The Laboratory of Diabetes and Obesity Research

Head of Laboratory: Pnina Vardi, MD

Head of Research Group:Konstantin Bloch Ph.D.

	Tel:	972-3-9376280/6631
	Fax:	972-3-9211478
	E-mail:	pvardi@post.tau.ac.il

Research Topics

1. Characterization of mixed T1DM/T2DM diabetic and pre-diabetic subjects by clinical, hormonal, immunological and genetic background in families with multiplex type 1 and type 2 diabetes

2. Prediction and prevention of metabolic syndrome and type 2 diabetes in children and adolescents Islet transplantation and tissue engineering of bio-artificial pancreas

3. The effect of hypoxia on pancreatic islet cell integrity and function

Selected Publications:

1. Bloch K, Bloch O, Tarasenko I, Lazard D, Rapoport M, Vardi P. A strategy for the engineering of insulin producing cells with a broad spectrum of defense properties. Biomaterials 32 : 1816-1825, 2011. MEDLINE

2. Bloch K, Vennäng J, Lazard D, Vardi P. Different susceptibility of rat pancreatic alpha and beta cells to hypoxia Histochem Cell Biol. 137(6):801-10, 2012 . MEDLINE

3. Lazard D, Vardi P, Bloch K. Induction of beta-cell resistance to hypoxia and technologies for oxygen delivery to transplanted pancreatic islets. Diabetes Metab Res Rev. 2012. doi: 10.1002/dmrr.2294. 28(6):475-84, 2012. MEDLINE

4. Ludwig B, Rotem A, Schmid J, Weir GC, Colton CK, Brendel MD, Neufeld T, Block NL, Yavriyants K, Steffen A, Ludwig S, Chavakis T, Reichel A, Azarov D, Zimermann B, Maimon S, Balyura M, Rozenshtein T, Shabtay N, Vardi P, Bloch K, de Vos P, Schally AV, Bornstein SR, Barkai U. Improvement of islet function in a bioartificial pancreas by enhanced oxygen supply and growth hormone releasing hormone agonist. Proc Natl Acad Sci U S A.;109(13):5022-7,2012. MEDLINE

5. Bloch K, Vanichkin A, Vardi P. Islet transplantation in a subarachnoid cavity surrounding olfactory bulb of diabetic rats. Transplantation, 95(8): 2013 (in press)