RESEARCH  ACTIVITIES

Most of the appointed faculty members conduct their research in the Hospitals affiliated to the Faculty. Moreover some projects are performed in collaboration with researchers of the School of Medicine.

Once a year the Department participates in a 2 days Congress hold in the Building of the Sackler School of Medicine. During this event we are proud to present the product of the research performed in the Hospitals affiliated to the Faculty.

1. Parkinson's disease:
1. The effect of selegiline and levodopa on the homeostasis of blood presssure and plasma norepinphrine levels (HPLC) during orthostatic test in Parkinsonian patients.
2. Seroronin uptake by vesicular granules in platelets of Parkinsonian patients with and without depression and controls measured with labeled tetrabenazine (H3 TBZ).
3. The effect of cholinesterase inhibitors on cognitive functions and P300 potentials in Parkinsonian patients with dementia.
4. The clinical effect of Rasagiline, a new MAO B inhibitor compared to Entacapone and placebo (double blind multicenter study) in Parkinsonian patients.
5. The effect of ethyl ester Levodopa vs regular Levodopa in the motor performance of Parkinsonian patients (double blind multicenter study).
6. The effect of a new atypical antispychotic Quetiapine (Seroquel) in the LD induced psychosis in Parkinsonian patients (double blind study vs placebo).
7. The characteristics of H responses in lower limbs of Parkinsonian patients with and without medication versus controls and patients with spasticity (neurophysiological study).


2. Multiple sclerosis:
1. Cytokines in MS patients.
2. Cognitive performance and P300 potentials in MS patients receiving Betaferon.
3. The effect of Glatiramate acetate (Copaxone) daily versus each two days administration in MS.
4. Clinical characteristics of spinal MS.
5. Characterization of MS in aged patients.
6. Clinical effect of oral Copaxone in MS patients (double blind versus placebo multi-center study).


3. Stroke
1. The effect of Diamox in brain perfusion as measured with Trans-Cranial Doppler (TCD) in patients with Cerebrovascular diseases.
2. The benefit of Clopidogrel (Plavix) and aspirine versus aspirine alone as secondary prevention in patients with diabetes, myocardial infarction, or PVD and stroke (double blind multi-center study).


4. Dementia
1. The effect of cholinesterase inhibitors on the cognitive performances and P300 in Vascular and, Alzheimer’s dementia.
2. The effect of Donepezil on the cognitive performance of Schizophrenic patients with dementia (double blind study).


5. Sleep
1. Characterization of sleep structure in-patients with brain tumors.
2. Characterization of sleep structure in-patients with Parkinsonism and daily somnolence versus Parkinsonian patients without somnolence.
3. The influence of AEDS (antiepileptic drugs) on sleep structure and dreaming in epileptic patients.


6. Neurootology
1. Anxiety in-patients with acute vertigo.
2. Cochlear-spinal reflex: a new way to measure vestibular function (a neurophysiological study)
7. Clinical Neurology
1. Clinical characterization of West Nile meningo-encephalitis during the 2000-2001 outbreak.
2. Clinical admissions for headaches in the Neurological Ward.
3. A five years analysis.


8. Neurophysiology
1. The EEG in adult patient with West Nile encephalitis.
2. Post-ictal changes in P300 following a generalized tonic – clonic seizure.
3. The P300 intra – subject variability in healthy subjects.
4. Computerized EEG and P300 in Schizophrenic patients.
5. The effect of syncope on P300
6. P300 – guided cognitive function in PTSD patient.
7. Clinical features of children with FIRDA


Department of Neurology, The Chaim Shiba Medical Center


1. Neuroimmunology and Dementia
1. Neurological manifestations of systemic autoimmune diseases
2. Genetics of neuroimmunological diseases
3. Animal models of neuroimmunological diseases
4. Genetics of dementia
2. Epilepsy and Elecroencephalography
1. Genetics of epilepsy
2. Antiepileptic medications and male fertility
3. Antiepileptic medications and sweating mechanism
4. Quantitative EEG in psychiatric disease
3. Movement disorders
1. Genetics of Parkinson's disease
2. Gait analysis in movement disorders
3. Predictive factors for shunting in Normal Pressure Hydrocephalus
4. Botulinum toxin for drooling in neurological disorders
5. Spinocerebellar Ataxias in Israel
4. Neuromuscular Diseases & Electromyograph
1. Aging and Changes in the Motor System
2. Measuring Peripheral And Central Elements Of Motor Function
3. Therapeutic Uses of Botulinum toxin in Central and Peripheral Motor Disorders
5. Cerebrovascular disease/Stroke
1. Epidemiology of stroke & stroke prevention
2. Risk factors for stroke (Blood lipids, inflammatory markers, triggers, psychosocial factors, antiphospholipid syndrome and others)
4. Stroke and heart disease
5. Thrombolytic therapy for acute stroke
6. Cerebral blood flow and cerebral vasomotor reactivity


Department of Neurology, The Edith Wolfson Medical Center


1. Neuromuscular disorders (Menachem Sadeh MD)
2. Stroke and vascular disorders (Yair Lampl MD)
3. Disequilibrium and vertigo (Avraham Rapoport MD)
4. EEG and epilepsy (Ronit Gilad MD)
5. Neuropharmacology (Yechiel Eschel MD)
6. Neuromuscular disorders (Ron Dabby MD)


Department of Neurology, Rabin Medical Center- Beilinson Campus


1. Parkinson's Disease and other movement disorders - (Prof. Melamed, Dr. Djaldetti, Dr. Ziv)
2. Alzheimer's disease and other dementias- (Dr. Treves, Dr. Klimovitzky)
3. Dystonia- (Dr. Zoldan)
4. Migraine and other headaches (Dr. Kuritzky)
5. Multiple Sclerosis, myasthenia gravis, Neuroimmunology (Dr. Mosberg)
6. The dopaminergic system, neurodegeneration, neuronal apoptosis, neuroprotection, experimental models of human neurodegenerative disorders, molecular biology- (Dr. Offen)


Department of Neurology, Sapir Medical Center


1. Research outline:
1. Hereditary disorders in Jews
2. Periodic hypersomnia and Kleine-Levin syndrome
3. Autonomic dysfunction – a multidisciplinary approach
4. Event related potentials in epilepsy and learning disability
5. Vestibular functions in hereditary ataxias
6. Vestibular functions in mitochondrial myopathies
7. Vestibular function and anxiety
8. Benign Paroxysmal Positional Vertigo (BPPV)
9. Adaptive plasticity in the control of locomotion
10. Neurological rehabilitation in locomotor disorders
11. Ocular-motor tests in whiplash associated disorders
12. Ocular motor abnormalities in extrapyramidal disorders
13. Triptans in Migraine
14. The autonomic system in Migraine
15. Drug (analgesic) abuse and headaches
16. Psychological aspects of migraine
17. Epidemiology of ceroid lipofuscinosis in Israel


2. Topics for research cooperation:
   
   1. Pseudotumor cerebri in morbid obesity
   2. Functional MRI in dyslectic readers
   3. The prognosis of adult dyslexia
   4. Stimulant treatment of adult attention disorder
   5. HLA typing in Kleine-Levin syndrome
   6. Gait abnormalities and gait cueing
   7. Neurological rehabilitation of gait disorders
   8. Vestibular function in neurological disorders
   9. Ocular motor function in neurological disorders
   10. Sleep disorders
   11. Motion sickness


Department of Neurology, Tel Aviv Sourasky Medical Center


1. Stroke and other cerebrovascular diseases - (Prof. Bornstein, Dr. Gur, Dr. Bova, Dr. Aharonovitz).
2. Parkinson's Disease, other movement disorders and autonomic disorders –(Dr. Giladi, Dr. Gurevich, Dr. Shabtai, Dr. Balash)
3. Epilepsy, EEG and video-EEG monitoring (Prof. Neufeld, Dr. Chistick, Dr. Kipervasser)
4. Neuromuscular diseases, ALS, EMG (Dr. Drory, Dr. Groozman, Dr. Rabie).
5. Migraine, other headaches and facial pain (Dr. Mosek, Dr. Dano).
6. Multiple sclerosis, myasthenia gravis and other neuroimmunological disorders (Dr. Chilkevitz).
7. Alzheimer disease and other dementias (Prof. Korczyn, Dr. Mordechovitz, Dr. Verchovsky).