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The Bat-Sheva de Rothschild Seminar on Innate Immunity
Zichron Yaakov, Israel October 10-15, 1999 |
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Synopsis
General Information
Seminar fees
Deadlines
Seminar Chairpersons
Secretariat
Registration form
| 19:00 | Informal Get Together |
| 19:45 | Dinner |
| 09:00 - 13:00 Session A: Receptors and cytokines in innate immunity | ||||
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| 09:00 | Introduction | |||
| 09:25 | Siamon Gordon, Oxford Univ., UK ROLE OF MANNOSE AND SCAVENGER RECEPTORS IN INNATE AND ACQUIRED IMMUNITY | |||
| 10:05 | Philip Stahl, Washington Univ. St. Louis, USA SIGNAL TRANSDUCTION AND THE INTERPLAY BETWEEN THE EARLY ENDOCYTIC AND PHAGOCYTIC PATHWAYS | |||
| Coffee Break | ||||
| 11:15 | Eithan Yefenof, Hebrew Univ., Israel CR3: A PUBLIC TRANSDUCER OF INNATE IMMUNITY SIGNALS IN MACROPHAGES | |||
| 11:45 | Ron Apte, Ben Gurion Univ., Israel TISSUE DISTRIBUTION OF CYTOKINES: DIFFERENTIAL ROLE OF IL-1  AND IL-1
IN INNATE IMMUNITY | |||
| 12:15 | Judith Leibovici, Tel-Aviv Univ., Israel MACROPHAGE - RECOGNIZED MOLECULES ON APOPTOTIC CELLS ARE EXPRESSED AT HIGHER LEVEL IN AKR LYMPHOMA OF AGED AS COMPARED TO YOUNG MICE | |||
| 12:30 | Shraga Segal, Ben Gurion Univ., Beer Sheba, Israel Overview: THE ROLE OF INTERLEUKIN 1 RECEPTOR ASSOCIATED MOTIFS IN THE REGULATION OF INNATE IMMUNITY (EVOLUTIONARY ASPECTS) | |||
| Lunch | ||||
| 15:30-18:20 Session B: Chemotaxis and cell trafficking | ||||
| Chair: Ofer Lider, Weizmann Inst., Israel | ||||
| 15:30 | Alberto Mantovani, Mario Negri Inst. & Univ. Brescia, Italy REGULATION OF CHEMOKINE AND CHEMOKINE RECEPTOR EXPRESSION IN INNATE IMMUNITY | |||
| 16:10 | Catharina Svanborg, Univ. Lund, Sweden DEFECTS IN NEUTROPHIL TRAFFICKING AND SUSCEPTIBILITY TO BACTERIAL INFECTION | |||
| Coffee Break | ||||
| 17:10 | Amos Etzioni, Rambam Hospital & Technion Med. Sch. Israel ON HUMAN AND MICE-THE ADHESION MOLECULES EXPERIMENTS | |||
| 17:45 | O. Lider, Weizmann Inst. Israel EFFECT OF THE EXTRACELLULAR MATRIX CONTENT ON METALLOPROTEINASE SECRETION BY MONOCYTES | |||
| Dinner | ||||
| Guided tour in Zichron Yaakov | ||||
| 09:00-13:00 Session C: Lectins and Collectins | ||||
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| 09:00 | Introduction | |||
| 09:10 | R. Alan B. Ezekowitz, MGH & Harvard Univ., Boston, USA PATTERN RECOGNITION IN FIRST LINE HOST DEFENSE | |||
| 09:50 | Sheena A. Linehan, Oxford Univ., UK MANNOSE RECEPTOR LIGANDS: DETECTION IN SITU IN NORMAL AND PATHOLOGIC SETTINGS | |||
| 10:05 | Dror Mevorach, Sourasky Med. Ctr. & Tel-Aviv Univ., Israel CLEARANCE OF APOPTOTIC CELLS IS MEDIATED BY THE COMPLEMENT SYSTEM | |||
| 10:20 | Yona Keisari, Tel Aviv Univ., Israel ROLE OF CYTOKINES IN THE EXPRESSION AND FUNCTION OF MACROPHAGE RECEPTORS | |||
| Coffee Break | ||||
| 11:15 | Erika C. Crouch, Washington Univ. St. Louis, USA SURFACTANT PROTEIN D IN INNATE IMMUNITY | |||
| 11:55 | Moshe Kalina, Tel Aviv Univ., Israel MODULATION OF THE INNATE IMMUNE RESPONSE IN THE LUNG BY SURFACTANT PROTEINS AND LIPIDS. | |||
| 12:25 | Kevan Hartshorn, Boston University, USA DEVELOPMENT OF CHIMERIC COLLECTINS WITH ENHANCED ACTIVITY AGAINST INFLUENZA A VIRUSES | |||
| 12:45 | Adi Mesika, Tel-Aviv Univ., Israel STIMULATION OF NO AND INTERLEUKIN PRODUCTION IN MACROPHAGES BY Klebsiella pneumoniae AND LUNG COLLECTIN SURFACTANT PROTEIN D (SPD) | |||
| Lunch | ||||
| 14:15 | Optional: Guided Tour to Caesaria, Mount Carmel and Zichron Yaakov | |||
| Dinner | ||||
| 09:00-13:00 Session D: Interactions between pathogens and components of innate immunity | ||||
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| 09:00 | Introduction | |||
| 09:10 | Itzhak Ofek, Tel Aviv Univ., Israel THE ROLE OF C-TYPE LECTINS IN THE INNATE IMMUNITY AGAINST PULMONARY PATHOGENS | |||
| 09:45 | Yossi Mekori, Meir Med. Ctr. & Tel Aviv Univ., Israel MAST CELL-LYMPHOCYTE INTERACTION: MUTUAL FUNCTIONAL RELATIONSHIPS IN INNATE IMMUNITY | |||
| 10:15 | Soman N. Abraham, Duke Univ. Durham, USA THE ROLE OF MAST CELLS IN INNATE IMMUNITY | |||
| Coffee Break | ||||
| 11:15 | Ofer Mandelboim, Hebrew Univ., Israel THE ROLE OF NK CELLS IN INNATE IMMUNITY | |||
| 11:45 | Benjamin Sredni, Bar Ilan Univ., Israel ROLE OF TELLURIUM COMPOUNDS AS BIOLOGICAL RESPONSE MODIFIERS IN THE ACTIVATION OF INNATE IMMUNITY | |||
| 12:15 | Inbal Hazan-Halevy, Ben-Gurion Univ. Israel REQUIREMENT OF BOTH ERK AND P38 MAP-KINASE FOR CYTOSOLIC PHOSPHOLIPASE A2 ACTIVITY STIMULATED BY FC  RIIA AND FCRIIIB IN HUMAN NEUTROPHILS | |||
| 12:30 | Vladimir L. Katanaev, Univ. of Fribourg, Switzerland SIGNALLING BY G PROTEIN-COUPLED PHOSPHOINOSITIDE 3-KINASE G - NEUTROPHIL RESPONSES IN PI3KG KNOCK-OUT MICE | |||
| 12:45 | Yaffa Mizrachi, Ben Gurion Univ., Israel INITIAL STEPS IN Streptococcus pneumoniae INTERACTION WITH AND PATHOGENICITY TO THE HOST | |||
| Lunch | ||||
| 16:00-18:10 Session E: Poster session | ||||
| Dinner | ||||
| Social Program | ||||
| 09:00-10:30 Session F: NADPH oxidases | |
| Chair: Angello Messina, Univ. Catania, Italy | |
| 09:00 | Introduction |
| 09:10 | Edgar Pick, Tel Aviv Univ. Israel ASSEMBLY OF THE SUPEROXIDE GENERATING NADPH OXIDASE: TAKING PEPTIDES FOR A WALK |
| 09:45 | Karl-Heinz Krause, Geneva Univ. Hospitals, Switzerland H+ CHANNELS AND NADPH OXIDASES: FROM PROFESSIONAL PHAGOCYTES TO NON-PHAGOCYTIC CELLS |
| 10:20 | Rachel Levy, Ben Gurion Univ. Israel THE ROLE OF CYTOSOLIC PHOSPHOLIPASE A2 FOR ACTIVATION OF THE H+ CHANNEL IN PHAGOCYTE-LIKE CELLS |
| Coffee Break | |
| 11:15-13:00 Session G: Innate immunity in the compromised host | |
| Chair: Justin Passwell, Sheva Med. Ctr & Tel-Aviv Univ., Israel | |
| Yitzhak Katz, Assaf-Harofeh Hosp. & Tel-Aviv Univ., Israel EXTRAHEPATIC SYNTHESIS OF COMPLEMENT PROTEINS IN FIBROBLASTS: A CONVENIENT CELLULAR SOURCE TO STUDY COMPLEMENT DEFICIENCY STATES | |
| Baruch Wolach, Meir Hosp. & Tel-Aviv Univ., Israel THE CLINICAL SIGNIFICANCE OF NEUTROPHIL DYSFUNCTION | |
| Hany Sahly, Christian Albrechts Univ., Kiel, Germany KLEBSIELLA INFECTIONS IN THE IMMUNOCOMPROMISED HOST | |
| Zeev Handzel, Kaplan Med. Ctr. & Hebrew Univ. Med. School, Israel CLINICAL SIGNIFICANCE OF MACROPHAGE CYTOCHEMOKINE REGULATION DEFECTS | |
| General Discussion | |
| Lunch | |
| 16:00-18:10 Session H: Anti microbial peptides | |
| Chair: Matti Fridkin, Weizmann Institute, Israel | |
| 16:00 | Introduction |
| 16:10 | Michael E. Zasloff, USA SQUALAMINE: AN ANTIBIOTIC AMINOSTEROL FROM THE SHARK WITH POTENT ANTIANGIOGENIC ACTIVITY |
| 16:45 | Yechiel Shai, Weizmann Inst., Israel HOW DO ANTIMICROBIAL PEPTIDES SELECTIVELY LYSE BACTERIA: FROM NATIVE TO DE-NOVO DESIGNED PEPTIDES |
| 17:20 | Margherita Zanetti, Univ. of Udine, Italy MOLECULAR ANALYSIS OF THE HORSE CATHELICIDIN GENE FAMILY |
| 17:55 | Haim Tsubery, Weizmann Inst., Israel BIOLOGICAL ACTIVITIES OF POLYMYXIN B NONAPEPTIDE ANALOGS |
| 21:00 | Farewell party at the "Haykev Club" including dinner |
| 09:00-12:30 Session I: The interrelationship between acquired and innate immunity | |
| Chair: Michal Shapira, Ben Gurion Univ., Israel | |
| 09:00 | Introduction |
| 09:10 | Isaac P. Witz, Tel Aviv Univ., Israel NATURALLY-OCCURRING ANTIBODIES: A HUMORAL COMPONENT OF INNATE IMMUNITY |
| 10:40 | Yehuda Shoenfeld, Sheba Med. Ctr. & Tel Aviv Univ., Israel INTRAVENOUS GAMMAGLOBULIN (IVIG) HARNESSING THE INNATE IMMUNITY TO TREAT AUTOIMMUNITY AND MALIGNANCY |
| Coffee Break | |
| 11:30 | Angel Porgador, Ben Gurion Univ., Israel DNA-BASED VACCINES: THE ROLE OF DENDRITIC CELLS IN ANTIGEN PRESENTATION |
| 12:00 | Heidrun Moll, Univ. Wurzburg, Germany THE ROLE OF DENDRITIC CELLS AT THE EARLY STAGES OF LEISHMANIA INFECTION |
| 12:30 | Concluding remarks |
| Lunch | |
* The program is subject to changes.