The Felsenstein Medical Research Center
Immunology

Laboratory of Cellular and Vascular Immunology

Head of Laboratory: Prof. Britta Hardy, Ph.D.

Head of Research Group:Annat Raiter Ph.D.

  Tel/Fax: 972-3-9376782
Cell: 972-7527482
E-mail: bhardy@post.tau.ac.il

Research Topics

  1. Novel GRP78 targeting peptides for the treatment of ischemic diseases.
    1. Novel peptide binding cell surface endothelial cell induction of angiogenesis.
    2. Novel peptide binding GRP78 for prevention of hypoxia induced apoptosis in cardiomyocytes.
    3. Novel GRP78 binding peptides for Inhibition of apoptosis in neuronal cells.
    4. The molecular mechanism and signal transduction induced by novel GRP78 binding Peptides.
  2. The significance of cell surface GRP78 on tumor cells
    1. Stress protein GRP78 expression in colorectal cancer; Metastatic potential of colorectal tumor cells expressing cell surface heat shock protein GRP78.
    2. Clinical study on GRP78 in colorectal cancer patients
    3. Breast cancer receptors in correlation to cell surface GRP78 expression
    4. Clinical study on GRP78 in breast cancer patients
    5. Drug induced GRP78 expression.
    6. GRP78 expression on cells from human parotid glands; normal and malignant

Selected Publications:

  1. Raiter A, Bechor Z, Kleiman M, Leshem-Lev D, Battler A, Hardy B, Angiogenic peptides improve blood flow and promote capillary growth in a diabetic and ischemic mouse model. Euro. J. Vasc. & Endovasc. Surg, 40: 381-388, 2010 MEDLINE
  2. Hardy B, Raiter A. Peptide binding heat shock protein GRP78 protects cardiomyocytes from hypoxia induced apoptosis J. Mol. Med. 88: 1157-1167, 2010. MEDLINE
  3. Glaser-Gabay L, Raiter, A. Battler A, Hardy B. Endothelial cell surface vimentin binding peptide induces angiogenesis under hypoxic/ischemic conditions. Microvascular Research 82(3):221-6. 201.1 MEDLINE
  4. Goldenberg-Cohen N, Raiter A, Gaydar V, Dratviman-Storobinsky O, Goldstein T, Weizman A, Hardy B .Peptide-binding heat shock protein GRP78 protects neurons from hypoxia-induced apoptosis. Apoptosis. 17 (3) 278-288, 2012. MEDLINE
  5. Hardy B, Raiter A, Yakimov M, Wilkin A, Niv Y. Colon cancer cells expressing cell surface GRP78 as a marker for reduced tumorigenicity. Cellular Oncology 35(5):345-54, 2012. MEDLINE