-Hill, New York (1962).

E.M.Kosower & E.J.Poziomek, J. Am. Chem. Soc. 86, 5515-5523 (1964). "Stable free radicals I. Preparation and isolation of 1-ethyl-4-carbomethoxy-pyridinyl".

E.M.Kosower , An Introduction to Physical Organic Chemistry , 503 pp., John Wiley & Sons, New York (1968).

E.M.Kosower & N.S.Kosower , Nature 224, 117-20 (1969). "Lest I forget thee, glutathione.."

N.S.Kosower , E.M.Kosower , B.Wertheim & W.Correa, Biochem. Biophys. Res. Comm. 37, 593-596 (1969). "Diamide, a new reagent for the intracellular oxidation of glutathione to the disulfide".

E.M.Kosower , Accts. Chem. Res. 4, 193-198 (1971). "Monosubstituted diazenes (diimides) - Surprising intermediates".

R.Werman, P.L.Carlen, M.Kushnir & E.M.Kosower , Nature New Biol. 233, 120-121 (1971). "Effect of the thiol-oxidizing agent, diamide, on acetylcholine release at the frog endplate".

E.M.Kosower , N.S.Kosower , Z.Faltin, A.Diver, G.Saltoun & A.Frensdorff, Biochim. Biophys. Acta 363, 261-266 (1974). "Membrane mobility agents: A new class of biologically active molecules".

N.S.Kosower , E.M.Kosower & P.Wegman, Biochem. Biophys. Acta 401, 530-533 (1975). "Membrane mobility agents II. Active promoters of cell fusion"

E.M. Kosower & H. Kanety-Londner, J. Am. Chem. Soc. 98, 3001-3007 (1976). "Glutathione XIII. mechanism of thiol oxidation by diazenedicarboxylic acid derivatives".

E.M.Kosower , N.S.Kosower & P.Wegman, Biochim. Biophys. Acta 471, 311-329 (1977). "Membrane mobility agents IV. The mechanism of particle-cell and cell-cell fusion".

N.S.Kosower & E.M.Kosower , Internat. Rev. of Cytology 54, 109-160 (1978). "The Glutathione (GSH) Status of Cells".

N.S.Kosower , E.M.Kosower , G.L.Newton and H.M.Ranney, Proc. Nat'l. Acad. Sci. USA 76, 3382-3386 (1979). "Bimane fluorescent labels: Labeling of normal human red cells under physiological conditions".

E.M.Kosower , Accounts Chem. Res. 15, 259-266 (1982). "Photophysics of phenylaminonaphthalene-sulfonates: A paradigm for excited state intramolecular electron transfer".

D.Huppert, H.Kanety & E.M.Kosower , Disc. Faraday Soc. 74, 161-175 (disc.194-203) (1982). "Kinetics and mechanism of intramolecular electron transfer in solution".

E.M.Kosower & D.Huppert, Ann. Revs. Phys. Chem. 37, 127-156 (1986). "Excited state electron and proton transfers".

E.M.Kosower , Eur. J. Biochem. 168, 431-449 (1987) "A structural and dynamic model for the acetylcholine receptor".

E.M.Kosower , Proc. Nat'l. Acad. Sci. USA 85, 1076-1080 (1988). "Assignment of the groups responsible for the "opsin shift" and the light absorptions of rhodopsin and red, green and blue iodopsins (cone pigments)".

E.M.Kosower , "Molecular Mechanisms for Sensory Signals: Recognition and Transformation", Princeton University Press, Princeton, 438pp (1991).

Streitwieser,A., Heathcock,C.H. & Kosower ,E.M., Introduction to Organic Chemistry, 4th edn., Macmillan, New York, 1256pp + 11pp. appendices + 32 pp. index (1992).

Stella M. Chiacchiera & Edward M. Kosower , Anal. Biochem., 201, 43-47 (1992). "Deuterium exchange on micrograms of proteins by attenuated total reflection Fourier transform infrared spectroscopy on silver halide fibers".

E.M.Kosower & N.S. Kosower , in "Biothiols", Chap. 12, Vol. 251, Methods in Enzymology, Academic Press, Orlando, Fla, 1995. "Bromobimane Probes for Thiols", pp.133-148.

N.S.Kosower & E.M.Kosower , in "Biothiols", Chap. 11, Vol. 251, Methods in Enzymology, Academic Press, Orlando, Fla, 1995. "Diamide, an Oxidant Probe for Thiols", pp.123-133.

Kosower,E.M., Pure & Applied Chem. 69, 249-254 (1997). "Rethinking physical organic chemistry".

E.M.Kosower, G. Markovich.,Y. Raichlin,, G.Borz, A.Katzir, J. Phys. Chem. B 108, 12633-12636 (2004). “Surface-Enhanced Infrared Absorption and Amplified Spectra on Planar Silver Halide Fiber”

E.M.Kosower, G. Markovich, G.Borz, J. Phys. Chem. B, 108, 12873-12876 (2004) “Surface-Enhanced Infrared Absorption of p-Nitrobenzoic Acid on Planar Silver Halide Fiber”