The Hagit Eldar-Finkelman Lab

Department of Human Molecular Genetics and Biochemistry

Research Fields

Laboratory Publications List

  1. Monte FL, Kramer T, Bol?nder A, Plotkin B, Eldar-Finkelman H, Fuertes A, Dominguez J, Schmidt B. Synthesis and biological evaluation of glycogen synthase kinase 3 (GSK-3) inhibitors: an fast and atom efficient access to 1-aryl-3-benzylureas. 2011. Bioorg Med Chem Lett. [PDF].
  2. Alon LT, Pietrokovski S, Barkan S, Avrahami L, Kaidanovich-Beilin O, Woodgett JR, Barnea A, Eldar-Finkelman H. Selective loss of glycogen synthase kinase-3alpha in birds reveals distinct roles for GSK-3 isozymes in tau phosphorylation. 2011. FEBS Lett. [PDF].
  3. Licht-Murava A, Plotkin B, Eisenstein M, Eldar-Finkelman H. Elucidating Substrate and Inhibitor Binding Sites on the Surface of GSK-3β and the Refinement of a Competitive Inhibitor. 2011. J Mol Biol. [PDF].
  4. Azoulay-Alfaguter I, Yaffe Y, Licht-Murava A, Urbanska M, Jaworski J, Pietrokovski S, Hirschberg K, Eldar-Finkelman H. Distinct molecular regulation of GSK-3alpha isozyme controlled by its N-terminal region. Functional role in calcium/calpain signaling. 2011. J. Biol. Chem. [PDF].
  5. Karyo R, Askira Y, Pinhasov A, Belmaker H, Agam G, Eldar-Finkelman H. Identification of eukaryotic elongation factor-2 as a novel cellular target of lithium and glycogen synthase kinase-3. 2010, Mol Cell Neurosci. [PDF].
  6. Eldar-Finkelman, H., Licht-Murava A, Pietrokovski S, Eisenstein M. Substrate Competitive GSK-3 Inhibitors- Strategy and Implications. 2009, Biochim. Biophys. Acta. [PDF].
  7. Shruster A, Eldar-Finkelman H, Melamed E, Offen D. Wnt signaling pathway overcomes the disruption of neuronal differentiation of neural progenitor cells induced by oligomeric amyloid beta-peptide. J Neurochem. 2011 Feb;116(4):522-9. doi: 10.1111/j.1471-4159.2010.07131.x. Epub 2011 Jan 24. [PDF].
  8. Leng S, Zhang W, Zheng Y, Liberman Z, Rhodes CJ, Eldar-Finkelman H, Sun XJ. Glycogen synthase kinase 3 beta mediates high glucose-induced ubiquitination and proteasome degradation of insulin receptor substrate 1. J Endocrinol. 2010 Aug;206(2):171-81. Epub 2010 May 13. [PDF].
  9. Watson RL, Spalding AC, Zielske SP, Morgan M, Kim AC, Bommer GT, Eldar-Finkelman H, Giordano T, Fearon ER, Hammer GD, Lawrence TS, Ben-Josef E. GSK3beta and beta-catenin modulate radiation cytotoxicity in pancreatic cancer. Neoplasia. 2010 May;12(5):357-65. [PDF].
  10. Eldar-Finkelman, H., Eisenstein, M. Peptides Inhibitors Targeting Protein Kinases. 2009, Current Pharmaceutical Design. 15(21):2463-70. [PDF].
  11. Ilouz, R, Pietrokovsky, S, Eisenstein, M, Eldar-Finkelman, H. 2008, New Insights into the Autoinhibition Mechanism of Glycogen Synthase Kinase-3β. J. Mol. Biol. 385:999-1007. [PDF].
  12. Liberman Z. Plotkin, B. Eldar-Finkelman, H., 2008, Coordinated Phosphorylation of Insulin receptor Substrate-1 by Glycogen Synthase Kinase-3 and Protein Kinase C3βII at in the Diabetic fat Tissue. 2008, Am. J. Physiol. Endocrinol. Metab. 294:E1169-1177. [PDF]
  13. Caspi, M., Zilberberg , A. Eldar-Finkelman, H., Rosin-Arbesfeld, R. Nuclear GSK-3beta inhibits the canonical Wnt signalling pathway in a beta-catenin phosphorylation-independent manner. 2008, Oncogene. 27:3546-3555. [PDF]
  14. Sharfi, H. Eldar-Finkelmnan, H. 2007, Sequential Phosphorylation of Insulin Receptor Substrate-2 by Glycogen Synthase Kinase-3 and c-Jun N-Terminal Kinase Plays a Role in Hepatic Insulin Signaling Am. J. Physiol. Endocrinol. Metab. 2008, 294: E307-15. [PDF]
  15. Erez A, Castiel A, Trakhtenbrot L, Perelman M, Rosenthal E,Goldstein I, Stettner N, Harmelin A, Eldar-Finkelman H, Campaner S, Kirsch I, Izraeli S. 2007, The SIL Gene Is Essential for Mitotic Entry and Survival of Cancer Cells. Cancer Res. 67:4022-4027. [PDF]
  16. Shapira, M. Licht, A. Milman, A. Pick,C.G., Shohami, E. Eldar-Finkelman, H. 2007. Role of Glycogen Synthase Kinase-3β in Early Depressive Behavior Induced by Mild Traumatic Brain Injury. Mol. Cell. Neuroscience. 34:571-577. [PDF]
  17. Ilouz, R., Kowalsman, N., Eisenstein, M., Eldar-Finkelman, H. 2006 Identification of Novel Glycogen Synthase Kinase-3β Substrate Interacting Residues Suggests A Common Mechanism For Substrates Recognition. J. Biol. Chem. 281:30621-30. [PDF]
  18. Kaidanovich-Beilin, O., Eldar-Finkelman, H. 2006, Peptides Targeting Protein Kinases-Strategies and Implicatiosn. Physiology, 21:411-8. [PDF]
  19. Kaidanovich-Beilin, O. and Eldar-Finkelman, H. 2006 Long-Term Treatment with Novel Glycogen Synthase Kinase-3 Inhibitor Improves Glucose Homeostasis in Ob/Ob Mice: Molecular Characterization In Liver And Muscle. J. Pharmacol. Exp. Ther. 316:17-24. [PDF]
  20. Liberman Z. and Eldar-Finkelman H. 2005, Serine332 Phosphorylation of Insulin Receptor Substrate-1 by Glycogen Synthase Kinase-3 Attenuates Insulin Signaling. J. Biol. Chem. 280:4422-8. [PDF]
  21. Tailor, I. Tennenbaum , T., Kuroki, T. Eldar-Finkelman, H. 2005, Protein Kinase C-δ Dependent Activation of Oxidative Stress In Adipocytes of Insulin Resistant and Obese Mice: role for NADPH oxidase. Am. J. Physiol. Endocrinol. Metab. 288:E405-11. [PDF]
  22. Kirshennboim, N., Plotkin, B., Ben Shlomo, S., Kaidanovich-Beilin, O., Eldar-Finkelman, H. 2004, Lithium-mediated phosphorylation of glycogen synthase kinase-3 involves PI3 Kinase-dependent activation of protein kinase C-α. J. Mol. Neuroscience, 24, 199-207. [PDF]
  23. Kaidanovich-Beilin, O., Milman, A., Pick, C., Weizman, A., Eldar-Finkelman, H. 2004, Rapid anti-depressive like activity of specific GSK-3 inhibitor, and its effect on β-catenin in the mouse hippocampus. Biol. Psychiatry, 55:781-784. [PDF]
  24. Eldar-Finkelman, H. Ilouz, R. 2003, Challenges and opportunities with glycogen synthase kinase-3 inhibitors in treatment of insulin resistance and type 2 diabetes, Expert Opin. Invs. Drug, 2003, 12 1511-1519. [PDF]
  25. Talior, I., Yarkoni, M., Bashan, N., Eldar-Finkelman, H. 2003, Increased Glucose Uptake Promotes Oxidative Stress and Activation of Protein Kinase C-δ in Adipocytes of Obese and Insulin-Resistant C57Bl/6J Mice. Am. J. Physiol. Endocrin. Metab. 285:E295-E302. [PDF]
  26. Plotkin B., Kaidanovich, O., Talior, I. Eldar-Finkelman, H. 2003 Insulin mimetic action of synthetic phosphorylated peptide inhibitors of glycogen synthase kinase-3. J. Pharmacol. Exp. Ther. Section- molecular and cellular. 305:974-980 [PDF]
  27. Kaidanovich-Beilin, O., Eldar-Finkelman, H. 2002, The role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetes. Expert. Opin. Ther. Targ.; 6:555-561. [PDF]
  28. Ilouz, R., Kaidanovich, O., Gurwitz, D., Eldar-Finkelman, H. 2002 Inhibition of glycogen synthase kinase-3β by bivalent zinc ions: insights into the insulin-mimetic action of zinc. Biochem. Biophys. Res. Commun. 295:102-106. [PDF]
  29. Gurwitz, D. Eldar-Finkelman, H. 2002, GSK-3 inhibitors: potential drugs for neurodegenerative disorders. Drug Discovery Today; 6: 1072-1074. [PDF]
  30. Eldar-Finkelman, H. 2002, Glycogen synthase kinase-3: an emerging therapeutic target. Trends Mol. Med; 8:126-132. [PDF]
  31. Hall, J.L., Chatham, J.C., Eldar-Finkelman H., Gibbons, H. 2001 Upregulation of glucose metabolism during intimal lesion formation is coupled to the inhibition of vascular smooth muscle cell apoptosis: role of GSK-3β. Diabetes; 50:1171-9 [PDF]
  32. Zhao, A.Z., Shinohara, M.M., Huang, D., Shimizu, M., Eldar-Finkelman, H. Krebs, E.G., Beavo, J.V., Bornfeldt, K.E. 2000, Leptin induces insulin-like signaling that antagonizes cAMP elevation by glucagon in hepatocytes. J. Biol. Chem.; 275:11348-54. [PDF]

    33. Hagit Eldar-Finkelman Publications List

  33. Eldar-Finkelman H. Schreyer, S.A., M.M. Shinohara, M.M., Leboeuf, R.C., Krebs, E.G.1999, Increased glycogen synthase kinase-3 activity in diabetes and obesity prone C57BL/6J mice Diabetes; 48:1662-1666.
  34. Torres M., Eldar-Finkelman, H. Krebs, E.G. Moon, R.T. 1999, Regulation of S6 ribosomal protein kinase p90 RSK, glycogen synthase kinase-3 and β-catenin in Early Xenopus Development. Mol. Cell Biol; 19:1427-37.
  35. Eldar-Finkelman H., Krebs E.G. 1997, Phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 impairs insulin action. Proc. Natl. Acad. Sci. USA; 94:9660-64.
  36. Eldar-Finkelman, H., Agrast G.M., Foord O., Fischer E.H. Krebs E.G. 1996, Expression and characterization of glycogen synthase kinase-3 mutants and their effect on glycogen synthase activity. Proc. Natl. Acad. Sci. USA; 93:10228-33.
  37. Eldar-Finkelman H., Seger, R., Vandenheede, J .R., Krebs, E.G. 1995, inactivation of glycogen synthase kinase-3 by epidermal growth factor is mediated by mitogen-activated protein kinase/p90 ribosomal protein S6 kinase signaling pathway in NIH/3T3 cells. J. Biol. Chem.; 270:987-90.
  38. Slack, B.E., Breu, J., Livneh E., Eldar, H., Wurtman, R.J. 1995, Phorbol esters stimulate choline uptake in Swiss 3T3 fibroblasts following introduction of the gene encoding protein kinase C α. Biochem. .J.; 305: 621-6.
  39. Seger, R., Seger, D., Reszka, A.A., Munar, E.S., Eldar-Finkelman, H., Dobrowolska, G., Jensen, A.M., Campbell, J.S., Fischer E.H., Krebs, E.G. 1994, Overexpression of mitogen-activated protein kinase kinase (MAPKK) and its mutants in NIH 3T3 cells. Evidence that MAPKK involvement in cellular proliferation is regulated by phosphorylation of serine residues in its kinase subdomains VII and VIII. J. Biol. Chem.; 269:25699-709.
  40. Fitzer-Attas, C., Eldar, H., Eisenbach, L., Livneh, E. 1994, Expression of PDGF-α but not PDGF-β receptor is regulated in protein kinase C-α overexpressing Swiss/3T3 fibroblasts. FEBS-Letters; 342:165-70.
  41. Slack, B.E., Nitsch, R.M., Livneh, E., Kunz, G.M. Jr, Eldar, H., Wurtman, R.J. 1993 Regulation of amyloid precursor protein release by protein kinase C in Swiss 3T3 fibroblasts. Ann N Y Acad Sci; 695:128-31.
  42. Eldar, H., Ben-Av, P., Schmidt, U.S., Livneh, E., Liscovitch, M. 1993, Up-regulation of phospholipase D activity induced by overexpression of protein kinase C-α Studies in intact Swiss/3T3 cells and in detergent-solubilized membranes in vitro J. Biol. Chem.; 268:12560-64.
  43. Liscovitch, M., Ben-Av, P., Danin, M., Faiman, G., Eldar, H., Livneh, E. 1993, Phospholipase D-mediated hydrolysis of phosphatidylcholine: Role in cell signaling. J. Lipid Mediators; 8:177-82.
  44. Slack, B.E., Nitsch, R.M., Livneh, E. Kunz, G.M., Breu, J., Eldar, H., Wurtman, R.J. 1992, Regulation by phorbol esters of amyloid precursor protein release from Swiss/3T3 fibroblasts overexpressing protein kinase C-α. J. Biol. Chem.; 268:21097-101.
  45. Eldar, H., Livneh, E. 1992, Phosphorylation of p90 and p52 accompanies the response to phorbol esters in Swiss/3T3 cells overexpressing protein kinase C-α. Mol. Biol. Cell.; 3:1049-56.
  46. Eldar, H,. Ben-Chaim, J., Livne, E. 1992, Deletions in the regulatory or kinase domains of protein kinase C-α causes association with the cell nucleus. Exp. Cell. Res.; 202: 259-66.
  47. Greif, H., Ben-Chaim, J., Shimon, T., Bechor, E., Eldar, H., Livneh, E. 1992, The protein kinase C-related PKC-L(eta) gene product is localized in the cell nucleus. Mol. Cell. Biol.; 123:1304-11.
  48. Raber, J., Eldar, H., Lehrer, R., Chabath, J., Livneh, E. 1991, Regulation of the interferon-induced 100kda 2'-5' A synthetase by A23187 and Protein Kinase C. Eur. Cytokine Net.; 2: 281-90.
  49. Eldar-Finkelman, H., Zisman, Y., Ullrich, A., and Livneh, E. 1990. Overexpression of protein kinase C-α in Swiss/3T3 cells reduces the number of both high and low affinity of the epidermal growth factor Signal Transduction, Vol. 51, p. 271-81: Springer-Verlag press.
  50. Eldar, H., Zisman, Y., Ullrich, A., Livneh, E. 1990, Overexpression of protein kinase C-α subtype in Swiss/3T3 fibroblasts causes loss of both high and low affinity receptors for epidermal growth factor. J. Biol. Chem.; 265:13290-296.
  51. Seymour, A.M., Eldar, H., Radda, G.K. 1990, Hyperthyrodism results in increased glycolytic capacity in the rat heart. 31P NMR studies. Biochem. et Biophys. Acta.;1055:107-16.
  52. Neeman, M., Eldar, H., Rushkin, E., Degani, H.1990, Chemotherapy-induced changes in the energetics of human breast cancer cells, 31P and 13C NMR studies. Biochem. et. Biophys. Acta.; 1052:55-63.
  53. Eldar, H., Degani, H. 1989, 31P NMR studies of the thermodynamics and kinetics of the creatine kinase reaction. J. Magn. Reson. Med.; 11:12126.
  54. Saper, M.A., Eldar, H., Nickole, J., Appela, E. Sussman, J.L. 1986, Crystalization of a DNA tridecamer. J. Mol. Biol.; 188:111-3.

    55. Chapters in books

  55. Eldar-Finkelman, H., Yarkoni, M. 2002, “Insulin resistance and glycogen synthesis, roles in liver muscle and adipose tissue”. Insulin Resistance and Insulin Resistance Syndrom edited by B. Hansen and E. Shafrir, in Frontiers in Animal Diabetes Research, 3-21. Series Editors A.F. Sima and E. Shafrir, Harwood academic press.

    56. Editor

  56. Eldar-Finkelman, H. Editor of special Issue theme - Glycogen Synthase Kinase-3 in Health and Disease, Current Drug Targets, 2006, 7:1375.

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