![]() |
![]() |
![]() |
![]() |
|
Associate Professor Affiliation: 1991-present (tenure:1996) Neufeld Cardiac Research Institute and Dept. of Physiology & Pharmacology Sackler School of Medicine Tel-Aviv University B.Sc. in Chemistry, cum laude, 1972 – Technion, Haifa. D.Sc. in Physiology and Biophysics, 1980, Faculty of Medicine, Technion, Haifa. Post-doctoral fellowship in Neurobiochemistry, Tel Aviv University, The George Wise Faculty of Life Science, Dept of Biochemistry (1983-1990) Visiting Scientist and Human Frontiers scholar, in Columbia University, Center for Neurobiology and Behavior, New York, USA. (2001) Signal transduction, Epigenetic mechanisms, PARP and polyADP-ribosylation; Molecular mechanisms underlying memory formation; PARP-1 activation in the ERK signaling cascade, Implication of PARP-1 activation in ERK-pending malignancy. Cohen-Armon M., FEBS Meeting 2008, Athens. PARP-1 activation mediates the expression of immediate early genes implicated in long-term memory formation FEBS J. 275 :92. Cohen-Armon M. 2007. PARP-1 activation in the ERK signaling pathway. Trend Pharmacol. Sci. 28: 556-560. Cohen-Armon M., Visochek L., Rozensal D., Kalal A., Klein R., Bendetz-Netzer S., Yao Z., and Seger R. 2007. DNA-independent PARP-1 activation by phosphorylated ERK2 increases Elk1 activity: A link to histone acetylation. Mol. Cell 25: 297-308. Bar-Shira Maymon B., Cohen-Armon M., Yavetz H., Yogev L., Lifschitz-Mercer, Kleiman S.E., Botchan A., and Paz G. 2006. Role of polyADP-ribosylation during human spermatogenesis. Fertil Steril. 86(5):1402-1407. Visochek L., Steingart R., Vulih R.A., Klein R., Priel E., Gozes I., and Cohen-Armon M. 2005. PolyADP-ribosylation is involved in neurotrophic activity J. Neurosci. 25:7420-7428. Editorial: PARP-1 activation and neurotrophins. 25: 1. Cohen-Armon M., Visochek L., Katzoff A., Levitan D., Susswein A.J. , Klein R.,Valbrun M., and Schwartz J.H. 2004. Long-term memory requires polyADP-ribosylation. Science 304: 1820-1823. Editorial: ‘DNA damage and Long-Term Memory‘, 1715. Dekel N., Visochek L., Anis Y. and Cohen-Armon M. 2003. Stimulation-induced modifications in Go-proteins examined in giant synaptoneurosomes. J. Mol. Neurosci. 20: 73-80. Homburg, S., Visochek, L., Moran, N., Dantzer, F., Priel, E., Asculai, E., Schwartz, D., Rotter, V., Dekel, N., and Cohen-Armon, M., 2000. A fast signal-induced activation of poly(ADP-ribose) polymerase : A novel downstream target of phospholipase C. J. Cell Biol. 150:293-307. Editorial ‘Depolarization activates PARP’ by William A. Wells. J. Cell Biol. 150(2):2. Chapman, J., Cohen-Armon, M., Shoenfeld, Y., and Korczyn, A. D. 1999. Anti-phospholipid antibodies permeabilize and depolarize brain synaptoneurosomes. LUPUS 8:127-133. Anis, Y., Nurnberg, B., Visochek L., Reiss, N., Naor, Z. and Cohen-Armon, M. 1999. Activation of Go-proteins by membrane depolarization traced by in-situ photoaffinity labeling of Gao-proteins with [a32P]GTP-azidoanilide. J. Biol. Chem. 274: 7431-7440. Cohen-Armon, M., Hammel, I., Anis, Y., Homburg, S. and Dekel, N. 1996. Evidence for endogenous ADP-ribosylation of GTP-binding proteins in neuronal cell nucleus: Possible induction by membrane depolarization. J. Biol. Chem. 271: 26200-26208 Maymon, R., Bar-Shira Maymon, B., Cohen-Armon, M., Holtzinger, M. and Leibovici, J. 1994. Enhancing effect of ATP on intracellular adriamycin penetration in human ovarian cancer cell line.Biochem. Biophys. Acta 1201: 173-178 Cohen-Armon M, Sokolovsky M 1993. Evidence for involvement of voltage-dependent Na-channel gating in depolarization-induced activation of G-proteins. J. Biol Chem. 268: 9824-9838 Cohen-Armon M, Sokolovsky M 1991. Depolarization-induced changes in the muscarinic receptor in rat brain and heart are mediated by pertussis-toxin-sensitive G-proteins. J. Biol. Chem. 266: 2595-2605 Cohen-Armon, M., Garty, H. and Sokolovsky, M. 1988. G-protein mediates voltage regulated interaction of muscarinic receptors with Na-channels. Biochemistry –US 27: 368-374. Sokolovsky, M., and Cohen-Armon, M. 1988. Cross-talk between receptors: Muscarinic receptors, sodium channel and guanine nucleotides binding proteins in rat membrane preparation and synaptoneurosomes. In: Advances in Second Messengers and Phosphoprotein Research, Vol. 21 (Adelstein, R., Klee, C. and Rodbell, M., eds.) Raven Press ltd. New York Cohen-Armon, M. and Sokolovsky, M. 1986. Interactions between the muscarinic receptors, sodium cannels and guanine nucleotide-binding protein(s) in rat atria. J. Biol. Chem. 261:12498-12505. Cohen-Armon M, Kloog Y, Henis YI, Sokolovsky M 1985. Batrachotoxin changes the properties of muscarinic receptor in rat brain and heart: Possible interaction between muscarinic receptor and sodium channel. Proc. Natl. Acad. Sci. USA 82: 3524-3527
| |||
