Adi Stern


Ph.D. Student in the department of Cell Biology and Immunology at Tel-Aviv Uni.
under the supervision of Dr.Tal Pupko



Contact info
E-mail: sternadi@post.tau.ac.il
Tel.: 03-6409245
Fax.: 03-6422046
"Imagination is more important than knowledge" (Albert Einstein)
Research Interests

- Modelling protein evolution
- Computational virology
- Positive and purifying selection in proteins
- Lateral gene transfer


Teaching

Fall 2007-2008: Introduction to bioinformatics

The lab gang

Itay Mayrose
Adi Doron
Nimrod Rubinstein
David Burstein
Eyal Privman
Osnat Penn (Zomer)
Ofir Cohen
Tal Peled
Daiana Alaluf
Article in Haaretz on 10 promising PhD students

My CV

Publications

Sela N, Stern, A., Pupko, T., Ast, G. Transduplication resulted in incorporation of a conserved protein domain sequence within the transposable element Harbinger Turmoil-1 in C. elegans. Biology Direct. 2008 Oct 8;3:41

Penn O.*, Stern A.*, Rubinstein N., Dutheil J., Bacharach E., Galtier N., Pupko T. 2008. Evolutionary modeling of rate shifts reveals specificity determinants in HIV-1 subtypes. PLoS Computational Biology. 2008 Nov;4(11):e1000214. *Authors contributed equally.

Cohen, O., Rubinstein, ND., Stern, A., Gophna, U., and Pupko, T. A likelihood framework to analyze phyletic patterns. Proceedings of The Royal Society of London Series B-Biological Sciences. 2008 Dec 27;363(1512):3903-11.

Stern A., Mayrose I., Shaul S., Gophna U., Pupko T. An Evolutionary Analysis of Lateral Gene Transfer in Thymidylate Synthase Enzymes. In press.

Stern, A., Doron-Faigenboim, A., Erez, E., Martz, E., Bacharach, E., Pupko, T. Selecton 2007: advanced models for detecting positive and purifying selection using a Bayesian inference approach. Nucleic Acids Research. 35: W506-W511.[pdf] [abs]

Stern, A., Privman, E., Rasis, M., Lavi, S., Pupko, T. 2007. Evolution of the metazoan protein phosphatase 2C superfamily.
J. Mol. Evol. 64(1):61-70. [pdf] [abs]

Stern, A., Pupko, T. 2006. An Evolutionary Space-Time Model with Varying Among Site Dependencies.
Mol. Biol. Evol. 23: 392-400 [pdf] [abs]

Doron-Faigenboim, A.*, Stern, A.*, Mayrose, I., Bacharach, E., and Pupko, T. 2005. Selecton: a server for detecting evolutionary forces at a single amino-acid site. Bioinformatics. 21(9): 2101-2103. *Authors contributed equally. [pdf] [abs]

Presentations

Selecton: A Web Server for the Detection of Site-Specific Positive Darwinian Selection and Purifying Selection (Software Demonstration). 5th European Conference on Computational Biology (ECCB 2006). Eilat, Israel. January 2007.

An Evolutionary Space-time model with Varying among Site Dependencies (Oral presentation). Annual meeting for the Society for Molecular Biology and Evolution. Tempe, Arizona. May 2006.

Stern A., Pupko T. Poster at MEP 2005, France: An Evolutionary Space-time model with Varying among Site Dependencies.

Stern A., Pupko T., Poster at the Center for Complexity Science Meeting: Predicting Functional Regions in a Protein Using a Hidden Markov Model [ppt]

Doron-Faigenboim, A., Stern, A., Mayrose, I., Cohen, O., Rubinstein, N., Bacharach, E., Pupko, T., Poster at the Israeli Bioinformatics Symposium, IBS 2004: A Server for Detecting Selection at a Single Amino-Acid Site [pdf]
Links

RASER software - inferring rate shifts
LGT3State - detecting LGT (swapping) of two non-homologous enzymes
Selecton Server - detecing site-specific selection
Consurf Server - estimating sites specific rate of evolution
Pepsurf Server - epitope mapping


Algorithm Summaries

Branch length optimization using Expectation Maximization (EM)
Neighbour Joining Algorithm (Saitou and Nei)
Jukes and Cantor one parameter model
F81 (Felsenstein 1981) model


Pictures...pictures...pictures

My beautiful beautiful boy Ilay

Adam and Adi's marriage ceremony Top of the world (almost): Nepal 2004
Chupa's homepage

Things that I am crazy about

Music!

Level 1 - Nirvana (It's better to burn out than fade away. Kurt Cobain), Therapy, Dream Theatre, Rachmaninoff (Piano Concerto No. 2), Radiohead
Level 2 (non-exhaustive list) - Spock's Beard, Alice in Chains, Porcupine Tree, Guns 'n' Roses, Stone Temple Pilots, Knessiyat Ha-Sekhel, Algir

Fantasy / Sci-Fi / Other Silliness

One Ring to rule them all, One Ring to find them,
One Ring to bring them all and in the darkness bind them
In the Land of Mordor where the Shadows lie.

Don't panic! 42

We are the Knights who say..... "Ni"!