Sunday, May 9th

From 14:00           Check in at Berliner Ring Hotel

19:30-20:00           Get together cocktail

20:00-21:30           Dinner

 

Monday Morning, May 10

08:45-09:00          Welcome: Prof. Dr. Cornelius Frömmel,

                           Vice Dean of Research, Charité Berlin, Germany

REASONING ABOUT STEADINESS AND VARIABILITY IN COMPLEX SYSTEMS

                                       

                           Chair: Wolfgang Dubiel

 

09:00        A1       Kay Hofmann, Memorec, Germany

                            Proteasome and CSN structure and function - A genomic Perspective

 

09:30        A2       Dieter Wolf, Harvard School of Public Health, USA

PCI Proteins Int6p/eIF3e and Csn7Bp/eIF3l Define Distinct Translation Initiation Factor 3 Complexes in Fission Yeast

 

10:00        A3       Wolfgang Dubiel, Charité Berlin, Germany

The COP9 signalosome interacts with the proteasome

 

10:30-11:00                               Coffee

 

10:50        A4       Eric C. Chang, Baylor, College of Medicine, USA

Int-6 - A PCI protein that regulates Tumorigenesis And the Proteasome

 

11:20        A5       Albrecht G. von Arnim, Univ. of Tennessee, USA

                           Translational role of the h subunit of eIF3 & its interaction with the COP9 signalosome

 

11:35                    End of Session

 

12:00-13:00                               Lunch

 

 

Monday Afternoon, May 10

                           Chair: Michael Naumann

 

14:00        B1       Yosef Shiloh, Tel Aviv University, Israel

   FUNCTIONAL LINK BETWEEN ATM AND THE COP9 SIGNALOSOME IN THE DNA DAMAGE RESPONSE    

 

14:30        B2       Juergen Bernhagen, RWTH Aachen, Germany

   Differential role for CSN5/JAB1 in intra- and extracellular action of macrophage migration inhibi­tory factor (MIF)

 

15:00        B3       Michael Naumann, Univ. of Magdeburg, Germany

                           COP9 SIGNALOSOME AND DYNAMIC INTERACTIONS IN NF-κB REGULATION

 

15:30-15:50                               Coffee

 

15:50        B4        Melanie Füllbeck, Charité Berlin, Germany

                            IN SILICO SCREENING FOR SIGNALOSOME INHIBITORS

 

16:05        B5       Silke Busch, University Göttingen, Germany

THE COP9 SIGNALOSOME IS AN ESSENTIAL REGULATOR OF DEVELOPMENT IN THE FILAMENTOUS FUNGUS ASPERGILLUS NIDULANS

 

16:20        B6        Esther M.N. Dohmann, Univ. Tübingen, Germany

                            investigations into csn5 function in arabidopsis

 

16:35        B7       Giovanna Serino, La Sapienza Univ., Rome, Italy

Uncovering cop9 signalosome-dependent processes in plants through the isolation of new csn interacting proteins

 

16:50        B8        Johannes A. Schmid, University of Vienna, Austria

                            COP9 IS A REGULATOR OF NF-kB ACTIVATION

                

17:05        B9        Orit Harari-Steinberg, University Tel Aviv, Israel

 csn5 regulates immune response in drosophila melanogaster

 

17:20                    End of Session

 

 

Monday Evening, May 10

 

 

                           Chair: Peter M. Kloetzel

 

18:20        C1       Claus Scheidereit, MDC Berlin, Germany

Homeostatic and inductive control of NF-kB/IKK pathways by ubiquitination and proteolysis at the co- and posttranslational levels

 

19:00                    End of Session

 

19:30-21:00                                 Dinner

 

 

 

Tuesday Morning, May 11

 

                           Chair: Ning Wei

 

09:00        D1       Elizabeth Strickland, Xing Wang Deng, Yale University, USA           

                           THE COP9 SIGNALOSOME AND ITS ROLE IN PLANT DEVELOPMENT

 

09:30        D2       Claus Schwechheimer, ZMBP Tübingen, Germany

   THE ROLE OF CSN AND CSN5 IN AUXIN RESPONSE IN ARABIDOPSIS THALIANA

 

10:00        D3       Ning Wei, Yale University, USA

DISRUPTION OF CSN2 IN MOUSE CAUSES DEFICIENT CELL PROLIFERATION, ACCUMULATION OF p53 AND CYCLIN E, AND EARLY EMBRYONIC DEATH

 

10:30-10:50                                 Coffee

 

10:50        D4       Harry A. Drabkin, University of Colorado, USA

   GROWTH SUPPRESSION INDUCED BY THE t(3;8) HEREDITARY RENAL CANCER TRC8 GENE IS DEPENDENT UPON JAB1/CSN5

 

11:20        D5      Susan Wee, Harvard School of Public Health, USA

                          THE ROLE OF CSN AND UBP12P IN SCF E3 LIGASE ASSEMBLY

 

11:35        D6       Junetai Wu, Academia Sinica, Taiwan

   Regulation of the SCF complex by the COP9 signalosome and the 26S proteasome

 

11:50                   End of Session

 

12:00-13:00                                 Lunch

 

 

Tuesday Afternoon, May 11

 

                          Chair: Daniel Chamovitz

 

14:00        E1       Antony M. Carr, University of Sussex, UK

   Control of RNR by the Signalosome (CSN) and DNA structure checkpoints pathways

 

14:30        E2       Jun-ya Kato, NAIST, Japan

Jab1 is essential for early embryonic development and growth potentials in mice

 

15:00        E3       Daniel Chamovitz, Tel Aviv University, Israel

THE COP9 SIGNALOSOME IN DROSOPHILA: CAN WE MAKE SENsE OUT OF PLEIOTROPY?

 

15:30-15:50                               Coffee

 

15.50        E4       Pierre Jalinot, CNRS/ENSL, Lyon, France

ANALYSIS OF THE FUNCTION OF HUMAN INT-6 BY RNA INTERFERENCE

 

16:20        E5       Hui Zhang, Yale University, USA

   REGULATION OF CHROMATIN POLYPLOIDY AND DNA DAMAGE CHECKPOINT BY CSN AND CULLIN UBIQUITIN E3 LIGASE COMPLEXES

 

16:35        E6       Gustavo J. Gutierrez, EMBL Heidelberg, Germany

   Regulation of the Cdk-activating protein RINGO by the ubiquitin-proteasome system controls meiotic progression in Xenopus oocytes

 

16:50        E7       Dina Raveh, Ben Gurion Univ. of the Negev, Israel

   ROLE OF THE UBL-UBA PROTEIN DDI1 IN DEGRADATION OF HO ENDONUCLEASE OF YEAST

 

17:05                    End of Session

 

17:30                    Departure: Berlin Sightseeing Tour & Dinner (optional)

 

 

 

Wednesday Morning, May 12

 

                          Chair: Michael Glickman

 

08:00        F1       Peter M. Kloetzel, Charité Berlin, Germany

   Antigen presentation revisited: A central role for 20S proteasomes in MHC class I antigen processing?

 

08:30        F2       Yosef Shaul, Weizmann Institute of Science, Israel

   Regulated protein degradation by the 20S proteasomes

                  

09:00        F3       Carlos Gorbea, University of Utah, USA

   DOES MAMMALIAN Ecm29 COUPLE THE 26S PROTEASOME TO ENDOCYTIC AND SECRETORY COMPARTMENTS?

                             

09:30        F4       Rati Verma, Caltech, USA

   MULTIUBIQUITIN CHAIN BINDING PROTEINS FUNCTION AS SUBSTRATE-SELECTIVE RECEPTORS IN THE UPS              

 

10:00-10:20                               Coffee

            

10:20        F5       Colin Gordon, MRC Edinburgh, Scotland

TRANSFERRING SUBSTRATES TO THE 26S PROTEASOME IN THE FISSION YEAST SCHIZOSACCHAROMYCES POMBE.

 

10:50        F6       Huong Jade Thien Thi Tran, MRC Cambridge, UK

   Structure of the Jab1/MPN domain and its implications for proteasome function

 

11:20        F7       Michael Glickman, Technion, Haifa, Israel

   THE PROTEASOME AND THE DELICATE BALANCE BETWEEN DEUBIQUITINATION AND PROTEOLYSIS

 

11:45                   End of Session

11:45-11:50          Closing Remarks

 

12:00-12:45                               Lunch

 

12:45                    Departure

 

Remark:  The program is subject to changes