Eyal Privman       

I have moved!
I am now a postdoc in the University of Lausanne

Before, I did my Ph.D.
in the laboratory of Prof. Tal Pupko,
at the Department of Cell Research and Immunology,
George S. Wise Faculty of Life Sciences,
Tel Aviv University, Tel Aviv 69978, Israel,



Research interests in molecular evolution:

    Bioinformatics methodology:

  • Likelihood-based methods for phylogenetic tree reconstruction, involving evolutionary rate estimation, evolutionary distance estimation and distance-based methods for tree reconstruction.

  • The importance of the guide tree in progressive multiple sequence alignment, and the estimation of alignment sensitivity to errors in the guide tree.
    Applied biological research:

  • Co-evolution of homing endonucleases with their host genes, and its implications for the discovery and use of homing endonucleases in gene targeting (especially for gene therapy).

  • Co-evolution of viral and host genes, especially in herpesviridae and lentiviridae. Specifically, the co-evolution of antisense regulatory RNA with their targets and the co-evolution of viral proteins with host inate immunity factors.

  • Bacterial phylogeny reconstruction.

Publications and links to published software and resources

Privman, E.*, Penn, O.*, Pupko, T. 2011. Improving the performance of positive selection inference by filtering unreliable alignment regions. MBE doi: 10.1093/molbev/msr177.

Privman, E. 2010. Ph.D. Thesis: Hybrid methods inspired by the mutual dependency of sequence alignment and phylogeny reconstruction. Tel Aviv University, Faculty of Life Sciences.

Barzel, A.* Privman, E.*, Peeri., M., Naor, A., Shachar, E., Burstein, D., Lazary, R., Gophna, U., Pupko, T., and Kupiec, M. 2011. Native homing endonucleases can target conserved genes in humans and in animal models. NAR
      The HomeBase web server: a searchable collection of homing endonucleases for gene targeting

Penn, O.* Privman, E.*, Ashkenazy, H., Landan, G., Graur, D., and Pupko, T. 2010. GUIDANCE: a web server for assessing alignment confidence scores. NAR 38: W23-W28.
      The GUIDANCE web server: estimation of confidence scores for individual alignment positions

Penn, O.* Privman, E.*, Landan, G., Graur, D., and Pupko, T. 2010. An alignment confidence score capturing robustness to guide-tree uncertainty. MBE 27: 1759-1767.

Ninio, M.*, Privman, E.*, Pupko, T., and Friedman, N. 2007. Phylogeny reconstruction: increasing the accuracy of pairwise distance estimation using Bayesian inference of evolutionary rates. Bioinformatics 23: e136-e141
      Available as part of the SEMPHY package

Stern, A., Privman, E., Rasis, M., Lavi, S., Pupko, T. 2007. Evolution of the metazoan protein phosphatase 2C superfamily. JME 64: 61-70

*These authors contributed equally

Teaching:
Alignment workshop 2010 (presentation, materials)
Phylogeny workshop 2009 (materials)
Biological Sequences Analysis, The Academic College of Tel Aviv Yafo (1st semester 2009-2010)
Perl programming for biology (2nd semester 2008-2009, ")
Perl programming for biology (1st semester 2007-2008, ")
Perl programming for biology (1st semester 2006-2007)
Perl programming for biology (1st semester 2005-2006)

Collaborators:
Dan Graur and Giddy Landan (University of Houston), Martin Kupiec and Adi Barzel (Microbiology Dept.), Eithan Galun (Hadassah, Jerusalem), Nir Friedman and Matan Ninio (Givat Ram, Jerusalem), and my lab mates: Itay Mayrose, Adi Doron, Adi Stern, Ofir Cohen, Nimrod Rubinstein, Osnat Penn, David Burstein, Haim Ashkenazy, Tal Peled, Dayana Alaluf, David Zeevi
, and Yaara Oren

I am a fellow of the Edmond J. Safra Bioinformatics Program